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Fig. 1 | Chinese Medicine

Fig. 1

From: Tanshinone IIA inhibits osteoclastogenesis in rheumatoid arthritis via LDHC-regulated ROS generation

Fig. 1

The effect of Tan IIA on the severity of RA in AIA rats. A The design of the animal experiment. B Representative photographs of arthritis symptoms in rat hind paws. C The assessment of paw swelling (data are mean ± SD, n = 6, ##P < 0.01, ###P < 0.001 vs. Control; *P < 0.05, **P < 0.01, ***P < 0.001 vs. Model). D Evaluation of clinical arthritis scores (data are mean ± SD, n = 6, *P < 0.05, **P < 0.01, ***P < 0.001 vs. Model). E Measurement of the pain domain (data are mean ± SD, n = 6, ###P < 0.001 vs. Control; *P < 0.05, **P < 0.01, ***P < 0.001 vs. Model). F The percentage of animals exhibiting any sign of disease (data are mean ± SD, n = 6, *P < 0.05, **P < 0.01 vs. Model). G Typical images of H&E staining (Bar = 50 μm) of the knee joints. H Histological scores (data are mean ± SD, n = 6, **P < 0.01 vs. Model)

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