Fig. 8
Salidroside regulated neurons mitochondrial ultrastructural changes and GPX4 expression in WT mice, but not in Nrf2−/−mice. A Ultrastructural changes in neuronal mitochondria in the hippocampal CA1 region. The mitochondria observed in the Aβ1−42 group were smaller than those in the control group, and the cristae of mitochondria in the Aβ1−42 group were decreased. Treatment with salidroside attenuated these morphological changes in WT mice but not in Nrf2−/− mice. Scale bars: 500 nm. B Immunohistochemistry showed that salidroside increased the expression of GPX4 in hippocampus and cortex in Aβ1−42 induced WT mice, but this change was not observed in Nrf2 −/− mice. Scale bar: 100 μm