Fig. 12From: Combination of curcumin and piperine synergistically improves pain-like behaviors in mouse models of pain with no potential CNS side effectsThe effects of curcumin, piperine, and the combination of curcumin and piperine on spontaneous locomotor activity in naïve mice. The behaviors were presented as the duration of climbing (A), locomotion (B), immobility (C), rearing (D), average speed (E), and distance traveled (F). Data are expressed as means ± S.E.M (n = 8 mice/group). Cur300, curcumin 300 mg/kg; Pip100, piperine 100 mg/kg; Cur + Pip1; theoretical ED50 dose in the formalin test; Cur + Pip2; theoretical ED50 dose in the tail-flick testBack to article page