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  1. The drug resistance of tumor stem cells is an obstacle in gastric cancer (GC) treatment and the high expression of ABC transporters is a classic reason for drug resistance. This study aimed to construct a reli...

    Authors: Wenjie Huang, Fang Wen, Peixing Gu, Jiatong Liu, Yun Xia, Ye Li, Jiayu Zhou, Siyuan Song, Shuai Ruan, Suping Gu, Xiaoxue Chen and Peng Shu
    Citation: Chinese Medicine 2022 17:93
  2. Acupuncture combined with auricular acupressure has been used as a complementary and alternative treatment for smoking cessation in Hong Kong for over 10 years. This study aimed to investigate the success rate...

    Authors: Lai Fun Ho, Wai Kwan Ho, Ling Ling Wong, Sze Wan Chiu, Shuk Yu Tang, Chun Ming Wong, Kin San Chan, Chi Lan Lam, Min Chen, Kam Leung Chan, Guohua Lin, Bacon Fung-Leung Ng and Zhi Xiu Lin
    Citation: Chinese Medicine 2022 17:92
  3. One of the most challenging aspects of colon cancer (CC) prognosis and treatment is liver-tropic metastasis. Astragalus mongholicus Bunge—Curcuma aromatica Salisb. (AC) is a typical medication combination for the...

    Authors: Fuyan Liu, Yan Liang, Ruolan Sun, Weicheng Yang, Zhongqing Liang, Junfei Gu, Fan Zhao and Decai Tang
    Citation: Chinese Medicine 2022 17:91
  4. Hepatocellular carcinoma (HCC, accounting for 90% of primary liver cancer) was the sixth most common cancer in the world and the third leading cause of cancer death in 2020. The number of new HCC patients in C...

    Authors: Lai Wei, Zeyu Wang, Niancai Jing, Yi Lu, Jili Yang, Hongyu Xiao, Huanyu Guo, Shoukun Sun, Mingjing Li, Daqing Zhao, Xiangyan Li, Wenxiu Qi and Yue Zhang
    Citation: Chinese Medicine 2022 17:90
  5. Compound Turkish gall ointment (CTGO) has a long history of being widely used as a folk medicine in Xinjiang for the treatment of eczema. CTGO is currently in the pre-investigational new drug application stage...

    Authors: Xuan Ma, Meng Hao, Ming Hui Zhang, Ya Zeng, Qing Qing Yang, Lu Zhao, Chen Yang Fan, Zhi Hong Ji, Ke Ao Li, Zhi Jian Li, Mirzat Maimaiti and Ji Hong Nie
    Citation: Chinese Medicine 2022 17:89
  6. Since the outbreak of COVID-19 has resulted in over 313,000,000 confirmed cases of infection and over 5,500,000 deaths, substantial research work has been conducted to discover agents/ vaccines against COVID-1...

    Authors: Ka Man Yip, Kwan Ming Lee, Tzi Bun Ng, Shujun Xu, Ken Kin Lam Yung, Shaogang Qu, Allen Ka Loon Cheung and Stephen Cho Wing Sze
    Citation: Chinese Medicine 2022 17:88
  7. Chronic Urticaria (CU), a common skin disorder known as Yin Zhen in Chinese medicine, is characterized by recurrent, pruritic, pink-to-red edematous lesions and wheals on the skin. Xiao-Feng Powder (XFP, meani...

    Authors: Hing Yu Hung, Tianhe Song, Steven King Fan Loo, Kam Leung Chan, Jessica Yuet Ling Ching, Chi Him Sum, Louis Cho Wing Lo, Sarah Chon Pin Chia, Ray Tin Muk Ho, Pui Kuan Cheong, Tony Hon Chung Siu, Ka Chun Leung and Zhi-Xiu Lin
    Citation: Chinese Medicine 2022 17:87
  8. Bone tissue engineering (BTE) is a promising method for the repair of difficult-to-heal bone tissue damage by providing three-dimensional structures for cell attachment, proliferation, and differentiation. Tra...

    Authors: Zheng-Rong Gao, Yun-Zhi Feng, Ya-Qiong Zhao, Jie Zhao, Ying-Hui Zhou, Qin Ye, Yun Chen, Li Tan, Shao-Hui Zhang, Yao Feng, Jing Hu, Ze-Yue Ou-Yang, Marie Aimee Dusenge and Yue Guo
    Citation: Chinese Medicine 2022 17:86
  9. Bu-Shen-Huo-Xue (BSHX) decoction has been used in the postoperative rehabilitation of patients with spinal cord injury in China. In the present study, we aim to reveal the bioactive compounds in BSHX decoction...

    Authors: Yonghui Hou, Dan Luo, Yu Hou, Jiyao Luan, Jiheng Zhan, Zepeng Chen, Shunmei E, Liangliang Xu and Dingkun Lin
    Citation: Chinese Medicine 2022 17:85
  10. Lianhua Qingwen Capsules (LHQW) is a traditional Chinese medicine prescription commonly used to treat viral influenza in China. There has been sufficient evidence that LHQW could effectively treat COVID-19. Ne...

