Pharmacokinetic study of the main components of Tanreqing capsules and Tanreqing injections in beagles by liquid chromatography–tandem mass spectrometry

Table 6 Pharmacokinetic parameters of Tanreqing analytes in dog plasma after a single dose of TRQI or TRQC

Analyte	Parameter	Units	TRQI (0.5 mL/kg)		TRQC (0.09 g/kg)
Analyte	Parameter	Units	Mean	SD	Mean	SD
Baicalin	t_1/2	h	6.75	1.75	4.97	2.44
	T_max	h	0.08	0.00	3.78	4.70
	C_max	μg/L	1050.12	322.31	4.79	4.01
Ursodeoxycholic acid	t_1/2	h	27.67	46.34	10.36	14.09
	T_max	h	0.08	0.00	5.94	8.91
	C_max	μg/L	2748.05	680.71	1332.75	801.89
Chenodeoxycholic acid	t_1/2	h	5.67	3.81	5.93	4.87
	T_max	h	1.07	2.42	7.53	9.16
	C_max	μg/L	119.97	84.34	99.81	84.43
Chlorogenic acid	t_1/2	h	0.89	0.30	1.45	0.39
	T_max	h	0.13	0.07	3.75	2.90
	C_max	μg/L	26.56	6.89	8.58	5.32

Samples were collected at 0, 5, 10, 15, 20, 30, and 45 min and then at 1, 2, 4, 6, 8, 12, and 24 h (a total of 14 time points) for TRQI, and 0, 10, 20, and 40 min and then at 1, 1.5, 2, 2.5, 3, 4, 6, 8, 12, and 24 h (a total of 14 time points) for TRIC

ISSN: 1749-8546