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Table 4 The main pharmacological properties of P.emodi

From: A comprehensive review on traditional uses, phytochemistry and pharmacological properties of Paeonia emodi Wall. ex Royle: current landscape and future perspectives

Pharmacological activity

Experimental study

Tested extract of Paeonia emodi Wall. ex Royle

IC50/dose

Main results

Refs.

Antibacterial

In vitro

Escherichia coli

Proteus aeruginosa

Staphylococcus aureus

Staphylococcus epidermidis

Salmonella typhi

Proteus vulgaris

Klebsiella pneumoniae

n-hexane

chloroform

Ethyl acetate

Ethanolic silveroxide

NA

↓ Bacterial growth

[49]

[39]

[35]

Antifungal

In vitro

Pseudalleschena boydii

Trichophyton schoenleinii

Candida albicans

Aspergilus niger

Trichophyton simii

Macrophomina phaseolina

Ethanolic

Methanolic

IC50 = 400 µg/mL

IC50 = 100–900 µg/mL

Moderate antifungal activity

[5, 24]

Neuroprotective

In vivo

Mice

PTZ epilepsy model

Roots ethanolic extract

Dose = 300–600 mg/kg/bw

↑Memory

↓Brain oxidative damage

↓Anxiety

↓Seizures

[4]

Enzymes

inhibition

In vitro

Fruit ethanolic extract

IC50 = 147.5–498.2 µM

↓Lipoxygenase

[8]

Roots ethanolic extract

IC50 = 1.88 mM

↓β-glucuronidase

[96]

Antispasmodic

In vivo

Rabbits

Crude extract

Dose = 5 mg/mL/kg/bw

↓Smooth muscle spasms

[48]

Anti-inflammatory

In vivo

Albino rats

Roots aqueous extract

Dose = 20 g/5 h

↓Pro-inflammatory factors

[4]

Hepatoprotective

In vivo

Albino rats

NA/ethanol

Dose = NA/1 day

Hepatoprotective against ethanolic and methanolic toxicity

Nephroprotective

In vivo

Wistar rats

Roots/alcoholic/

Hydroalcholic extract

Dose = 100,200, 400 mg/kg/45 days

Protective effects against kidney damages

  1. Symbols and abbreviations: ↑ increase, ↓decrease, the half maximal inhibitory concentration (IC50), Body Weight. (bw), Pentylenetetrazole (PTZ), nonavailable (NA)