Pharmacokinetic study of the main components of Tanreqing capsules and Tanreqing injections in beagles by liquid chromatography–tandem mass spectrometry

Table 7 Pharmacokinetic parameters of four analytes in dog plasma after administration of TRQI or TRQC for 7 days

Analyte	Parameter	Units	TRQI (0.5 mL/kg)		TRQC (0.09 g/kg)
Analyte	Parameter	Units	Mean	SD	Mean	SD
Baicalin	t_1/2	h	5.54	6.48	12.13	12.71
	T_max	h	0.11	0.04	7.25	8.38
	C_max	μg/L	1365.78	934.82	12.21	8.22
Ursodeoxycholic acid	t_1/2	h	6.84	3.64	12.02	10.80
	T_max	h	1.72	2.62	5.69	4.20
	C_max	μg/L	5057.95	1592.37	3401.04	4312.06
Chenodeoxycholic acid	t_1/2	h	6.25	6.25	13.73	21.22
	T_max	h	1.72	2.62	4.72	4.29
	C_max	μg/L	967.63	1446.30	520.63	1065.46
Chlorogenic acid	t_1/2	h	0.88	0.31	1.56	1.04
	T_max	h	0.18	0.08	3.17	0.93
	C_max	μg/L	20.26	10.02	3.90	2.75

ISSN: 1749-8546