Fig. 3

Dose-responses curves of curcumin, piperine, and the combination of curcumin and piperine in the formalin test (A) and their isobologram (B). Antinociceptive effects are expressed as % antinociception. Data are expressed as means ± S.E.M (n = 8 mice/group). The difference between ED_{50 add} and ED_{50 exp} was analyzed using the unpaired t-test. ***p < 0.001