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Fig. 5 | Chinese Medicine

Fig. 5

From: Therapeutic mechanisms of the medicine and food homology formula Xiao-Ke-Yin on glucolipid metabolic dysfunction revealed by transcriptomics, metabolomics and microbiomics in mice

Fig. 5

Effect of XKY treatment on gut microbiome composition and intestinal tissue in db/db mice. A PCA on OTU level of the NC, MOD and XKY-H groups. B PCoA of an unweighted UniFrac distance matrix on OTU level in the NC, Model and XKY-H groups. C Hierarchical clustering of an unweighted UniFrac distance matrix on OTU level in the NC, Model and XKY-H groups. Taxonomic composition of gut microbiome in the rats at the class (D), family (E), and genus (F) levels. G Pearson’s correlation analysis between the metabolic related parameters and the key differential gut microbiota. H and I H&E staining and Immunohistochemistry analysis of intestinal tissue specimens in the NC, MOD and XKY-H groups. Representative images were presented. Scale bars represent 100 μm. J The mRNA expression of Claudin-1 and ZO-1 of intestinal in NC, MOD and XKY-H groups detected by RT-qPCR (K) and L Western blotting analysis of Claudin-1 and ZO-1 of intestinal in NC, MOD and XKY-H groups. Data were shown as means ± SD (n = 3–6, *P < 0.05, **P < 0.01, ***P < 0.001 vs. the Model group)

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