Table 4 GRADE assessment for combined QFPD-WM vs WM treatment
Outcome | Certainty assessment | Summary findings | Evidence strength | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
Risk of bias | Inconsistency | Indirectness | Imprecision | Publication bias | No. of patients | Effect | ||||
[Intervention] | [Comparison] | Relative (95% CI) | Absolute (95% CI) | |||||||
Clinical effective rate | Serious | Not serious | Not serious | Not serious | None | 454/473 (96.0%) | 368/436 (84.4%) | RR 1.15 (1.10 to 1.20) | 127 more per 1000 (from 84 to 169 more) | ⨁⨁⨁◯ Moderate |
Lung CT | Serious | Not serious | Not serious | Not serious | Publication bias strongly suspected | 200/222 (90.1%) | 179/243 (73.7%) | RR 1.22 (1.12 to 1.33) | 162 more per 1000 (from 88 to 243 more) | ⨁⨁◯◯ Low |
Ranging from mild to critical | Serious | Not serious | Not serious | Not serious | None | 15/192 (7.8%) | 32/155 (20.6%) | RR 0.35 (0.21 to 0.60) | 134 fewer per 1000 (from 163 to 83 fewer) | ⨁⨁⨁◯ Moderate |
Time for nucleic acid conversion | Serious | Not serious | Not serious | Not serious | Publication bias strongly suspected | 248 | 254 | – | MD 4.08 lower (5.14 lower to 3.02 lower) | ⨁⨁◯◯ Low |
Adverse effect | Serious | Not serious | Not serious | Not serious | None | 207/1937 (10.7%) | 251/1928 (13.0%) | RR 0.80 (0.68 to 0.95) | 26 fewer per 1000 (from 42 to 7 fewer) | ⨁⨁⨁◯ Moderate |
Fever | Serious | Not serious | Not serious | Not serious | Publication bias strongly suspected | 97 | 78 | – | MD 1.48 lower (1.84 lower to 1.13 lower) | ⨁⨁◯◯ Low |
CRP | Serious | Not serious | Not serious | Not serious | None | 156 | 159 | – | MD 4.39 lower (6.58 lower to 2.2 lower) | ⨁⨁⨁◯ Moderate |