Fig. 5
From: Tanshinone IIA inhibits osteoclastogenesis in rheumatoid arthritis via LDHC-regulated ROS generation
Tan IIA affects the enzymatic activity of the LDHC protein in vitro. A Tan IIA inhibits the enzymatic activity of the LDHC protein. B Tan IIA reduced NAD production in RAW 264.7 cells (data are mean ± SD, **P < 0.01, ***P < 0.001 vs. Control). Tan IIA induced ROS levels in RAW264.7 cells, as determined by flow cytometry (data are the mean ± SD, ***P < 0.001 vs. control) (C) and immunofluorescence (bar = 50 μm) (D)