Fig. 7From: Tanshinone IIA inhibits osteoclastogenesis in rheumatoid arthritis via LDHC-regulated ROS generationSchematic model showing the molecular mechanism of Tan IIA determined in this study. Tan IIA covalently binds to LDHC and inhibits its enzymatic activity, reducing the generation of NAD+, decreasing ROS accumulation and ultimately ameliorating bone destructionBack to article page