Nitidine chloride induces caspase 3/GSDME-dependent pyroptosis by inhibting PI3K/Akt pathway in lung cancer

Chinese Medicine

Table 1 IC₅₀ of nitidine chloride or cisplatin on human bronchial epithelial normal cells and 11 lung cancer cells for 48 h

Cell lines		IC₅₀ (μmol/L)of DDP	IC₅₀ (μmol/L) of NC	SI (Selectivity index) of NC
Nomal lung cell	BEAS-2B	30.451 ± 1.083	2.366 ± 0.061	–
SCLC	NCI-H1688	16.933 ± 1.509	1.520 ± 0.076	1.56
	NCI-H446	16.724 ± 1.696	1.987 ± 0.208	1.2
	NCI-H209	35.021 ± 1.85	3.261 ± 0.093	0.75
	NCI-H196	16.217 ± 1.734	4.649 ± 0.571	0.51
LUSC	SK-MES-1	14.652 ± 1.442	6.703 ± 0.025	0.36
LUSC	NCI-H226	31.816 ± 0.513	3.813 ± 0.113	0.62
LUAD	A549	13.677 ± 0.511	0.706 ± 0.033	3.42
	NCI-HCC827	24.811 ± 2.3	3.053 ± 0.178	0.77
	NCI-H1299 NCI-H1975 PC9	27.207 ± 0.82 11.770 ± 0.398 11.876 ± 0.184	4.791 ± 1.042 5.072 ± 0.183 5.54 ± 0.547	0.6 0.47 0.44

ISSN: 1749-8546