From: Medicinal and edible plants in the treatment of dyslipidemia: advances and prospects
No | MEPs | Intervention | Animal model | Dosage | Period | Control | Dosage | References |
---|---|---|---|---|---|---|---|---|
1 | Cinnamomi cortex | Powder | Albino Rats | 2 and 4Â g/kg | 30Â days | / | / | [38] |
Extract | C57BL/6Â JÂ mice | 1% | 14Â weeks | / | / | [39] | ||
Polyphenol | Wistar rats | 100Â mg/kg | 12Â weeks | / | / | [40] | ||
Extract | White mice | 2Â mg, 4Â mg and 8Â mg/20Â g | 28Â days | / | / | [41] | ||
Extract | Albino Rats | 250 and 500Â mg/kg | 7Â days | Atorvastatin | 10Â mg/kg | [42] | ||
2 | Chrysanthemi flos | Extract | SD rats | 0.2% and 0.4% | 13Â weeks | / | / | [50] |
Extract | SD rats | 1, 2 and 4Â g/kg | 8Â weeks | Fenofibrate | 0.02Â g/kg | [51] | ||
Flavonoids, luteolin and luteoloside | SD rats | 100Â mg/kg; 50Â mg/kg; 25Â mg / kg | 6Â weeks | Simvastatin | 10Â mg/kg | [53] | ||
3 | Citri sarcodactylis fructus | Polyphenols | mice | 50Â mg/kg | 11Â weeks | / | / | [63] |
Polyphenols | Wistar rats | 20Â mg/Kg | 90Â days | / | / | [64] | ||
Polyphenols | SD rats | 10Â mg/Kg | 4Â weeks | / | / | [65] | ||
Naringin | C57BL/6Â J Mice | 25, 50 and 100Â mg/kg | 8Â weeks | / | / | [66] | ||
4 | Crataegi fructus | Extract | SD rats | 50 and 100Â mg/kg | 4Â weeks | / | / | [71] |
Extract | SD rats | 5% and 10% | 4Â weeks | / | / | [72] | ||
Freeze-dried powder | ApoE-/- mice | 1, 2, and 5Â g/kg | 12Â weeks | / | / | [75] | ||
Concentrated juice | KunMing mice | 10, 15, and 20Â ml/kg | 5Â weeks | / | / | [76] | ||
Pectin penta-oligogalacturonide | KunMing mice | 300Â mg/kg | 4Â weeks | / | / | [77] | ||
Crude glycoprotein | KunMing mice | 1.0, 1.5 and 2.0Â g/kg | 4Â weeks | / | / | [78] | ||
Vitexin | C57BL/6Â J mice | 5Â mg/kg | 12Â weeks | / | / | [79] | ||
Preparation | ApoE − / − mice | / | 16 weeks | / | / | [80] | ||
5 | Gardeniae fructus | Extract | SD rats | 25, 50, and 100Â mg/kg | 6Â weeks | Metformin | 100Â mg/kg | [87] |
Geniposide | Nrf2 − / − C57BL/6 mice | 50, 75 and 100 mg/kg | 19 h | Fenofibrate | 100 mg/kg | [88] | ||
Geniposide | C57BL/6 and ApoE − / − mice | 50 mg/kg | 13 weeks | / | / | [89] | ||
Geniposide | ApoE − / − mice | 50 mg/kg | 12 weeks | / | / | [90] | ||
Geniposide | ApoE–/– mice | 50 and 100 mg/kg | 4 weeks | / | / | [91] | ||
Genipin | SD rats | 12.5 and 25Â mg/kg | 12Â days | / | / | [93] | ||
Genipin | C57BL/6Â J mice | 5 and 20Â mg/kg | 9Â weeks | Rosiglitazone | 2Â mg/kg | [94] | ||
6 | Hippophae fructus | Flavonoids | KunMing mice | 100, 200 and 400Â mg/kg | 42Â days | / | / | [100] |
Flavonoids | C57BL/6 mice | 100 and 300 mg/kg | 9 weeks | / | / | [101] | ||
