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Fig. 8 | Chinese Medicine

Fig. 8

From: Geniposide suppresses NLRP3 inflammasome-mediated pyroptosis via the AMPK signaling pathway to mitigate myocardial ischemia/reperfusion injury

Fig. 8

The underlying molecular mechanisms of the protective effects of geniposide against the myocardial ischemia/reperfusion injury of mice. Scheme summarizing the protective effects of GEN on MI/RI via activating of AMPK signaling and inhibiting of ROS/TXNIP/NLRP3 mediating inflammation and subsequent pyroptosis-related signaling pathways. Under physiological conditions, Trx binds to TXNIP in its reduced form and suppresses activity. However, MI/RI amplifies ROS overproduction, which results in Trx dissociating from TXNIP, and thereby TXNIP/NLRP3 activation. This process leads to inflammation and pyroptosis. Importantly, GEN upregulates the AMPK signaling pathway, contributing to inhibit MI/RI-induced oxidative stress and TXNIP/NLRP3 activation, which were effectively inhibition inflammation and subsequent pyroptosis

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