Skip to main content
Fig. 1 | Chinese Medicine

Fig. 1

From: An anti-inflammatory and anti-fibrotic proprietary Chinese medicine nasal spray designated as Allergic Rhinitis Nose Drops (ARND) with potential to prevent SARS-CoV-2 coronavirus infection by targeting RBD (Delta)- angiotensin converting enzyme 2 (ACE2) binding

Fig. 1

Network analysis of ARND’s targets acting on genes of the highly pathogenic and deadly human coronaviruses, namely SARS-CoV-2. A Venn diagram indicating intersection between ARND targeted genes (blue circle) and COVID-19 related genes (red circle). Under the condition of oral bioavailability (OB) > 30% and drug-likeness (DL) > 0.18, there were 118 gene targets commonly regulated by ARND and SARS-CoV-2. B Sankey diagram showing the drug–chemical-target relationships for ARND in which the height of the grid is proportional to the related score. The results showed that 118 gene targets related to COVID-19 were potentially regulated by 52 chemicals of 11 drugs in ARND.The herbs in ARND are numbered as follows. 1 = Centipedae Herba, 2 = Coptidis Rhizoma, 3 = Lonicerae Japonicae Flos, 4 = Scutellariae Radix, 5 = Menthae Haplocalycis Herba, 6 = Platycodonis Radix, 7 = Saposhnikoviae Radix, 8 = Citri Reticuulatae Pericarpium, 9 = Paeoniae Radix Alba, 10 = Glycyrrhizae Radix et Rhizoma, and 11 = Jujubae Fructus. C PPI network based on 118 intersected targets. The protein nodes are ordered by degree according to color from deep red (high degree) to light yellow (low degree). According to the degree, the gene targets with a degree greater than 43.864 are shown in a column chart (Additional file_METHOD_FIG_A1_TABLES_A1_12: Table A5)

Back to article page

Chinese Medicine

ISSN: 1749-8546

Contact us