Sterol | SD rats | 100, 200 and 400Â mg/kg | 42Â days | Simvastatin | 3.5Â mg/kg | [104] | ||
7 | Mori fructus | Extract | SD rats | 4Â g/kg | 4Â weeks | / | / | [110] |
Dried fruit | C57BL/6Â J mice | 100Â and 300Â mg/kg | 3Â months | / | / | [112] | ||
Polysaccharides | db/db mice | 200, 500 and 800 mg/kg | 8 weeks | / | / | [113] | ||
Polysaccharides | Wistar rats | 400Â mg/kg | 7Â weeks | / | / | [114] | ||
8 | Mori folium | Powder | SD rats | 0.9, 0.6, and 0.3Â g/kg | 5Â weeks | Atorvastatin | 6.0Â mg/kg | [121] |
Extract | SD rats | 0.5%Â and 1% | 4Â weeks | / | / | |||
Extract | Wistar rats | 0.5%, 1%Â and 2% | 10Â weeks | / | / | [116] | ||
Flavonoids | db/db mice | 180Â mg/kg | 7Â weeks | Metformin | 200Â mg/kg | [124] | ||
Flavonoids | SD rats | 50, 100 and 200Â mg/kg | / | Fenofibrate | 50Â mg/kg | [125] | ||
Polyphenols, fiber | SD rats | 0.8, 0.12, 0.48 and 0.6Â g/kg | 6Â weeks | Orlistat | 0.0324Â g/kg | [126] | ||
Extract | C57BL/6 mice | 0.5%, 1.0% and 2.0% | 8Â weeks | / | / | [127] | ||
Polysaccharides | C57BL/6 mice | 200, 400 and 800Â mg/kg | 8Â weeks | Orlistat | 25Â mg/kg | [128] | ||
9 | Nelumbinis folium | Powder | SD rats | 600Â mg/kg | 18Â weeks | / | / | [131] |
Nuciferine | SD rats | 20Â mg/kg | 8Â weeks | / | / | [133] | ||
Nuciferine | C57BL/6 mice | 7.5, 15 and 30Â mg/kg | 8Â weeks | Metformin | 90Â mg/kg | [134] | ||
Nuciferine | C57BL/6Â J mice | 0.30% | 8Â weeks | / | / | [136] | ||
Nuciferine | SD rats | 10Â mg/kg | 8Â weeks | Simvastatin | 10Â mg/kg | [137] | ||
10 | Citri reticulatae pericarpium | Extract | SD rats | 5Â g/kg | 4Â weeks | Simvastatin | 4Â mg/kg | [146] |
Extract | SD rats | 1.25, 2.5 and 5Â g/kg | 4Â weeks | Simvastatin | 4Â mg/kg | [148] | ||
Extract | SD rats | 1.25, 2.5 and 5Â g/kg | 6Â weeks | Ezetimibe | 1Â mg/kg | [149] | ||
Extract | C57BL/6 mice | 5 and 10Â g/kg | 12Â weeks | Simvastatin | 2Â mg/kg | [150] | ||
11 | Zanthoxyli pericarpium | Hydroxy-α-sanshool | Wistar rats | 9, 18 and 36 mg/kg | 4 weeks | Fenofibrate | 18 mg/kg | [157] |
12 | Dioscoreae rhizoma | Diosgenin | Wistar rats | 0.50% | 6Â weeks | / | / | [162] |
Resistant starch | golden hamsters | 0.5, and 1.5Â g/100Â g | 4Â weeks | / | / | [164] | ||
13 | Polygonati rhizoma | Extract | SD rats | 1, 2 and 4Â g/kg | 14Â weeks | Resveratrol | 40Â mg/kg | [165] |
Extract | SD rats | 4Â g/kg | 14Â weeks | Simvastatin | 1.8Â mg/kg | [170] | ||
Polysaccharides | KunMing mice | 200, 400, and 800Â mg/kg | 14Â days | Simvastatin | 30Â mg/kg | [171] | ||
Polysaccharides | SD rats | 120, 240, 480Â mg/kg | 14Â weeks | Simvastatin | 1.8Â mg/kg | [172] | ||
