Fig. 5

Real-time PCR analysis for mRNA expression of RANKL, OPG, OCN, ALP, ColA, and ERβ in the tibia (A). The levels of osteoblastic and osteoclastic biomarkers in OVX rats’ tibia (B) and serum (C). Data are expressed as mean ± SD (n = 6). Data were presented as mean ± SD, n = 6. *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001 determined by two-way ANOVA test, followed by Tukey’s post hoc test