Fig. 4From: Frontier progress of the combination of modern medicine and traditional Chinese medicine in the treatment of hepatocellular carcinomaRelated pathways and mechanisms involved in the treatment of HCC Integrated traditional Chinese and modern medicine inhibits MDR pathway by reversing P-gp. And through the EGFR and VEGF pathway inhibit the cell proliferation, tumor micro-vessel production and metastasis of HCC, regulate autophagy and induce apoptosis of hepatoma cells. TCM increases ROS production and induces ferroptosis in HCC cells. TCM promotes the curative effect of PD-1 or PD-L1, so as to enhance the immunity of tumor-bearing mice, improve the tumor micro-environment, realize the anti-tumor and improve drug resistance by enhancing chemotherapy, molecular targeted drugs and ICIsBack to article page