Table 8 Others

Anti-bacterial properties

Silibinin

Zn

C3H10T1/2, MG-63, 60 µM

E. coli (Gram-negative) and S. aureus (Gram-positive) strains

[120]

Anti-bacterial properties

Berberine

Negatively charged O-carboxymethyl chitosan microspheres

MG-63, rBMSCs; rabbit lateral femoral condyle model

S. aureus

[90]

Anti-bacterial properties

Quercetin

Ti-6Al-4 V

MC3T3-E1

S. epidermidis

[160]

Anti-apoptotic properties

Ginsenoside Rg1

Alginate-CS microspheres

hBMSC, 2 g

Up-regulating Nestin, NSE, GFAP and Bcl-2 and down-regulating Bax

[161]

Anti-inflammatory properties

Resveratrol

PLA–Gel porous nano-scaffold

Rat articular cartilage defect model

Up-regulating SIRT1

[138]

Anti-inflammatory and anti-apoptotic properties

Baicalin

TPGS polymeric micelles

Rat gingival fibroblasts, 20 mg/mL; rat periodontal disease model

Down-regulating TNF-α, IL-1β, and the number of inflammatory cells

[162]

Anti-inflammatory properties

Tetrandrine

PLLA

RAW 264.7, 20 mg; rat model

Down-regulating NO, TNF-a, IL-6, iNOS, and COX-2

[163]

Anti-inflammatory properties

Ginsenoside Rb1

MSCS/PCL

hDPSCs, 5% v/v; rabbit femoral defect model

Up-regulating IL-1RA and down-regulating IL-1β

[62]

Anti-inflammatory properties

Resveratrol

COLI/PAA

Chondrocytes, BMSCs, 0.5%; rabbit osteochondral defects model

Down-regulating IL-1β, MMP-13 and COX-2

[137]

Anti-inflammatory properties

Resveratrol

PLGA microsphere

hMSCs, hTHP-1 monocytes, 25 µM

Up-regulating IL-10 and down-regulating TNF-α and IL-6

[108]

Anti-inflammatory properties

Epigallocatechin gallate

Ti-6Al-4 V

hADSCs, Raw264.7, 0.1, 0.5, 1 mg/mL; rabbit tibias defect model

Up-regulating IL-10 and down-regulating IL-6

[112]

Anti-inflammatory properties

Epigallocatechin gallate

Hyaluronic acid

Chondrocytes, 50 µM; mouse osteoarthritis model

Down-regulating IL-1β and TNF-α,

[139]

Anti-oxidant and anti-inflammatory properties

Epigallocatechin gallate

POSS

MC3T3-E1, 6 wt%

Down-regulating IL-6

[114]

Anti-oxidant and anti-inflammatory properties

Epigallocatechin gallate

Gel sponges

UMR106, 0.07 mg; rat calvarial defects model

Down-regulating 4-HNE

[85]

Anti-oxidant properties

Resveratrol

PLA/OMMT

HASCs, 0.1 wt%

N/A

[110]

Anti-oxidant properties

Quercetin

CS/COL hydrogel

hPDLSC; 100 µM

N/A

[164]

Anti-oxidant properties

Epigallocatechin gallate

PLLA

ADSCs, Raw 264.7, 1 mg/mL; mouse calvarial defect

N/A

[113]