Fig. 13
The effects of curcumin, piperine, and the combination of curcumin and piperine on spontaneous locomotor activity in naïve mice. The behaviors were presented as the frequency of climbing (A), locomotion (B), immobility (C), and rearing (D). Data are expressed as means ± S.E.M (n = 8 mice/group). Cur300, curcumin 300 mg/kg; Pip100, piperine 100 mg/kg; Cur + Pip1; theoretical ED50 dose in the formalin test; Cur + Pip2; theoretical ED50 dose in the tail-flick test