Table 2 Pharmacological effect of Nauclea officinalis and its different extracts in vivo and in vitro
NO | Compound Name | Cells/ Virus/Bacterials | Animal model | Dose/concentration | Results |
|---|---|---|---|---|---|
1 | Naucleoffieine H [31] | RAW264.7 | / | 3, 10, 30 μM | Reduced productions of NO, iNOS and TNF-α |
2 | Monoterpene indole alkaloids [37] | RAW264.7, HIV-1 | / | 0.0625, 0.32, 1.6, 8, 40 μM | Reduced productions of NO, inhibited the activity of HIV-1 |
3 | Nauclea officinalis [50] | RAW264.7 | / | 10, 20, 50, 100 µg/mL | Reduced mRNA expressions and productions of NO, TNF-α, IL-6 and IL-1β; Suppressed p-IκBα and p-p65 |
4 | Strictosamide [29] | RAW264.7 | / | 0, 25, 50, 100, 200 µM | Suppressed productions of NO, iNOS, TNF-α and IL-1β; Reduced expressions of p-p65, p-IκBα, p-IKKα, p-p38, p-ERK and p-JNK |
5 | Strictosamide [14] | / | ICR mice | 20, 40Â mg/kg | Reduced ear edema in mice induced by TPA; Reduced peritoneal vascular permeability in mice stimulated by acetic acid; Reduced leukocyte count in the peritoneal cavity of mice after CMC-Na treatment; Prolonged the pain latency and decreased the writhing counts |
6 | Extracts of Nauclea officinalis Pierre ex Pitard [60] | / | Balb/c mice, ovalbumin induced asthma model | 1, 2, 4Â mg/kg | Reduced the number of inflammatory cells in mouse BALF; Affected the secretion of cytokines in mouse BALF |
7 | Extracts of Nauclea officinalis Pierre ex Pitard leaf [57] | / | ICR mice | 0.390, 0.195, 0.098Â g/kg/days | Prolonged pain latency; Reduced the number of twisting reactions and antagonized the increased intra-abdominal capillary permeability in mice caused by acetic acid; Reduced xylene-induced swelling of the pinna in mice |
8 | Strictosamide [63] | IEC6/HT-29 | / | 100, 200 μM | Reduced disease activity index and reduced H&E damage in DSS model mice; Reduced the expression of p-IκBα, p-p65; Downregulated expressions of TNF-α, IL-1β, IL-6, MPO and iNOS |
/ | Male Balb/c mice, dextran sulfate sodium (DSS) induced ulcerative colitis model | 20, 40Â mg/kg | |||
9 | Extracts of Nauclea officinalis Pierre ex Pitard [67] | Staphylococcus aureus | / | 0.3125, 0.625, 1.25, 2.5, 5, 10, 20, 40, 80, 160, 320 mg/kg | Had an efficient inhibitory effect on Staphylococcus aureus |