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Table 5 Traditional Chinese formulas information of included RCTs

From: Systematic analysis of randomised controlled trials of Chinese herb medicine for non-alcoholic steatohepatitis (NASH): implications for future drug development and trial design

No

Formula name

Composition (Latin name)

Action

Formula resources

References

1

Er Chen decoction

Pinelliae Rhizoma, Poria, Citri Exocarpium Rubrum, Glycyrrhizae Radix Et Rhizoma

Removing dampness, resolving phlegm and regulating the spleen and stomach

“Prescriptions of the Bureau of Taiping People’s Welfare Pharmacy”(太平惠民和劑局方)

Wang et al.* [124]

(二陳湯)

燥濕化痰, 理氣和中

Chen et al.* [74]

2

Bu Bi Wei Xie Yin Huo Sheng Yang Decoction*

Bupleuri Radix, Glycyrrhizae Radix Et Rhizoma Praeparata Cum Melle, Astragali Radix, Atractylodis Rhizoma, Notopterygii Rhizoma Et Radix, Cimicifugae Rhizoma, Ginseng Radix Et Rhizoma, Coptidis Rhizoma, Gypsum Fibrosum

Regulating the spleen and stomach, purging the pathogenic fire

“Treatise on the Spleen and Stomach”(脾胃論)

Wang et al.* [118]

(補脾胃瀉陰火升陽湯)

補脾升陽瀉火

3

Yin Chen Hao Decoction

Artemisiae Scopariae Herba, Gardeniae Fructus, Rhei Radix Et

Clearing heat, promoting dampness, and removing jaundice

“Treatise on Exogenous Febrile Disease”(傷寒論)

Chen et al.* [73]

(茵陳蒿湯)

Rhizoma

清熱, 利濕, 退黃

Tang et al.* [65]

Liu et al. [56]

Lin et al.* [47]

Lan et al.* [38]

4

Huang Lian Jie Du decoction

Coptidis Rhizoma, Scutellariae Radix, Phellodendri Chinensis

Clearing away heat and reducing fire

“Prescriptions for Emerent Reference”(肘後備急方)

Liu et al. [49]

(黃連解毒湯)

Cortex, Gardeniae Fructus

清熱瀉火

Wang et al. [26]

5

Sheng Jiang decoction

Codonopsis Radix, Astragali Radix, Atractylodis

Regulates the liver and spleen and promotes digestion

“Yi Xue Zhong Zhong Can Xi Lu”

Feng et al. [77]

(升降湯)

Macrocephalae Rhizoma, Citri Reticulatae Pericarpium, Magnoliae Officinalis Cortex, Galli Gigerii Endothelium Coreneum, Anemarrhenae Rhizoma, Paeoniae Radix Alba, Cinnamomi Ramulus, Chuanxiong Rhizoma, Zingiberis Rhizoma Recens

調節肝脾, 促進消化

(醫學衷中參西錄)

Zou et al. [42]

6

Four Gentlemen Decoction

Ginseng Radix Et Rhizoma, Atractylodis Macrocephalae Rhizoma, Poria, Glycyrrhizae Radix Et Rhizoma

Relieving fatigue and strengthening the spleen

“Prescriptions of the Bureau of Taiping People’s Welfare Pharmacy”(太平惠民和劑局方)

Chen et al. [74]

(四君子湯)

益氣健脾

7

Yi Guan Decoction

Glehniae Radix, Ophiopogonis Radix, Angelicae Sinensis Radix, Rehmanniae Radix, Lycii Fructus, Toosendan Fructus

Regulate liver function

“Xu Mingyi Lei ‘an”(續名醫類案)

Chen et al. [74]

(一貫煎)

滋陰疏肝

8

Xiao Jian Zhong Decoction

Cinnamomi Ramulus, Glycyrrhizae Radix Et Rhizoma Praeparata Cum Melle, Jujubae Fructus, Paeoniae Radix Alba, Zingiberis Rhizoma Recens, Maltose

Warming the middle and tonifying the deficient, harmonising the inner

“Treatise on Exogenous Febrile Disease”(傷寒論)

Chen et al. [74]

(小建中湯)

溫中補虛, 和裡緩急

9

Ge Xia Zhu Yu Decoction

Angelicae Sinensis Radix, Persicae Semen, Glycyrrhizae Radix Et Rhizoma, Carthami Flos, Wu Ling Zhi, Chuanxiong Rhizoma, Moutan Cortex, Paeoniae Radix Rubra, Linderae Radix, Corydalis Rhizoma, Cyperi Rhizoma, Aurantii Fructus

Promoting blood circulation and eliminating blood stasis, breaking down symptoms and eliminating nodules

“Corrections on the Errors of Medical Works”

Chen et al. [74]

(膈下逐瘀湯)

