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Table 3 Serum metabolites of RA EP patients

From: Serum metabolomics analysis of deficiency pattern and excess pattern in patients with rheumatoid arthritis

No. Metabolite m/z RT (min) Formula VIP Fold Change Trend
1 Gamma-Aminobutyric acid 104.11 8.16 C4H9NO2 2.56 -2.28
2  L-Homocysteic acid 184.07 8.01 C4H9NO5S 4.74 -2.72
3  S-Nitrosoglutathione 337.06 0.62 C10H16N4O7S 10.03 2044.09
4 LysoPA(18:1(9Z)/0:0) 459.25 8.01 C21H41O7P 1.01 -2.12
5 LysoPE(P-16:0/0:0) 438.30 8.35 C21H44NO6P 1.40 -2.47
6 LysoPC(16:0/0:0) 496.34 8.16 C24H50NO7P 38.02 -2.29
7 LysoPC(P-18:0/0:0) 508.38 8.55 C26H54NO6P 3.19 -2.96
8 DG(18:3(6Z,9Z,12Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z)/0:0) 685.44 11.50 C43H66O5 1.24 3.42
9 Bisdiphosphoinositol tetrakisphosphate 820.81 0.55 C6H20O30P8 1.24 2.67
10 PE(22:0/24:0) 888.80 0.55 C51H102NO8P 1.36 2.56
11 PC(24:0/24:1(15Z)) 956.79 0.55 C56H110NO8P 1.29 2.36
12 Pyruvic acid 174.96 0.49 C3H4O3 4.84 15.21
13 D-Ribose 130.97 0.49 C5H10O5 2.13 9.07
14  L-Targinine 187.07 0.60 C7H16N4O2 1.68 53.79
15  N(omega)-Hydroxyarginine 224.98 0.63 C6H14N4O3 1.26 -9.13
16 Citric acid 191.02 0.64 C6H8O7 2.66 6.12
17 Gamma-Glutamylserine 269.08 0.60 C8H14N2O6 4.21 52.50
18 5-Thymidylic acid 357.03 0.63 C10H15N2O8P 3.53 2.17
19 Inosinic acid 329.04 0.59 C10H13N4O8P 5.62 124.17
20 SN38 glucuronide 549.05 0.64 C28H28N2O11 1.14 15.33
21 PC(O-22:1(13Z)/22:3(10Z,13Z,16Z)) 878.77 0.48 C52H98NO7P 1.63 4.20
22 PE(22:0/24:1(15Z)) 866.78 0.53 C51H100NO8P 1.91 3.57
23 Octanoyl-CoA 874.24 0.48 C29H50N7O17P3S 1.21 3.57
24 PC(24:0/24:0) 1002.76 0.53 C56H112NO8P 1.30 2.14
  1. Fold change refers to the “RA EP group vs. healthy group” change value
  2. LysoPA Lysophosphatidic acid, LysoPE Lysophosphatidylethanolamine, LysoPC Lysophosphatidylcholine, DG Diacyl glycerol, PE Phosphatidylethanolamine, PC Phosphatidylcholine