From: Therapy of traumatic brain injury by modern agents and traditional Chinese medicine
Traditional Cinese medicines | Models | Species | Gender | Sample size | Mode of action | Effects on post‐TBI consequences |
---|---|---|---|---|---|---|
CCI | Mouse | Male | Unknown | ↓ p-AMPKα, PGC-1α, ERRα, cytochrome c and MTCO2, O2 and ATP; ↑HO-1 | ↑ neurovascular function | |
CCI | Mouse | Male | Unknown | ↑HO-1, Nrf2, Tom20 and PGC-1α; ↑Nampt, SIRT1, SIRT2, and SIRT3 | ↑ activity of astrocytes and neural stem cells | |
WDI | Rat | Male | 36 | ↓ p62,Beclin1, autophagy, light chain-3 protein | ↓ apoptosis cells | |
WDI | Rat | Male | 48 | ↓ p-p65, t-PA, PT, APTT and ET; ↑ t-PA/PAI-1, CD61, CD62 | ↓ intracranial hemorrhage | |
Gastrodia elata [74] | CCI | Rat | Female | Unknown | ↓ astrocytes, TNF-α and IL-6 | ↓ inflammation |
Rheum palmatum [77] | CCI | Rat | Male | 80 | ↓ MMP-9, ROS and p-ERK; ↑ ZO-1 | ↓ brain edema |
Ginkgo biloba [81] | WDI | Rat | Male | 80 | ↓ MMP-2 and MMP-9 | ↓ brain edema |
Curcuma longa/Polygonum cuspidatum/Salvia miltiorrhiza | – | – | – | – | – | – |
WDI | Rat | Male | 72 | ↓ CD8 T cells, no affecting the expressions of IL-2 and CD4 cells | ↑ immune-promoting, anti- inflammatory | |
CCI | Rat | Male | 88 | ↓ IL-6,↑IL-10, CD3 and CD4 T lymphocytes, blood monocyte | ↓ lesion volume, regulate cognitive and behavior function |