Fig. 4

CRD reduces Aβ plaque formation in the hippocampus, but the Tau phosphorylation levels in the brain do not change. Immunofluorescent staining of Aβ plaques in the hippocampus (A). Scale bar, 100 μm. Cumulative optical density (IOD) of Aβ plaques in the hippocampus (C), each group n = 4. Representative blots of the hippocampus of 3 × Tg-AD mice administered CRD or saline solution were analyzed by immunoblotting (B). Quantification of data from the upper panel (n = 4 mice) (D). Data are expressed as the mean ± SD from 4 mice per group. ^#p < 0.05, ^##p < 0.01 compared with the WT group. *p < 0.05, **p < 0.01 versus the 3 × Tg-AD group