活血逐瘀, 破症消結

(醫林改錯)卷上

10

Wu Mei Pill

Mume Fructus, Asari Radix Et Rhizoma, Zingiberis Rhizoma, Coptidis Rhizoma, Aconiti Lateralis Radix Praeparata, Angelicae Sinensis Radix, Zanthoxyli Pericarpium, Cinnamomi Ramulus, Phellodendri Chinensis Cortex, Ginseng Radix Et Rhizoma

Promoting vitality, promoting correctness, eliminating fat and removing phlegm

“Treatise on Exogenous Febrile Disease”(傷寒論)

Zhang et al.* [72]

(烏梅丸)

益氣扶正, 消脂去痰

11

Jia Wei Bao He Pill

Atractylodis Macrocephalae Rhizoma, Poria, Citri Reticulatae Pericarpium, Magnoliae Officinalis Cortex, Aurantii Fructus Immaturus, Aurantii Fructus, Cyperi Rhizoma, Massa Medicata Fermentata, Hordei Fructus Germinatus, Pinelliae Rhizoma Praeparatum

Promoting blood circulation and eliminating blood stasis, breaking down symptoms and eliminating nodules

“Shoushibao Yuan”

Tian et al.* [66]

(加味保和丸)

活血逐瘀, 破症消結

(壽世保元)

12

Shen Ling Bai Zhu Powder

Nelumbinis Semen, Coicis Semen, Amomi Fructus, Platycodonis Radix, Lablab Semen Album, Poria, Ginseng Radix Et Rhizoma, Glycyrrhizae Radix Et Rhizoma Praeparata Cum Melle, Atractylodis Macrocephalae Rhizoma, Dioscoreae Rhizoma

Benefiting vital energy, strengthening the spleen, penetrating dampness and stopping diarrhea

“Prescriptions of the Bureau of Taiping People’s Welfare Pharmacy”(太平惠民和劑局方)

Dai et al. [52]

(參苓白術散)

益氣健脾, 滲濕止瀉

13

Bao He Pill

Crataegi Fructus, Massa Medicata Fermentata, Pinelliae Rhizoma, Poria, Citri Reticulatae Pericarpium, Raphani Semen, Forsythiae Fructus

Promotes digestion, dissolves phlegm, dispels fatigue and breaks stagnation

“Danxi’s Mastery of Medicine”(丹溪心法)

Zhan et al.* [97]

(保和丸)

消食和胃, 化痰祛疲破滯

14

Chai Shao Liu Jun Zi Decoction

Codonopsis Radix, Atractylodis Macrocephalae Rhizoma, Poria, Glycyrrhizae Radix Et Rhizoma, Paeoniae Radix Alba, Bupleuri Radix, Ramulus Uncariae Sinensis Cum, Pinelliae Rhizoma, Citri Reticulatae Pericarpium

Strengthening the spleen and calming the liver, resolving phlegm and dispelling wind

“Golden Mirror of Medicine” (醫宗金鑒)卷五十一

Liu et al.* [32]

(柴勺六君子湯)

健脾平肝, 化痰祛風

15

Ge Gen Qin Lian Decoction

Puerariae Lobatae Radix, Scutellariae Radix, Coptidis Rhizoma, Glycyrrhizae Radix Et Rhizoma

Removal of external symptoms and regulation of internal functions

“Treatise on Exogenous Febrile Disease”(傷寒論)

Zhang et al.* [34]

(葛根芩連湯)

解表清裡

16

Chaihu Shu Gan Powder

Citri Reticulatae Pericarpium, Bupleuri Radix, Chuanxiong Rhizoma, Cyperi Rhizoma, Aurantii Fructus, Paeoniae Radix Alba, Glycyrrhizae Radix Et Rhizoma

Diversifying the liver, promoting blood circulation and relieving pain

“Yi Xue Tong Zhi”(醫學統旨)

Lei et al.* [31]

(柴胡舒肝散)

疏肝理氣, 活血止痛

17

Chai Hu Yin Chen Wu Ling Powder

Bupleuri Radix, Artemisiae Scopariae Herba, Plantaginis Seme, Akebiae Caulis, Polyporus, Cinnamomi Cortex, Poria, Alismatis Rhizoma, Atractylodis Macrocephalae Rhizoma

Lowering fire, removing blood stasis and eliminating fat, strengthening the spleen, promoting dampness and activating blood circulation

“Jing Yue Quan Shu”(景嶽全書)

Long et al.* [23]

(柴胡茵陳五苓散)

降火祛瘀消脂, 健脾利濕活血

18

Ling Gui Zhu Gan decoction (苓桂術甘湯)

Cinnamomi Ramulus, Atractylodis Macrocephalae Rhizoma, Glycyrrhizae Radix Et Rhizoma Praeparata Cum Melle, Poria

Warming Yang and Removing Dampness溫陽化飲, 健脾利濕

"Synopsis of the Golden Chamber" (金匱要略)

Wu et al.* [51]

  1. *These RCTs adjusted the herbal composition of the formula based on the classical formula, i.e.…, increased or decreased the type or dosage of herbs