Pharmacokinetic study of the main components of Tanreqing capsules and Tanreqing injections in beagles by liquid chromatography–tandem mass spectrometry

Table 8 The area under the curve (μg/L × h) after a single administration of TRQI and TRQCs in beagles

Treatment	No	Baicalin		Ursodeoxycholic acid		Chenodeoxycholic acid		Chlorogenic acid
Treatment	No	AUC_0–24 h	AUC_t–∞	AUC_0–24 h	AUC_t–∞	AUC_0–24 h	AUC_t–∞	AUC_0–24 h	AUC_t–∞
TRQI (0.5 mL/kg)	1	44.51	57.67	18,217.56	18,383.85	1489.58	1513.91	29.65	30.35
	2	18.71	22.93	1101.92	1252.37	107.59	115.70	17.84	17.94
	3	0.47	0.07	2123.02	2129.29	238.29	238.42	23.30	23.38
	4	161.26	209.23	898.25	2922.46	89.03	143.43	11.17	12.10
	5	1.98	2.22	1164.19	1213.58	136.52	148.59	15.19	15.79
	6	39.93	54.11	992.23	1154.72	95.00	459.97	24.75	25.17
	Mean	44.40	57.71	4082.86	4509.38	359.34	436.67	20.32	20.79
TRQCs (0.09 g/kg)	1	16.04	17.28	1697.27	5384.48	104.10	212.35	21.05	93.50
	2	36.36	37.47	3189.09	3203.15	257.10	282.25	48.11	49.75
	3	11.82	16.12	4593.89	4594.24	421.35	421.42	33.19	36.26
	4	15.63	18.98	11,340.92	11,382.50	1330.27	1342.98	13.88	15.05
	5	1.15	1.19	1878.70	2503.16	126.03	147.57	-	-
	6	3.38	6.29	3702.57	4651.95	1077.47	80,865.10	-	-
	Mean	14.06	16.22	4400.40	5286.58	552.72	13,878.61	29.06	48.64
	t-Test	0.25	0.23	0.92	0.81	0.55	0.34	0.24	0.07

ISSN: 1749-8546