Table 2 Semi-quantitative statistics for the differential metabolites regulated by CF and four fractions

Deoxyuridine

Plasma

0.5↓^**

1.3↑

1.2↑

1.2↑

1.3↑

2.1↑^**

1.2↑

c

Deoxycytidine

Plasma

0.6↓^**

1.2↑

1.1↑

1↑

1.1↑

1↑

1.2↑

c

Adenosine monophosphate

Plasma

1.9↑^*

0.6↓^*

0.7↓

0.8↓

0.5↓^*

0.7↓

0.7↓

a

Adenosine

Plasma

2.6↑^*

0.6↓

1.9↑

0.8↓

0.8↓

0.8↓

1.6↑

a

Cytidine

Plasma

0.6↓^*

1.1↑

1.3↑^*

1↓

1↓

1.2↑

1.2↑

c

L-Tyrosine

Plasma

0.6↓^**

1↑

1↓

1.1↑

0.9↓

0.9↓

1↓

d

L-Serine

Plasma

0.6↓^**

1↑

1.1↑

1.3↑^**

0.9↓

1.1↑

1↑

d

alpha-Ketoglutaric acid

Plasma

0.5↓^**

1.8↑^**

1.7↑^**

1.8↑^*

1.4↑

1.7↑^*

0.8↓

b

Ornithine

Plasma

0.6↓^*

1↑

1↓

1.2↑

0.9↓

1↓

1↑

b,e

Orotic acid

Plasma

5.3↑^**

0.9↓

1.1↑

1.1↑

1↓

0.8↓

0.8↓^*

c

Riboflavin

Plasma

1.5↑^**

0.8↓^*

0.8↓^*

0.9↓

0.7↓^**

0.8↓^*

0.8↓

f

Uric acid

Plasma

4.3↑^**

0.8↓^*

1↑

1.1↑

0.7↓^**

0.6↓^*

0.2↓^**

a

Urea

Plasma

1.3↑^*

0.8↓

0.9↓

1.1↑

0.9↓

1.1↑

1↓

a,b

Xanthosine

Plasma

0.5↓^**

1.2↑

0.9↓

1.1↑

1.1↑

1.4↑

3.1↑^**

a

Uracil

Plasma

5↑^**

0.9↓

0.9↓

1.2↑

0.7↓

0.8↓

0.6↓^*

c

N-Acetyl-L-phenylalanine

Plasma

2.3↑^*

0.7↓

0.7↓

0.4↓^*

0.7↓

0.7↓

1.3↑

L-Arginine

Plasma

0.6↓^**

1↓

1↓

1.2↑

0.9↓

1↓

1↓

b,d,e

L-Glutamine

Plasma

0.6↓^**

1.1↑

1.2↑

1.2↑^*

1.1↑

1.1↑

1.1↑

a,b,c,d,g

Indoxyl sulfate

Plasma

2.8↑^**

0.7↓

0.7↓

0.9↓

0.6↓^*

0.7↓

0.8↓

Kynurenic acid

Plasma

1.8↑^*

0.7↓

0.8↓

0.8↓

0.5↓^**

0.9↓

0.6↓^*

Indoleacetaldehyde

Plasma

0.6↓^*

0.8↓

1.2↑

0.9↓

1.2↑

1.3↑

1.3↑

Guanosine monophosphate

Plasma

1.7↑^*

0.5↓^*

0.6↓

0.7↓

0.5↓^*

0.7↓

1↓

a

Phosphocreatine

Plasma

0.6↓^*

1.3↑

1.1↑

1.5↑

0.9↓

1↓

0.9↓

e, g

Indoxyl glucuronide

Plasma

2.1↑^*

0.6↓^*

0.6↓^*

1.1↑

0.6↓^*

0.8↓

0.7↓

i

N-Acetylhistidine

Plasma

1.6↑^**

0.8↓

0.8↓

0.8↓

0.7↓^**

0.8↓

0.8↓

Deoxycytidine

Kidney

0.6↓^**

1↑

1↑

0.8↓

1↓

1↓

1.3↑

c

Carnosine

Kidney

0.5↓^*

1.7↑^*

1.5↑^**

1.8↑^**

1.6↑^*

1.3↑

1.2↑

h

β-Alanine

Kidney

0.6↓^**

1.5↑^*

1.3↑

1.7↑^*

1.3↑

1.3↑

1.2↑

c,h

SN-glycero-3-phosphocholine

Kidney

0.4↓^*

3.1↑^**

2.3↑^**

2.4↑^*

3.6↑^**

2.2↑^*

1.3↑

Hypoxanthine

Kidney

0.6↓^**

1.8↑^**

1.5↑^*

1.6↑^*

1.5↑^**

1↑

1.5↑^*

a

Inosine 5ʹ- monophosphate

Kidney

0.6↓^*

2.6↑^*

1.8↑

2.4↑

2.7↑^**

1.3↑

1.3↑

a

Inosine

Kidney

0.5↓^**

2↑^**

1.7↑^*

1.9↑^**

1.7↑^**

1.1↑

2.1↑^**

a

Orotic acid

Kidney

6.4↑^**

1.2↑

0.9↓

1.6↑^*

1.3↑

0.8↓

0.7↓

c

Succinic acid

Kidney

1.4↑^*

0.9↓

0.8↓

0.8↓

0.8↓^*

0.8↓^*

0.8↓

Uridine

Kidney

0.6↓^**

1.5↑^**

1.4↑

1.3↑^*

1.4↑^*

1↑

1.2↑

c

Adenosine 5ʹ-triphosphate

Kidney

0.6↓^**

1.5↑^*

1.1↑

1.4↑^*

1.6↑^*

1.2↑

1↓

a

Cytosine

Kidney

0.7↓^**

1.1↑

1.1↑

0.9↓

1↑

0.9↓

1.1↑

c

L-Glutamine

Kidney

0.7↓^*

1.1↑

1↑

0.9↓

1↑

1.2↑

1↑

a, c,  e

Citrulline

Kidney

1.4↑^*

0.7↓^*

0.7↓^**

0.8↓

0.6↓^**

0.8↓

0.8↓

e

Betaine-Aldehyde

Kidney

2.4↑^**

0.4↓^**

0.7↓

0.4↓^**

0.4↓^**

0.8↓

0.4↓^**

Ribose 5-phosphate

Kidney

0.5↓^**

2.1↑^**

1.7↑

2.1↑^**

1.8↑^**

1.2↑

1.5↑^*

a

CDP-ethanolamine

Kidney

0.5↓^*

2.3↑^**

1.4↑

1.9↑^*

2.3↑^*

1.6↑

1↑

Phosphorylcholine

Kidney

0.4↓^*

2.7↑^**

2.4↑^**

2.4↑^*

3.5↑^**

2.1↑^*

1.3↑