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Table 8 Others

From: Traditional Chinese medicine promotes bone regeneration in bone tissue engineering

Mechanism Active components Biomaterials Experimental models Efficacy References
Anti-bacterial properties Silibinin Zn C3H10T1/2, MG-63, 60 µM E. coli (Gram-negative) and S. aureus (Gram-positive) strains [120]
Anti-bacterial properties Berberine Negatively charged O-carboxymethyl chitosan microspheres MG-63, rBMSCs; rabbit lateral femoral condyle model S. aureus [90]
Anti-bacterial properties Quercetin Ti-6Al-4 V MC3T3-E1 S. epidermidis [160]
Anti-apoptotic properties Ginsenoside Rg1 Alginate-CS microspheres hBMSC, 2 g Up-regulating Nestin, NSE, GFAP and Bcl-2 and down-regulating Bax [161]
Anti-inflammatory properties Resveratrol PLA–Gel porous nano-scaffold Rat articular cartilage defect model Up-regulating SIRT1 [138]
Anti-inflammatory and anti-apoptotic properties Baicalin TPGS polymeric micelles Rat gingival fibroblasts, 20 mg/mL; rat periodontal disease model Down-regulating TNF-α, IL-1β, and the number of inflammatory cells [162]
Anti-inflammatory properties Tetrandrine PLLA RAW 264.7, 20 mg; rat model Down-regulating NO, TNF-a, IL-6, iNOS, and COX-2 [163]
Anti-inflammatory properties Ginsenoside Rb1 MSCS/PCL hDPSCs, 5% v/v; rabbit femoral defect model Up-regulating IL-1RA and down-regulating IL-1β [62]
Anti-inflammatory properties Resveratrol COLI/PAA Chondrocytes, BMSCs, 0.5%; rabbit osteochondral defects model Down-regulating IL-1β, MMP-13 and COX-2 [137]
Anti-inflammatory properties Resveratrol PLGA microsphere hMSCs, hTHP-1 monocytes, 25 µM Up-regulating IL-10 and down-regulating TNF-α and IL-6 [108]
Anti-inflammatory properties Epigallocatechin gallate Ti-6Al-4 V hADSCs, Raw264.7, 0.1, 0.5, 1 mg/mL; rabbit tibias defect model Up-regulating IL-10 and down-regulating IL-6 [112]
Anti-inflammatory properties Epigallocatechin gallate Hyaluronic acid Chondrocytes, 50 µM; mouse osteoarthritis model Down-regulating IL-1β and TNF-α, [139]
Anti-oxidant and anti-inflammatory properties Epigallocatechin gallate POSS MC3T3-E1, 6 wt% Down-regulating IL-6 [114]
Anti-oxidant and anti-inflammatory properties Epigallocatechin gallate Gel sponges UMR106, 0.07 mg; rat calvarial defects model Down-regulating 4-HNE [85]
Anti-oxidant properties Resveratrol PLA/OMMT HASCs, 0.1 wt% N/A [110]
Anti-oxidant properties Quercetin CS/COL hydrogel hPDLSC; 100 µM N/A [164]
Anti-oxidant properties Epigallocatechin gallate PLLA ADSCs, Raw 264.7, 1 mg/mL; mouse calvarial defect N/A [113]