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Table 5 Angiogenesis

From: Traditional Chinese medicine promotes bone regeneration in bone tissue engineering

Active components Biomaterials Experimental model Efficacy References
Icariin CPC rBMSC, 20 µM; OVX rat calvarial defect model Up-regulating VEGF and ANG1 [143]
SMC-PHBHHx scaffold BMSC, 10−6 mol/L; rat calvarial defects model Up-regulating VEGF, and FGF [20]
45S5 Bioglass rADSC, 10−7 mol/L; rat calvarial defects model Up-regulating VEGF [144]
Icaritin PLGA/TCP BMSC, BMC 0.052: 100 (powder weight to solution volume); rat calvarial defect model Up-regulating OCN [145]
PLGA/TCP Rabbit ulnar segmental bone defect N/A [148]
PLGA/TCP rBMSC, 1 µM; SAON rabbit both distal and proximal femur defect model MEK/ERK and PI3K/Akt/eNOS-dependent signal pathways [146, 147]
Hydroxy safflower yellow A BG rBMSCs, HUVECs; rat calvarial defects model Up-regulating HIF-1α [96]
Silibinin Zn C3H10T1/2, MG-63; 60 µM; 3, 7 d Up-regulating VEGF and ANG1 [120]
Resveratrol PEGDA/TCS Hydrogel rBMSCs, HUVECs, 800 µM; rat tibia defect model Up-regulating CD31 [84]
PLGA microsphere hMSCs, hTHP-1 monocytes, 25 µM Up-regulating VEGF [108]