Skip to main content

Table 2 Animal models and interventions of MEPs in the treatment of dyslipidemia

From: Medicinal and edible plants in the treatment of dyslipidemia: advances and prospects

No

MEPs

Intervention

Animal model

Dosage

Period

Control

Dosage

References

1

Cinnamomi cortex

Powder

Albino Rats

2 and 4 g/kg

30 days

/

/

[38]

Extract

C57BL/6 J mice

1%

14 weeks

/

/

[39]

Polyphenol

Wistar rats

100 mg/kg

12 weeks

/

/

[40]

Extract

White mice

2 mg, 4 mg and 8 mg/20 g

28 days

/

/

[41]

Extract

Albino Rats

250 and 500 mg/kg

7 days

Atorvastatin

10 mg/kg

[42]

2

Chrysanthemi flos

Extract

SD rats

0.2% and 0.4%

13 weeks

/

/

[50]

Extract

SD rats

1, 2 and 4 g/kg

8 weeks

Fenofibrate

0.02 g/kg

[51]

Flavonoids, luteolin and luteoloside

SD rats

100 mg/kg; 50 mg/kg; 25 mg / kg

6 weeks

Simvastatin

10 mg/kg

[53]

3

Citri sarcodactylis fructus

Polyphenols

mice

50 mg/kg

11 weeks

/

/

[63]

Polyphenols

Wistar rats

20 mg/Kg

90 days

/

/

[64]

Polyphenols

SD rats

10 mg/Kg

4 weeks

/

/

[65]

Naringin

C57BL/6 J Mice

25, 50 and 100 mg/kg

8 weeks

/

/

[66]

4

Crataegi fructus

Extract

SD rats

50 and 100 mg/kg

4 weeks

/

/

[71]

Extract

SD rats

5% and 10%

4 weeks

/

/

[72]

Freeze-dried powder

ApoE-/- mice

1, 2, and 5 g/kg

12 weeks

/

/

[75]

Concentrated juice

KunMing mice

10, 15, and 20 ml/kg

5 weeks

/

/

[76]

Pectin penta-oligogalacturonide

KunMing mice

300 mg/kg

4 weeks

/

/

[77]

Crude glycoprotein

KunMing mice

1.0, 1.5 and 2.0 g/kg

4 weeks

/

/

[78]

Vitexin

C57BL/6 J mice

5 mg/kg

12 weeks

/

/

[79]

Preparation

ApoE − / − mice

/

16 weeks

/

/

[80]

5

Gardeniae fructus

Extract

SD rats

25, 50, and 100 mg/kg

6 weeks

Metformin

100 mg/kg

[87]

Geniposide

Nrf2 − / − C57BL/6 mice

50, 75 and 100 mg/kg

19 h

Fenofibrate

100 mg/kg

[88]

Geniposide

C57BL/6 and ApoE − / − mice

50 mg/kg

13 weeks

/

/

[89]

Geniposide

ApoE − / − mice

50 mg/kg

12 weeks

/

/

[90]

Geniposide

ApoE–/– mice

50 and 100 mg/kg

4 weeks

/

/

[91]

Genipin

SD rats

12.5 and 25 mg/kg

12 days

/

/

[93]

Genipin

C57BL/6 J mice

5 and 20 mg/kg

9 weeks

Rosiglitazone

2 mg/kg

[94]

6

Hippophae fructus

Flavonoids

KunMing mice

100, 200 and 400 mg/kg

42 days

/

/

[100]

Flavonoids

C57BL/6 mice

100 and 300 mg/kg

9 weeks

/

/

[101]

Sterol

SD rats

100, 200 and 400 mg/kg

42 days

Simvastatin

3.5 mg/kg

[104]

7

Mori fructus

Extract

SD rats

4 g/kg

4 weeks

/

/

[110]

Dried fruit

C57BL/6 J mice

100 and 300 mg/kg

3 months

/

/

[112]

Polysaccharides

db/db mice

200, 500 and 800 mg/kg

8 weeks

/

/

[113]

Polysaccharides

Wistar rats

400 mg/kg

7 weeks

/

/

[114]

8

Mori folium

Powder

SD rats

0.9, 0.6, and 0.3 g/kg

5 weeks

Atorvastatin

6.0 mg/kg

[121]

Extract

SD rats

0.5% and 1%

4 weeks

/

/

[122, 123]

Extract

Wistar rats

0.5%, 1% and 2%

10 weeks

/

/

[116]

Flavonoids

db/db mice

180 mg/kg

7 weeks

Metformin

200 mg/kg

[124]

Flavonoids

SD rats

50, 100 and 200 mg/kg

/

Fenofibrate

50 mg/kg

[125]

Polyphenols, fiber

SD rats

0.8, 0.12, 0.48 and 0.6 g/kg

6 weeks

Orlistat

0.0324 g/kg

[126]

Extract

C57BL/6 mice

0.5%, 1.0% and 2.0%

8 weeks

/

/

[127]

Polysaccharides

C57BL/6 mice

200, 400 and 800 mg/kg

8 weeks

Orlistat

25 mg/kg

[128]

9

Nelumbinis folium

Powder

SD rats

600 mg/kg

18 weeks

/

/

[131]

Nuciferine

SD rats

20 mg/kg

8 weeks

/

/

[133]

