Fig. 5

RNAseq analysis reveals the molecular mechanism of AP-treated skin. a Volcano plot of the differentially expressed genes between AP and VC-treated groups (FC > 1, p < 0.01). b Highly enriched Gene ontology (GO) analysis of up-regulated genes in AP group. c GO Chord plot showing the expression spectrum of significantly upregulated gene in the Go terms. Genes are selected according to the log₂FC, and they are linked to their assigned term via colored ribbons. d Summary of histospecific gene enrichment analysis in PaGenBase. e Gene set enrichment analysis (GSEA) between AP and VC-treated groups. f Heat map of genes that are significantly up-regulated in epidermis development and Wnt signaling pathways, n = 4 mice per group