Fig. 11

The expression of MDR1 and MRP1 and the sensitivity to 5-Fu in BGC823/5–Fu-CSCs when knockdown of Nrf2. A The expression of Nrf2 after intervened with Nrf2 siRNA. The si-Nrf2-3 gained the most Nrf2 knockdown efficiency and it was used in the subsequent experiments. B The expression of P-gp (encoded by MDR1) and MRP1. C The cell viability of BGC823/5–Fu-CSCs. B, C The duration of administration was 48 h