Fig. 7

The effect of KXS-containing serum in morphological changes, mitochondrial fission and fusion-related proteins, neurotrophic factors and synaptic-related proteins and SIRT3/NLRP3 pathway in HT22 cells. A Morphological changes in HT22 cells treated with Aβ and KXS-containing serum. B Expression of Mfn1, Mfn2, p-Drp1 and Drp1; C–E Histogram of relative expression of Mfn1, Mfn2, p-Drp1/Drp1; F Expression of BDNF, NGF, SYN and PSD95; G–J Histogram of relative expression of BDNF, NGF, SYN and PSD95. K Expression of SIRT3 and NLRP3 inflammasome-related proteins; B Histogram of relative expression of SIRT3 proteins; L–Q Histogram of relative expression of NLRP3 inflammasome-related proteins. KXS-H: 10 g/kg/day. The experiment data are expressed as means ± SEM. n = 3 in each group. ^#P < 0.05, ^##P < 0.01, ^###P < 0.001 vs. Ctrl group; *P < 0.05, **P < 0.01, ***P < 0.001 vs. APP/PS1 group