    Authors: Liang Hong, Min He, Shaoping Li and Jing Zhao
    Citation: Chinese Medicine 2022 17:84
  11. Alzheimer's Disease (AD) is a serious neurodegenerative disease and there is currently no effective treatment for AD progression. The use of TCM as a potential treatment strategy for AD is an evolving field of...

    Authors: Qianqian Huang, Chen Zhang, Shi Dong, Junwen Han, Sihao Qu, Tianshu Xie, Haibin Zhao and Yuanyuan Shi
    Citation: Chinese Medicine 2022 17:83
  12. Alzheimer’s disease (AD) is a neurodegenerative disease. Ferroptosis plays a critical role in neurodegenerative diseases. Nuclear factor E2-related factor 2 (Nrf2) is considered an important factor in ferropto...

    Authors: Sixia Yang, Zeping xie, Tingting Pei, Yi zeng, Qiaowu Xiong, Hui Wei, Yong Wang and Weidong Cheng
    Citation: Chinese Medicine 2022 17:82
  13. Immune checkpoint inhibitors that target programmed cell death protein 1 (PD-1) have obtained encouraging results, but a fraction of tumor patients failed to respond to anti-PD-1 treatment due to the existence...

    Authors: Qi Sun, Lin Xiao, Zhiying Cui, Yaping Yang, Junting Ma, Zhen Huang, Junfeng Zhang and Jiangning Chen
    Citation: Chinese Medicine 2022 17:81
  14. Acupuncture is widely used around the whole world nowadays and exhibits significant efficacy against many chronic diseases, especially in pain-related diseases. With the rapid development of artificial intelli...

    Authors: Yulin Wang, Xiuming Shi, Thomas Efferth and Dong Shang
    Citation: Chinese Medicine 2022 17:80
  15. Rheum tanguticum is utilized as one of the well known traditional Chinese medicine for the treatment of gastrointestinal diseases. Recently, R. tanguticum polysaccharides (RP) have received increasing attention d...

    Authors: Ding-Tao Wu, Qin Yuan, Kang-Lin Feng, Jinming Zhang, Ren-You Gan, Liang Zou and Shengpeng Wang
    Citation: Chinese Medicine 2022 17:79
  16. To systematically review the clinical efficacy and safety of Chinese herbal medicine (CHM) with and without Western medicine (WM) for different severity of COVID-19.

    Authors: Lu Li, Hongliang Xie, Ling Wang, Aolin Zhang, Xuan Mou, Yifan Lin, Hongli Ma, Yu Wang, Jian Li, Jingshu Gao, Chi Chiu Wang, Ping Chung Leung, Xiaohui Fan and Xiaoke Wu
    Citation: Chinese Medicine 2022 17:77
  17. There is no comprehensive treatment method for hepatocellular carcinoma (HCC); hence, research and development are still focused on systemic therapies, including drugs. Sinikangai fang (SNKAF) decoction, a cla...

    Authors: Wei Guo, Xiaohui Yao, Siyuan Lan, Chi Zhang, Hanhan Li, Zhuangzhong Chen, Ling Yu, Guanxian Liu, Yuan Lin, Shan Liu and Hanrui Chen
    Citation: Chinese Medicine 2022 17:76
  18. Investigation on protective effects of Panax notoginseng against obesity and its related mechanisms is incomplete. Present study aimed to investigate the potential anti-obesity effect of the total saponins (PNS) ...

    Authors: Yi Tan, Xutao Zhang, Yan Zhou, Lingchao Miao, Baojun Xu, Haroon Khan, Yitao Wang, Hua Yu and Wai San Cheang
    Citation: Chinese Medicine 2022 17:75
  19. Inflammatory bowel disease (IBD) is a chronic recurrent inflammatory disease of the intestine, including Crohn’s disease (CD) and ulcerative colitis (UC), whose etiology and pathogenesis have not been fully un...

    Authors: Shuo Yuan, Qi Wang, Jiao Li, Jia-Chen Xue, You Li, Huan Meng, Xiao-Ting Hou, Ji-Xing Nan and Qing-Gao Zhang
    Citation: Chinese Medicine 2022 17:74
  20. NLRP3 inflammasome activation and pyroptosis play a significant role in myocardial ischemia reperfusion injury (MI/RI). Geniposide was reported to show potential therapeutic use for MI/RI with its anti-inflamm...

    Authors: Haiyan Li, Dong-Hua Yang, Yanmei Zhang, Fuchun Zheng, Fenfei Gao, Jiajia Sun and Ganggang Shi
    Citation: Chinese Medicine 2022 17:73
  21. Many studies have assessed the fingerprint and quantitative analysis of Ginkgo biloba preparations, but the fingerprint mainly focuses on flavonoid glycosides. However, according to our previous study, the dif...

