Natural products: potential drugs for the treatment of renal fibrosis

Zhou, Zijun; Qiao, Yanheng; Zhao, Yanru; Chen, Xin; Li, Jie; Zhang, Hanqing; Lan, Qiumei; Yang, Bo

doi:10.1186/s13020-022-00646-z

Chinese Medicine

Table 1 Natural products and renal fibrosis

From: Natural products: potential drugs for the treatment of renal fibrosis

Natural products	Model	Signaling pathway	Refs.
Quercetin	UUO mice Mouse macrophage line cells	M1/M2 macrophage polarization	[26]
	UUO rats NRK-52E cells	Sonic Hedgehog pathway	[27]
	UUO rats NRK-52E cells	SIRT1/PINK1/Parkin pathway	[28]
Puerarin	UUO mice HK-2 cells	Oxidative stress MAPK pathway	[29]
Puerarin	UUO mice	NF-κB p65/STAT3 pathway TGF-β/Smad pathway	[30]
Dihydromyricetin	UUO mice HK-2 cells	miR-34a pathway	[31]
Dihydromyricetin	Human glomerular mesangial cells	Nrf2/HO-1 pathway	[33]
Calycosin	DN rats	IL-33/ST2 pathway	[34]
Isoliquiritigenin	Mouse bone marrow-derived macrophage UUO mice	Mincle/Syk/NF-κB pathway M1 macrophage polarization inflammation	[34]
	NRK-52E cells DN mice	SIRT1 pathway Inflammation Oxidative stress	[35]
	HK-2 cells UUO mice	Cellular senescence	[36]
5,7,3ʹ,4ʹ,5ʹ-pentahydroxy flavanone	5/6 nephrectomized rats NRK-52E cells	AHR pathway	[37]
Barleriside A	5/6 nephrectomized rats NRK-52E cells	AHR pathway	[37]
Rhoifolin	5/6 nephrectomized rats NRK-52E cells	AHR pathway	[37]
5,6,7,8,3ʹ,4ʹ-hexa-methoxyflavone	5/6 nephrectomized rats HK-2 cells	AHR pathway	[38]
Curcumin	UUO rats	NLRP3 inflammasome PI3K/AKT/mTOR pathway	[42]
	Kidney transplantation rats	Autophagy	[43]
	Cisplatin-induced rats	Oxidative stress	[44]
Resveratrol	UUO rats	MAPK pathway PI3K/AKT pathway Wnt/β-catenin pathway JAK2/STAT3 pathway	[45]
	Aged mice	Renin–angiotensin System	[46]
	Concanavalin A-induced Aged mice	SIRT1/Klotho pathway Oxidative stress	[47]
Epigallocatechin gallate	Cadmium-induced rats	TGF-β1/microRNA pathway Oxidative stress	[48]
	Dahl salt-sensitive rats NRK-49F cells	Inflammation Oxidative stress Apoptosis	[49]
	DN mice HEK293 cells	Notch pathway TGF-β/Smad3 pathway	[50]
Salvianolic acid A	5/6 nephrectomized rats HK-2 cells	p38 MAPK/NF-κB	[51]
Schisandrin B	UUO mice HK-2 cells NRK-52E cells HEK-293 T cells	TGF-β1 pathway miR-30e pathway	[52]
Poricoic acid A	UUO mice NRK-52E cells NRK-49F cells	TPH-1 pathway Wnt/β-catenin pathway	[56]
Poricoic acid A	5/6 nephrectomized rats UUO rats NRK-49F cells	TGF-β1/Smad3 pathway AMPK pathway	[57]
Poricoic acid ZC	UUO mice HK-2 cells	TGF-β/Smad pathway Wnt/β-catenin pathway	[58]
Poricoic acid ZD	UUO mice HK-2 cells	TGF-β/Smad pathway Wnt/β-catenin pathway	[58]
Poricoic acid ZE	UUO mice HK-2 cells	TGF-β/Smad pathway Wnt/β-catenin pathway	[58]
Poricoic acid ZG	HK-2 cells	TGF-β/Smad pathway Wnt/β-catenin pathway	[59]
Poricoic acid ZH	HK-2 cells	TGF-β/Smad pathway Wnt/β-catenin pathway	[59]
Poricoic acid ZI	UUO mice HK-2 cells NRK-52E cells NRK-49F cells	TGF-β/Smad pathway Wnt/β-catenin pathway	[60]
Poricoic acid ZM	UUO mice HK-2 cells	NF-κB pathway Keap1/Nrf2 pathway AHR pathway	[61]
Poricoic acid ZP	UUO mice HK-2 cells	NF-κB pathway Keap1/Nrf2 pathway AHR pathway	[61]
Alisol B 23-acetate	5/6 nephrectomized rats UUO rats NRK-52E cells NRK-49F cells	Gut–kidney axis RAS TGF-β/Smad pathway Wnt/β-catenin pathway	[62]
Triptolide	Col4a3^–/– mice DN mice Folic acid-induced mice HK-2 cells	PTEN pathway	[63]
Triptolide	DN rats Human mesangial cells	miR-141-3p/PTEN/Akt/mTOR pathway	[64]
Ligustrazine	UUO rats	TGF-β1/CTGF pathway HGF pathway	[67]
Oxymatrine	NRK-52E cells	SnoN pathway	[68]
Oxymatrine	db/db mice NRK-52E cells	Id2 pathway Twist pathway	[69]
Leonurine	UUO mice	TGF-β pathway NF-κB pathway	[70]
Berberine	DN mice NRK-52E cells	Nrf2/HO-1 pathway TGF-β/Smad pathway	[71]
Berberine	DN mice Mouse renal tubular epithelial cells	Notch/snail pathway	[72]
Astragaloside IV	DN rats	TRX antioxidant system NLR pathway	[74]
	UUO mice	TLR4/NF-κB pathway	[75]
	HK-2 cells	mTORC1/p70S6K pathway	[76]
	Tacrolimus-induced mice	p62-Keap1-Nrf2 pathway	[77]
Salidroside	UUO mice Folic acid-induced mice HK-2 cells	TLR4/MAPK/NF-κB pathway	[78]
	DN mice	SIRT1/PGC-1α pathway	[79]
	Adriamycin‐induced mice	Wnt/β-catenin pathway	[80]
Dioscin	Fructose-induced rats	SIRT3 pathway TGF-β1/Smad3 pathway	[81]
Tanshinone IIA	5/6 nephrectomized rats	TGF-β/Smad pathway NF-κB pathway	[84]
	Folic acid-induced mice IRI mice	GSK3β pathway MAPK pathway	[85]
	DN rats	PERK pathway Oxidative stress	[86]
Emodin	DN rats	AMPK/mTOR pathway	[87]
	Adriamycin-induced rats with unilateral nephrectomy HK-2 cells	BMP7/TGF-β1 pathway Autophagy	[88]
	UUO rats NRK-49F cells	EZH2 pathway	[89]
Chrysophanol	UUO mice HK-2 cells	TGF-β/Smad pathway	[90]

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