Fig. 10

Dose-responses curves of curcumin, piperine, and the combination of curcumin and piperine in the cold plate test (A) and their isobologram (B). Antinociceptive effects are expressed as %MPE. Data are expressed as mean ± S.E.M (n = 10 mice/group). The difference between ED_{50 add} and ED_{50 exp} was analyzed using the unpaired t-test. ***p < 0.001