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Table 3 Inter- and intra-day precision and accuracy for the four analytes in dog plasma

From: Pharmacokinetic study of the main components of Tanreqing capsules and Tanreqing injections in beagles by liquid chromatography–tandem mass spectrometry

Analyte

Nominal concentration (ng/mL)

Intra-day (n = 5)

Inter-day (n = 5)

Measured

concentration

(mean ± SD, ng/mL)

Precision

(RSD%)

Accuracy

(RE%)

Measured concentration

(mean ± SD, ng/mL)

Precision

(RSD%)

Accuracy

(RE%)

Baicalin

2

2.00 ± 0.22

11.23

– 0.13

2.02 ± 0.20

9.71

0.78

4

4.04 ± 0.17

4.10

0.99

4.01 ± 0.30

7.57

0.23

20

18.77 ± 0.96

5.11

– 6.15

18.91 ± 1.21

6.42

– 5.44

200

211.08 ± 3.43

1.63

5.54

212.40 ± 7.49

3.53

6.20

Ursodeoxycholic acid

10

10.90 ± 0.54

4.93

8.96

10.68 ± 0.52

4.85

6.83

20

17.77 ± 0.38

2.13

– 11.17

17.46 ± 0.51

2.93

– 12.71

100

87.02 ± 1.19

1.37

– 12.98

86.00 ± 2.16

2.51

– 14.00

1000

1119.11 ± 26.08

2.33

11.91

1081.33 ± 53.16

4.92

8.13

Chenodeoxycholic acid

1

0.94 ± 0.04

4.10

– 5.63

0.99 ± 0.08

8.30

– 1.30

2

1.98 ± 0.05

2.39

– 1.23

2.06 ± 0.10

4.70

3.00

10

9.13 ± 0.36

3.98

– 8.71

9.74 ± 0.94

9.61

– 2.61

100

94.07 ± 3.89

4.14

– 5.93

97.31 ± 4.01

4.12

– 2.69

Chlorogenic acid

1

0.97 ± 0.08

8.75

– 3.17

1.01 ± 0.08

7.77

1.46

2

1.96 ± 0.15

7.77

– 2.07

2.11 ± 0.16

7.71

5.27

10

9.49 ± 0.73

7.70

– 5.09

9.50 ± 0.91

9.54

– 5.01

100

97.86 ± 1.82

1.86

– 2.14

100.09 ± 4.63

4.62

0.09

  1. RSD Relative standard deviation; RE Relative error