Table 6 The pharmacokinetic parameters for five analytes in vivo after gavage with various dose BHGZD (n = 8, mean ± SEM)
Analytes | Times of administration | Timosaponin AIII | Glycyrrhizic acid | Liquiritin apioside | Mangiferin | Cinnamic acid |
|---|---|---|---|---|---|---|
Tmax(h) | Single dose | 6.38 ± 1.69 | 5.88 ± 2.85 | 4.00 ± 1.77 | 2.56 ± 1.68 | 0.37 ± 0.35 |
Cmax(ng/mL) | 5.41 ± 1.23 | 15.61 ± 8.97 | 2.74 ± 1.23 | 48.10 ± 52.73 | 53.31 ± 32.64 | |
T1/2(h) | 4.98 ± 1.74 | 2.99 ± 0.82 | 2.65 ± 1.57 | 3.64 ± 4.82 | 2.36 ± 1.03 | |
AUC(0–t) | 35.56 ± 7.99 | 67.29 ± 36.83 | 11.771 ± 5.87 | 265.57 ± 305.54 | 109.70 ± 126.79 | |
AUC(0–∞) | 45.33 ± 13.95 | 91.78 ± 44.19 | 28.06 ± 9.12 | 297.72 ± 297.82 | 307.17 ± 119.68 | |
MRT(0–t) | 7.54 ± 1.15 | 5.06 ± 1.37 | 3.27 ± 0.80 | 3.60 ± 0.75 | 3.66 ± 1.03 | |
MRT(0–∞) | 9.92 ± 2.73 | 5.83 ± 1.42 | 12.17 ± 12.65 | 6.72 ± 6.64 | 10.53 ± 12.52 | |
Vd(L/kg) | 3,132,646 ± 264,876 | 867,518 ± 160,982 | 7,767,546 ± 4,149,931 | 1,049,685 ± 1,125,516 | 598,493 ± 614,714 | |
CL(L/h/kg) | 506,158 ± 133,767 | 288,330 ± 150,321 | 1,293,431 ± 1,002,413 | 228,709 ± 238,817 | 78,418 ± 31,121 | |
Tmax(h) | Multiple dose | 4.62 ± 2.13 | 4.38 ± 1.06 | 3.62 ± 0.51 | 3.88 ± 0.35 | 0.25 ± 0.01 |
Cmax (ng/mL) | 8.31 ± 1.32 | 58.22 ± 21.17 | 12.29 ± 2.01 | 126.74 ± 25.86 | 106.83 ± 21.78 | |
T1/2 (h) | 5.95 ± 2.19 | 2.48 ± 0.90 | 1.18 ± 0.44 | 1.27 ± 0.46 | 4.00 ± 2.81 | |
AUC (0–t) | 69.75 ± 15.18 | 280.22 ± 111.78 | 44.96 ± 10.19 | 538.35 ± 111.04 | 370.40 ± 46.18 | |
AUC (0–∞) | 76.17 ± 14.30 | 306.05 ± 112.46 | 47.91 ± 11.00 | 560.88 ± 135.88 | 443.26 ± 18.09 | |
MRT(0–t) | 9.52 ± 1.90 | 4.92 ± 0.64 | 3.15 ± 0.48 | 3.93 ± 0.49 | 9.64 ± 6.89 | |
MRT(0–∞) | 11.42 ± 2.50 | 5.85 ± 1.08 | 3.46 ± 0.69 | 4.15 ± 0.75 | 10.73 ± 5.54 | |
Vd(L/kg) | 2,313,233 ± 1,127,522 | 290,133 ± 197,532 | 718,240 ± 269,354 | 69,818 ± 16,069 | 455,197 ± 497,001 | |
CL(L/h/kg) | 289,940 ± 55,029 | 77,574 ± 25,214 | 470,072 ± 121,269 | 39,958 ± 8651 | 75,020 ± 55,222 |