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Table 6 Osteoclastogenesis

From: Traditional Chinese medicine promotes bone regeneration in bone tissue engineering

Active components Biomaterials Experimental model Efficacy References
Icariin CPC rBMSC, 20 µM; OVX rat calvarial defect model Down-regulating RANKL [143]
Icaritin PLGA/TCP BMSC, BMC 0.052: 100 (powder weight to solution volume); rat calvarial defect model Down-regulating RANKL/OPG [145]
Quercetin Ti RAW264.7, 1 mM; rabbit tibia model Down-regulating Trap, CalcR, Ctsk, H+ATPase, MMP-9 and RANKL [151]
Ursolic acid Ti particle RAW264.7, BMMs, 5 µM; mouse calvarial bone defect model Down-regulating NFATc1, NF-kB and JNK signaling [152]
Epigallocatechin Ti-6Al-4 V hADSCs, Raw264.7, 0.1, 0.5, 1 mg/mL; rabbit tibias defect model Down-regulating TRAP, CTSK, and RAW264.7 number [112]
PLLA ADSCs, Raw 264.7, 1 mg/mL; mouse calvarial defect Down-regulating RAW264.7 number [113]