From: Advances in natural product anti-coronavirus research (2002-2022)
Name of formula | Main component drugs | Main mechanisms | References |
---|---|---|---|
Yupingfeng Powder | Astragalus Membranaceus, Atractylodis Macrocephalae Rhizoma | Reduces TNF- α and IL-6 levels, inhibits phosphorylation and chemotaxis of JAK1/STAT3 pathway, thereby reducing IL-8 production, and regulates MMP-9/TIMP1 homeostasis, thereby inhibiting airway inflammatory response and airway remodeling | |
Maxing Shigan Decoction | Ephedra Herba, Armeniacae Semen, Gypsum Fibrosum, Glycyrrhizae Radix | Reduces the inflammatory response and modulates the immune system by regulating several proteins that interact with ACE2 and several signaling pathways associated with disease development | [46] |
Xiaochaihu Decoction | Bupleuri Radix, Scutellariae Radix, Pinelliae Rhizoma, Glycyrrhizae Radix | Immobilizes ACE2 and prevents the virus from binding to ACE2 to achieve antiviral effect | |
Yinqiao Powder | Lonicera Japonica, Fructus Forsythiae, Platycodon Grandiflorum | Exerts anti-inflammatory effect through mediating NF-κB signaling pathway, B-cell signaling pathway and T-cell signaling pathway | [48] |
Sangju Drink | Folium Mori, Flos Chrysanthemi, Armeniacae Semen | Exerts anti-inflammatory effect through mediating NF-κB signaling pathway, B-cell signaling pathway and T-cell signaling pathway | [48] |
Dayuan Drink | Areca Catechu, Magnolia Officinalis, Amomum Tsao-ko | Acts on PIK3CG, AKT1, IL-4, IL-6, IL-7 and other targets to reduce oxidative stress and achieve anti-inflammatory and immunomodulatory effects | [27] |
Xuanbai Chengqi Decoction | Gypsum Fibrosum, Rheum Officinale, Armeniacae Semen | Reduces TNF-α and IL-1β levels and improves IL-10, thereby reducing the inflammatory response | [17] |
Maxing Yigan Decoction | Ephedra, Armeniacae Semen, Pearl Barley, Glycyrrhizae Radix | Influences AGE-RAGE, IL-17, tumor necrosis factor (TNF) and other signaling pathways through IL-6 to achieve anti-inflammatory and anti-viral effects | [49] |
Tingli Dazao Xiefei Decoction | Draba Nemorosa, Fructus Ziziphi Jujubae | Decreases serum levels of IL-6 and TGF-β1, increases IL-10 levels, suppresses inflammatory responses and improves histopathological changes in the lung | [50] |
Qianjin Weijing Decoction | Rhizoma Phragmitis, Pearl Barley, Seed of Chinese Waxgourd, Peach Kernel | Reduces the level of inflammatory factors such as IL-6, inhibits the release of inflammatory factors from helper T cells, and promotes the release of anti-inflammatory factors from regulatory T cells to achieve anti-inflammatory effects | [17] |
Prevention of “COVID-19” No. 2 formula | Astragalus Membranaceus, Lonicera Japonica, Citri Pericarpium, Fructus Ziziphi Jujubae, Glycyrrhizae Radix | Exert immunomodulatory effects on CsA-induced immunodeficiency mouse model by improving thymic tissue structure and regulating the expression levels of IFN-γ and Ang II | [43] |