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Fig. 1 | Chinese Medicine

Fig. 1

From: Salidroside attenuates neuronal ferroptosis by activating the Nrf2/HO1 signaling pathway in Aβ1-42-induced Alzheimer’s disease mice and glutamate-injured HT22 cells

Fig. 1

Salidroside increases the cell viability in Glu-injured HT22 cells. A Chemical structure of salidroside. B Mouse genotypes were confirmed by PCR of tail DNA. C The animal experimental process. D Effects of different concentrations Glu on the HT22 cells viability. ***P < 0.001 when compared with the control group (Glu = 0 mM). E Effects of different concentrations salidroside on the HT22 cells viability. F Effects of different concentrations salidroside on the viability of Glu-injured HT22 cells. *P < 0.05, **P < 0.01, ***P < 0.001, “ns” means no significant difference (P >  0.05). G Effects of salidroside and Fer-1 on the viability of Glu-injured HT22 cells. *P < 0.05, **P < 0.01, ***P < 0.001. H The CCK-8 assay results were confirmed by the cell LDH assay. *P < 0.05, **P < 0.01, ***P < 0.001, “ns” means no significant difference (P >  0.05). I TEM showed the ultrastructural changes of mitochondria in each group. The Glu group showed that mitochondria became smaller and the density of bilayer membrane increased. Salidroside and fer-1 could improve this change

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Chinese Medicine

ISSN: 1749-8546

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