Pharmacokinetic study of the main components of Tanreqing capsules and Tanreqing injections in beagles by liquid chromatography–tandem mass spectrometry

Table 9 The area under the curve (μg/L × h) after administration of TRQIs and TRQCs for 7 days in beagles

Treatment	No.	Baicalin		Ursodeoxycholic acid		Chenodeoxycholic acid		Chlorogenic acid
Treatment	No.	AUC_0–24 h	AUC _0–∞	AUC_0–24 h	AUC _0–∞	AUC_0–24 h	AUC _0–∞	AUC_0–24 h	AUC _0–∞
TRQI (0.5 mL/kg)	1	42.58	45.80	72,412.00	75,937.53	20,011.58	20,024.24	6.07	6.07
	2	369.81	533.81	1724.64	1859.36	120.94	183.39	5.24	5.59
	3	36.82	37.57	14,481.26	14,570.64	3241.10	3247.35	8.21	9.20
	4	527.34	669.59	4739.93	14,924.76	669.04	6190.14	19.08	19.29
	5	526.36	710.56	2560.78	4218.73	233.88	398.78	23.93	24.39
	6	865.34	1288.38	2665.15	2807.50	137.54	137.95	29.99	30.67
	Mean	394.71	547.62	16,430.63	19,053.09	4069.01	5030.31	15.42	15.87
TRQC (0.09 g/kg)	1	79.61	80.46	2762.49	2943.40	194.76	230.66	0.72	1.31
	2	149.00	164.07	23,894.62	24,369.21	1901.65	1928.12	3.19	3.20
	3	69.70	74.32	7185.97	7521.86	493.02	537.95	5.21	5.62
	4	68.04	88.26	109,038.51	112,128.46	16,729.10	16,833.54	22.55	23.20
	5	244.79	398.22	10,518.51	20,052.83	500.02	1963.93	11.37	13.34
	6	32.55	44.30	17,555.90	45,005.59	759.90	760.82	26.93	26.96
	Mean	107.27	141.61	28,492.67	35,336.89	3429.74	3709.17	11.66	12.27
	t-Test	0.06	0.07	0.56	0.44	0.88	0.75	0.55	0.57

ISSN: 1749-8546