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Table 2 Serum metabolites of RA DP patients

From: Serum metabolomics analysis of deficiency pattern and excess pattern in patients with rheumatoid arthritis

No. Metabolite m/z RT (min) Formula VIP Fold Change Trend
1 L-Homocysteic acid 184.07 8.01 C4H9NO5S 3.93 − 2.25
2 5-Methoxytryptamine 191.04 0.57 C11H14N2O 1.43 − 2.54
3 4-Fumarylacetoacetic acid 182.96 0.48 C8H8O6 2.09 10.33
4 S-Nitrosoglutathione 337.06 0.62 C10H16N4O7S 10.09 2194.14
5 LysoPE(P-16:0/0:0) 438.30 8.35 C21H44NO6P 1.14 − 2.06
6 LysoPC(16:0/0:0) 496.34 8.16 C24H50NO7P 32.88 − 2.01
7 LysoPC(P-18:0/0:0) 508.38 8.55 C26H54NO6P 3.03 − 3.02
8 LysoPC(18:1(9Z)/0:0) 522.36 8.37 C26H52NO7P 14.21 − 2.14
9 LysoPC(20:1(11Z)/0:0) 550.39 8.87 C28H56NO7P 1.53 − 2.68
10 Bisdiphosphoinositol tetrakisphosphate 820.81 0.55 C6H20O30P8 1.27 2.87
11 PE(22:0/24:0) 888.80 0.55 C51H102NO8P 1.41 2.78
12 PC(24:0/24:1(15Z)) 956.79 0.55 C56H110NO8P 1.35 2.58
13 Pyruvic acid 174.96 0.49 C3H4O3 5.03 12.87
14 D-Ribose 130.97 0.49 C5H10O5 2.13 7.30
15 N(omega)-Hydroxyarginine 224.98 0.63 C6H14N4O3 1.42 − 7.41
16 Citric acid 191.02 0.64 C6H8O7 3.10 6.36
17 Gamma-Glutamylserine 269.08 0.60 C8H14N2O6 4.22 41.27
18 5-Thymidylic acid 357.03 0.63 C10H15N2O8P 4.62 2.49
19 Inosinic acid 329.04 0.59 C10H13N4O8P 6.12 112.81
20 SN38 glucuronide 549.05 0.64 C28H28N2O11 1.58 21.42
21 Glucosylceramide (d18:1/12:0) 678.51 0.56 C36H69NO8 1.07 − 3.46
22 PE(20:3(5Z,8Z,11Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z)) 794.42 0.56 C47H76NO8P 1.96 − 3.95
23 PC(O-22:1(13Z)/22:3(10Z,13Z,16Z)) 878.77 0.48 C52H98NO7P 1.78 4.00
24 PE(22:0/24:1(15Z)) 866.78 0.53 C51H100NO8P 1.90 3.09
25 Octanoyl-CoA 874.24 0.48 C29H50N7O17P3S 1.38 3.61
  1. Fold change refers to the “RA DP group vs. healthy group” change value
  2. LysoPE Lysophosphatidylethanolamine; LysoPC Lysophosphatidylcholine; PC Phosphatidylcholine; PE Phosphatidylethanolamine