Saponin | ICR mice | 1, 1.5, and 2Â g/kg | 4Â weeks | Metformin | 0.5Â g/kg | [173] | ||
Syringaresinol-di-o-β-d-glucoside | SPF mice | 25, 50 and 75 mg/kg | 2 weeks | / | / | [174] | ||
14 | Astragali radix | Total flavones | C57BL/6 J mice | 5, 25 and 50 mg/kg | 8 weeks | Metformin | 0.15 g/kg | [182] |
Total flavones | ApoE − / − mice | 10 and 20 mg/kg | 16 weeks | / | / | [183] | ||
Astragaloside IV | SD rats | 80Â mg/kg | 8Â weeks | Metformin | 200Â mg/kg | [186] | ||
15 | Puerariae radix | Extract | C5BL/6 mice | 100 and 300Â mg/kg | 16Â weeks | Metformin | 250Â mg/kg | [193] |
Puerarin | SD rats | 2Â g/kg | 16Â weeks | / | / | [194] | ||
Puerarin | SD rats | 100Â mg/kg | 8Â weeks | / | / | [195] | ||
Polysaccharides | db/db mice | 100 and 200Â mg/kg | 6Â weeks | Rosiglitazone | 10Â mg/kg | [187] | ||
PL-S2 | Wistar rats | 50Â mg/kg | 3Â weeks | Simvastatin | 8Â mg/kg | [196] | ||
16 | Cassiae semen | Extract | SD rats | 10Â g/kg | 4Â weeks | Atorvastatin | 10Â mg/kg | [201] |
Extract | SD rats | 54, 162 and 486Â mg/kg | 4Â weeks | Atorvastatin | 10Â mg/kg | [202] | ||
Total aglycones (TA), rubrofusarin-6-β-gentiobioside (RG) and aurantio-obtusin (AO) | C57BL/6 mice | TA 10 g/kg, RG 20 mg/kg, and AO 20 mg/kg | 3 weeks | / | / | [203] | ||
Extract | Wistar rats | 0.5, 1, and 2Â g/kg | 6Â weeks | Metformin | 0.2Â g/kg | [204] | ||
Anthraquinone glycoside | SD rats | 5, 10 and 20Â mg/kg | 6Â weeks | Polyene phosphatidylcholine | 23Â mg/kg | [206] | ||
1,8-Dihydroxyanthraquinone | mice | 5Â mg/kg | 6Â weeks | / | / | [207] | ||
17 | Canavaliae semen | Total terpenoids and total flavonoids | Wistar rats | 400Â mg/kg | 3Â weeks | Glibenclamide | 5Â mg/kg | [213] |
Protein extract | SD rats | 4 and 6Â g/200Â g | 2Â weeks | / | / | [215] | ||
18 | Lablab semen album | Extract | C57BL/6Â J mice | 25Â mg/kg | 9Â weeks | Milk thistle | 100Â mg/kg | [220] |
Extract | C57BL/6Â J mice | 25, 50 and 100Â mg/kg | 9Â weeks | Milk thistle | 100Â mg/kg | [221] | ||
19 | Persicae semen | Amygdalin | LDLR-/- mice | 1, 3 and 10Â mg/kg | 4Â weeks | / | / | [225] |
Amygdalin | ApoE-/- mice | 0.04 and 0.08Â mg/kg | 12Â weeks | Simvastatin | 2.57Â mg/kg | [226] | ||
Peach kernel oil | ApoE-/- mice | 2 and 5Â g/kg | 8Â weeks | Simvastatin | 5Â mg/kg | [228] | ||
20 | Portulacae Herba | Extract | Wistar rats | 400Â mg/kg | 4Â weeks | Atorvastatin | 10Â mg/kg | [235] |
Extract | Wistar rats | 10Â g/kg | 4Â weeks | / | / | [236] | ||
Extract | albino rats | 5% and 10% | 8Â weeks | / | / | [237] | ||
Extract | Wistar rats | 0.50% | 4Â weeks | / | / | [238] | ||
Extract | C57BL/6 mice | 5% and 10% | 12Â weeks | / | / | [239] |