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Table 1 The pharmacokinetic parameters of nine components of RMC extracts between N-RMC and BHS-RMC group (n = 6)

From: Integrating pharmacokinetics and network analysis to investigate the mechanism of Moutan Cortex in blood-heat and blood stasis syndrome

Analyte

Group

Pharmacokinetics parameters

T1/2

(h)

Tmax

(h)

Cmax

(μg/mL)

AUC

(μg/mL*h)

MRT

(h)

CL/F

(mL/min/kg)

Gallic acid

N-RMC

10.76 ± 0.87◆

0.75 ± 0.00◆

126.96 ± 2.90◆

1018.73 ± 26.63

17.30 ± 0.80◆

58.93 ± 1.58

BHS-RMC

6.33 ± 0.45↓

1.00 ± 0.00↑

180.13 ± 11.06↑

1067.98 ± 72.88↑

10.02 ± 0.96↓

56.40 ± 3.79↓

5-HMF

N-RMC

3.20 ± 0.03◆◆

3.00 ± 0.00◆◆

413.25 ± 2.01◆◆

1563.50 ± 4.63◆◆

4.55 ± 0.03◆

38.38 ± 0.11◆◆

BHS-RMC

7.33 ± 2.10↑

0.75 ± 0.00↓

111.37 ± 7.25↓

740.76 ± 20.26↓

7.47 ± 0.48↑

81.05 ± 2.25↑

Oxypaeoniflorin

N-RMC

3.08 ± 0.98◆◆

4.00 ± 0.00◆◆

10.23 ± 0.11◆◆

45.72 ± 1.4◆

5.53 ± 0.50◆◆

1313.57 ± 40.19◆

BHS-RMC

15.13 ± 2.25↑

0.50 ± 0.00↓

2.09 ± 0.04↓

24.16 ± 3.09↓

21.59 ± 3.42↑

2519.95 ± 343.95↑

3,8-Dihydroxy-2-methylchromone

N-RMC

4.73 ± 0.29◆◆

0.75 ± 0.00

115.71 ± 2.12◆

660.32 ± 29.92◆

6.90 ± 0.68◆◆

91.01 ± 4.00◆◆◆

BHS-RMC

19.01 ± 1.78↑

0.75 ± 0.00

134.00 ± 3.26↑

756.93 ± 8.72↑

14.06 ± 1.07↑

79.28 ± 0.92↓

Paeoniflorin

N-RMC

9.75 ± 0.47◆◆

0.50 ± 0.00◆

201.57 ± 1.86◆◆

1449.69 ± 62.31◆◆

15.53 ± 0.94◆◆

41.45 ± 1.78◆◆

BHS-RMC

3.60 ± 0.31↓

0.75 ± 0.00↑

84.23 ± 1.99↓

298.12 ± 7.60↓

5.06 ± 0.22↓

201.37 ± 5.16↑

Benzoic acid

N-RMC

11.11 ± 1.88

4.00 ± 0.00◆

143.65 ± 4.48◆

1877.15 ± 216.74◆

16.96 ± 2.76◆

32.30 ± 3.70◆

BHS-RMC

10.04 ± 0.67↓

3.00 ± 0.00↓

212.92 ± 5.26↑

2319.78 ± 71.29↑

13.26 ± 0.79↓

25.88 ± 0.80↓

Methylparaben

N-RMC

4.93 ± 0.23◆◆

0.75 ± 0.00◆

6.35 ± 0.53◆◆

22.82 ± 1.34◆

7.91 ± 0.56◆◆

2636.68 ± 156.55◆

BHS-RMC

17.91 ± 0.84↑

1.00 ± 0.00↑

2.16 ± 0.11↓

39.87 ± 1.34↑

27.07 ± 1.16↑

1506.43 ± 50.68↓

Quercetin

N-RMC

9.97 ± 0.35◆

4.00 ± 0.00

643.27 ± 19.81◆

7338.63 ± 165.50◆

16.64 ± 0.56◆

8.18 ± 0.18◆

BHS-RMC

15.49 ± 0.54↑

4.00 ± 0.00

739.851 ± 4.17↑

10,036.28 ± 171.6↑

20.45 ± 0.66↑

5.98 ± 0.10↓

Paeonol

N-RMC

7.84 ± 0.08◆

0.75 ± 0.00

11.76 ± 0.13◆

106.52 ± 1.23◆◆

12.11 ± 0.17◆◆

563.34 ± 6.49◆◆

BHS-RMC

4.37 ± 0.15↓

0.75 ± 0.00

10.37 ± 0.23↓

45.54 ± 0.83↓

4.63 ± 0.12↓

12,450.58 ± 8613↑

  1. ◆indicates that there is a significant difference between the N-RMC and the BHS-RMC (p < 0.05), and ◆◆indicates that the N-RMC and the BHS-RMC are significantly different (p < 0.01), ↑ was represented rising in BHS-RMC comparing N-RMC, ↓ was represented declining