Fig. 4

Anti-ACV resistant strains activity of Fr.8.3. A real-time fluorescence quantitative amplification reactions (Q-PCR) assessing the DNA level of the HSV-1 drug-resistant strain HSV-1/Blue, B viral titers of HSV-1/Blue, C real-time fluorescence quantitative amplification reactions (Q-PCR) assessing the DNA level of the HSV-1 drug-resistant strain HSV-1/153, D viral titers of HSV-1/153. The results presented were obtained from three independent experiments. Data represent the mean ± SD. Statistical differences were analyzed via Student’s t test, and a value of p ≤ 0.05 was considered significant (^*p ≤ 0.05, ^**p ≤ 0.01, ^***p ≤ 0.001)