Pharmacological activity | Experimental study | Tested extract of Paeonia emodi Wall. ex Royle | IC50/dose | Main results | Refs. |
---|---|---|---|---|---|
Antibacterial | In vitro Escherichia coli Proteus aeruginosa Staphylococcus aureus Staphylococcus epidermidis Salmonella typhi Proteus vulgaris Klebsiella pneumoniae | n-hexane chloroform Ethyl acetate Ethanolic silveroxide | NA | ↓ Bacterial growth | [49] [39] [35] |
Antifungal | In vitro Pseudalleschena boydii Trichophyton schoenleinii Candida albicans Aspergilus niger Trichophyton simii Macrophomina phaseolina | Ethanolic Methanolic | IC50 = 400 µg/mL IC50 = 100–900 µg/mL | Moderate antifungal activity | |
Neuroprotective | In vivo Mice PTZ epilepsy model | Roots ethanolic extract | Dose = 300–600 mg/kg/bw | ↑Memory ↓Brain oxidative damage ↓Anxiety ↓Seizures | [4] |
Enzymes inhibition | In vitro | Fruit ethanolic extract | IC50 = 147.5–498.2 µM | ↓Lipoxygenase | [8] |
Roots ethanolic extract | IC50 = 1.88 mM | ↓β-glucuronidase | [96] | ||
Antispasmodic | In vivo Rabbits | Crude extract | Dose = 5 mg/mL/kg/bw | ↓Smooth muscle spasms | [48] |
Anti-inflammatory | In vivo Albino rats | Roots aqueous extract | Dose = 20 g/5 h | ↓Pro-inflammatory factors | [4] |
Hepatoprotective | In vivo Albino rats | NA/ethanol | Dose = NA/1 day | Hepatoprotective against ethanolic and methanolic toxicity | |
Nephroprotective | In vivo Wistar rats | Roots/alcoholic/ Hydroalcholic extract | Dose = 100,200, 400 mg/kg/45 days | Protective effects against kidney damages |