Table 6 Osteoclastogenesis

Icariin

CPC

rBMSC, 20 µM; OVX rat calvarial defect model

Down-regulating RANKL

[143]

Icaritin

PLGA/TCP

BMSC, BMC 0.052: 100 (powder weight to solution volume); rat calvarial defect model

Down-regulating RANKL/OPG

[145]

Quercetin

Ti

RAW264.7, 1 mM; rabbit tibia model

Down-regulating Trap, CalcR, Ctsk, H⁺ATPase, MMP-9 and RANKL

[151]

Ursolic acid

Ti particle

RAW264.7, BMMs, 5 µM; mouse calvarial bone defect model

Down-regulating NFATc1, NF-kB and JNK signaling

[152]

Epigallocatechin

Ti-6Al-4 V

hADSCs, Raw264.7, 0.1, 0.5, 1 mg/mL; rabbit tibias defect model

Down-regulating TRAP, CTSK, and RAW264.7 number

[112]

PLLA

ADSCs, Raw 264.7, 1 mg/mL; mouse calvarial defect

Down-regulating RAW264.7 number

[113]