Fig. 7

Effect of curcumin, piperine and their combination on heat nociception. (A) Experimental setup. (B) Experimental timeline. (C, D, E) Time course of the effect of curcumin (C), piperine (D) and the combination of curcumin and piperine (E) on thermal nociception in mice. The effects of the test compounds were expressed as the time course of tail-flick latency and % maximum possible effects at 60 min post-compound administration. Data are expressed as means ± S.E.M (n = 10 mice/group). The differences between the vehicle-treated group and treatment groups were analyzed using one-way ANOVA followed by Dunnett’s post hoc test. ***p < 0.001; **p < 0.01; *p < 0.05, compared to the control group