Fig. 9From: Combination of curcumin and piperine synergistically improves pain-like behaviors in mouse models of pain with no potential CNS side effectsEffect of curcumin, piperine, and their combination on cold nociception in mice. (A)Experimental setup. (B) Experimental timeline. (C, D, E) The effect of curcumin (C), piperine (D), and their combination (E) on cold nociception is expressed as the %maximum possible effect. Data are expressed as means ± S.E.M (n = 10 mice/group). The differences between the vehicle-treated and treatment groups were analyzed using one-way ANOVA followed by Dunnett’s post hoc test. ***p < 0.001; **p < 0.01, compared to the control groupBack to article page