Nuciferine

C57BL/6 mice

7.5, 15 and 30 mg/kg

8 weeks

Metformin

90 mg/kg

[134]

Nuciferine

C57BL/6 J mice

0.30%

8 weeks

/

/

[136]

Nuciferine

SD rats

10 mg/kg

8 weeks

Simvastatin

10 mg/kg

[137]

10

Citri reticulatae pericarpium

Extract

SD rats

5 g/kg

4 weeks

Simvastatin

4 mg/kg

[146]

Extract

SD rats

1.25, 2.5 and 5 g/kg

4 weeks

Simvastatin

4 mg/kg

[148]

Extract

SD rats

1.25, 2.5 and 5 g/kg

6 weeks

Ezetimibe

1 mg/kg

[149]

Extract

C57BL/6 mice

5 and 10 g/kg

12 weeks

Simvastatin

2 mg/kg

[150]

11

Zanthoxyli pericarpium

Hydroxy-α-sanshool

Wistar rats

9, 18 and 36 mg/kg

4 weeks

Fenofibrate

18 mg/kg

[157]

12

Dioscoreae rhizoma

Diosgenin

Wistar rats

0.50%

6 weeks

/

/

[162]

Resistant starch

golden hamsters

0.5, and 1.5 g/100 g

4 weeks

/

/

[164]

13

Polygonati rhizoma

Extract

SD rats

1, 2 and 4 g/kg

14 weeks

Resveratrol

40 mg/kg

[165]

Extract

SD rats

4 g/kg

14 weeks

Simvastatin

1.8 mg/kg

[170]

Polysaccharides

KunMing mice

200, 400, and 800 mg/kg

14 days

Simvastatin

30 mg/kg

[171]

Polysaccharides

SD rats

120, 240, 480 mg/kg

14 weeks

Simvastatin

1.8 mg/kg

[172]

Saponin

ICR mice

1, 1.5, and 2 g/kg

4 weeks

Metformin

0.5 g/kg

[173]

Syringaresinol-di-o-β-d-glucoside

SPF mice

25, 50 and 75 mg/kg

2 weeks

/

/

[174]

14

Astragali radix

Total flavones

C57BL/6 J mice

5, 25 and 50 mg/kg

8 weeks

Metformin

0.15 g/kg

[182]

Total flavones

ApoE − / − mice

10 and 20 mg/kg

16 weeks

/

/

[183]

Astragaloside IV

SD rats

80 mg/kg

8 weeks

Metformin

200 mg/kg

[186]

15

Puerariae radix

Extract

C5BL/6 mice

100 and 300 mg/kg

16 weeks

Metformin

250 mg/kg

[193]

Puerarin

SD rats

2 g/kg

16 weeks

/

/

[194]

Puerarin

SD rats

100 mg/kg

8 weeks

/

/

[195]

Polysaccharides

db/db mice

100 and 200 mg/kg

6 weeks

Rosiglitazone

10 mg/kg

[187]

PL-S2

Wistar rats

50 mg/kg

3 weeks

Simvastatin

8 mg/kg

[196]

16

Cassiae semen

Extract

SD rats

10 g/kg

4 weeks

Atorvastatin

10 mg/kg

[201]

Extract

SD rats

54, 162 and 486 mg/kg

4 weeks

Atorvastatin

10 mg/kg

[202]

Total aglycones (TA), rubrofusarin-6-β-gentiobioside (RG) and aurantio-obtusin (AO)

C57BL/6 mice

TA 10 g/kg, RG 20 mg/kg, and AO 20 mg/kg

3 weeks

/

/

[203]

Extract

Wistar rats

0.5, 1, and 2 g/kg

6 weeks

Metformin

0.2 g/kg

[204]

Anthraquinone glycoside

SD rats

5, 10 and 20 mg/kg

6 weeks

Polyene phosphatidylcholine

23 mg/kg

[206]

1,8-Dihydroxyanthraquinone

mice

5 mg/kg

6 weeks

/

/

[207]

17

Canavaliae semen

Total terpenoids and total flavonoids

Wistar rats

400 mg/kg

3 weeks

Glibenclamide

5 mg/kg

[213]

Protein extract

SD rats

4 and 6 g/200 g

2 weeks

/

/

[215]

18

Lablab semen album

Extract

C57BL/6 J mice

25 mg/kg

9 weeks

Milk thistle

100 mg/kg

[220]

Extract

C57BL/6 J mice

25, 50 and 100 mg/kg

9 weeks

Milk thistle

100 mg/kg

[221]

19

Persicae semen

Amygdalin

LDLR-/- mice

1, 3 and 10 mg/kg

4 weeks

/

/

[225]

Amygdalin

ApoE-/- mice

0.04 and 0.08 mg/kg

12 weeks

Simvastatin

2.57 mg/kg

[226]

Peach kernel oil

ApoE-/- mice

2 and 5 g/kg

8 weeks

Simvastatin

5 mg/kg

[228]

20

Portulacae Herba

Extract

Wistar rats

400 mg/kg

4 weeks

Atorvastatin

10 mg/kg

[235]

Extract

Wistar rats

10 g/kg

4 weeks

/

/

[236]

Extract

albino rats

5% and 10%

8 weeks

/

/

[237]

Extract

Wistar rats

0.50%

4 weeks

/

/

[238]

Extract

C57BL/6 mice

5% and 10%

12 weeks

/

/

[239]