Analyte | Group | Pharmacokinetics parameters | |||||
---|---|---|---|---|---|---|---|
T1/2 (h) | Tmax (h) | Cmax (μg/mL) | AUC (μg/mL*h) | MRT (h) | CL/F (mL/min/kg) | ||
Gallic acid | N-RMC | 10.76 ± 0.87◆ | 0.75 ± 0.00◆ | 126.96 ± 2.90◆ | 1018.73 ± 26.63 | 17.30 ± 0.80◆ | 58.93 ± 1.58 |
BHS-RMC | 6.33 ± 0.45↓ | 1.00 ± 0.00↑ | 180.13 ± 11.06↑ | 1067.98 ± 72.88↑ | 10.02 ± 0.96↓ | 56.40 ± 3.79↓ | |
5-HMF | N-RMC | 3.20 ± 0.03◆◆ | 3.00 ± 0.00◆◆ | 413.25 ± 2.01◆◆ | 1563.50 ± 4.63◆◆ | 4.55 ± 0.03◆ | 38.38 ± 0.11◆◆ |
BHS-RMC | 7.33 ± 2.10↑ | 0.75 ± 0.00↓ | 111.37 ± 7.25↓ | 740.76 ± 20.26↓ | 7.47 ± 0.48↑ | 81.05 ± 2.25↑ | |
Oxypaeoniflorin | N-RMC | 3.08 ± 0.98◆◆ | 4.00 ± 0.00◆◆ | 10.23 ± 0.11◆◆ | 45.72 ± 1.4◆ | 5.53 ± 0.50◆◆ | 1313.57 ± 40.19◆ |
BHS-RMC | 15.13 ± 2.25↑ | 0.50 ± 0.00↓ | 2.09 ± 0.04↓ | 24.16 ± 3.09↓ | 21.59 ± 3.42↑ | 2519.95 ± 343.95↑ | |
3,8-Dihydroxy-2-methylchromone | N-RMC | 4.73 ± 0.29◆◆ | 0.75 ± 0.00 | 115.71 ± 2.12◆ | 660.32 ± 29.92◆ | 6.90 ± 0.68◆◆ | 91.01 ± 4.00◆◆◆ |
BHS-RMC | 19.01 ± 1.78↑ | 0.75 ± 0.00 | 134.00 ± 3.26↑ | 756.93 ± 8.72↑ | 14.06 ± 1.07↑ | 79.28 ± 0.92↓ | |
Paeoniflorin | N-RMC | 9.75 ± 0.47◆◆ | 0.50 ± 0.00◆ | 201.57 ± 1.86◆◆ | 1449.69 ± 62.31◆◆ | 15.53 ± 0.94◆◆ | 41.45 ± 1.78◆◆ |
BHS-RMC | 3.60 ± 0.31↓ | 0.75 ± 0.00↑ | 84.23 ± 1.99↓ | 298.12 ± 7.60↓ | 5.06 ± 0.22↓ | 201.37 ± 5.16↑ | |
Benzoic acid | N-RMC | 11.11 ± 1.88 | 4.00 ± 0.00◆ | 143.65 ± 4.48◆ | 1877.15 ± 216.74◆ | 16.96 ± 2.76◆ | 32.30 ± 3.70◆ |
BHS-RMC | 10.04 ± 0.67↓ | 3.00 ± 0.00↓ | 212.92 ± 5.26↑ | 2319.78 ± 71.29↑ | 13.26 ± 0.79↓ | 25.88 ± 0.80↓ | |
Methylparaben | N-RMC | 4.93 ± 0.23◆◆ | 0.75 ± 0.00◆ | 6.35 ± 0.53◆◆ | 22.82 ± 1.34◆ | 7.91 ± 0.56◆◆ | 2636.68 ± 156.55◆ |
BHS-RMC | 17.91 ± 0.84↑ | 1.00 ± 0.00↑ | 2.16 ± 0.11↓ | 39.87 ± 1.34↑ | 27.07 ± 1.16↑ | 1506.43 ± 50.68↓ | |
Quercetin | N-RMC | 9.97 ± 0.35◆ | 4.00 ± 0.00 | 643.27 ± 19.81◆ | 7338.63 ± 165.50◆ | 16.64 ± 0.56◆ | 8.18 ± 0.18◆ |
BHS-RMC | 15.49 ± 0.54↑ | 4.00 ± 0.00 | 739.851 ± 4.17↑ | 10,036.28 ± 171.6↑ | 20.45 ± 0.66↑ | 5.98 ± 0.10↓ | |
Paeonol | N-RMC | 7.84 ± 0.08◆ | 0.75 ± 0.00 | 11.76 ± 0.13◆ | 106.52 ± 1.23◆◆ | 12.11 ± 0.17◆◆ | 563.34 ± 6.49◆◆ |
BHS-RMC | 4.37 ± 0.15↓ | 0.75 ± 0.00 | 10.37 ± 0.23↓ | 45.54 ± 0.83↓ | 4.63 ± 0.12↓ | 12,450.58 ± 8613↑ |