    Authors: Li-na Liu, Hong-yu Jin, Zan Ke, Wei-yi Xu, Lei Sun and Shuang-cheng Ma
    Citation: Chinese Medicine 2022 17:72
  22. Rheumatoid arthritis (RA) is a chronic and refractory autoimmune disease. Deficiency pattern (DP) and excess pattern (EP), as crucial types of Chinese medicine pattern diagnoses published by International Clas...

    Authors: Bin Liu, Hongtao Guo, Li Li, Qi Geng, Ning Zhao, Yong Tan, Zhixing Nie, Guilin Ouyang, Aiping Lu and Cheng Lu
    Citation: Chinese Medicine 2022 17:71
  23. Recent years, a soaring number of marketed Trifolium pratense (red clover) extract products have denoted that a rising number of consumers are turning to natural alternatives to manage postmenopausal symptoms. T....

    Authors: Yixian Quah, Jireh Chan Yi-Le, Na-Hye Park, Yuan Yee Lee, Eon-Bee Lee, Seung-Hee Jang, Min-Jeong Kim, Man Hee Rhee, Seung-Jin Lee and Seung-Chun Park
    Citation: Chinese Medicine 2022 17:70
  24. Cholangiocarcinoma (CCA) is a rare biliary adenocarcinoma related to poor clinical prognosis. Crowberry is an herbal medicine used to control inflammatory diseases and reestablish antioxidant enzyme activity. ...

    Authors: Xue Wang, Xuebing Zhou, Ludan Zhang, Xin Zhang, Chunyu Yang, Yingshi Piao, Jinhua Zhao, Lili Jin, Guihua Jin, Renbo An and Xiangshan Ren
    Citation: Chinese Medicine 2022 17:69
  25. Parkinson’s disease (PD) is a progressive neurodegenerative disease common in aged populations. Classified by Hoehn & Yahr stages, patients are often divided into mild/early stage, moderate/middle stage, and a...

    Authors: Yuqing Hu, Sichun Gu, Xiaolei Yuan, Hui Li, Canxing Yuan and Qing Ye
    Citation: Chinese Medicine 2022 17:68
  26. The acupoint selections impact the effects of acupuncture, and preliminary evidence showed potential connection between pain threshold (PT) and acupuncture response. This study examined whether acupuncture at ...

    Authors: Jiali Liu, Ying Li, Ling Li, Xiaochao Luo, Ning Li, Xuguang Yang, Hongxing Zhang, Zhibin Liu, Deying Kang, Yanan Luo, Yanmei Liu, Yulong Jia, Yan Ren, Minghong Yao, Yuning Wang, Jin Chen…
    Citation: Chinese Medicine 2022 17:67
  27. Isatis tinctoria L (PLG) is a medicinal herb from the roots of Isatis indigotica Fort (Family Cruciferae). Previous studies have shown that PLG has anti-inflammatory and therapeutic effects against conditions suc...

    Authors: Ga-Yul Min, Tae In Kim, Ji-Hye Kim, Won-Kyung Cho, Ju-Hye Yang and Jin-Yeul Ma
    Citation: Chinese Medicine 2022 17:66
  28. Fresh or dried Persimmon leaves (Diospyros kaki Thunb.) exhibit preventive effects on cardiovascular and cerebrovascular diseases. However, their antidepressant effects and underlying mechanisms are unclear. Thus...

    Authors: Hui Yu, Shumin Shao, Junnan Xu, Haibiao Guo, Zhangfeng Zhong and Jiangping Xu
    Citation: Chinese Medicine 2022 17:65
  29. The description of controls is important in acupuncture clinical trials to interpret its effectiveness without fallacy. This paper aims to evaluate the reporting quality of acupuncture studies on the character...

    Authors: Ye-Seul Lee, Song-Yi Kim, Mariah Kim, Minseo Kim, Jiyoon Won, Hyangsook Lee, Myeong Soo Lee and Younbyoung Chae
    Citation: Chinese Medicine 2022 17:64
  30. Alopecia affects millions of individuals globally, with hair loss becoming more common among young people.  Various traditional Chinese medicines (TCM) have been used clinically for treating alopecia, however,...

    Authors: Xiaojiao Fan, Jing Chen, Yajun Zhang, Siyi Wang, Wenqian Zhong, Huipu Yuan, Xia Wu, Chaochen Wang, Yixin Zheng, Yuan Wei and Ying Xiao
    Citation: Chinese Medicine 2022 17:63
  31. Traditional Chinese medicine (TCM) has a long history, rich clinical experience, and unique advantages in the prevention and treatment of diseases. The quality and safety of Chinese medicinal materials (CMMs) ...

    Authors: Dazhong Zhao, Zunzhe Tian, Jing Cai and Juan He
    Citation: Chinese Medicine 2022 17:61
  32. Many studies about depression have focused on the dysfunctional synaptic signaling in the hippocampus that drives the pathophysiology of depression. Radix Bupleuri has been used in China for over 2000 years to re...

    Authors: Chen-Yue Liu, Jian-Bei Chen, Yue-Yun Liu, Xue-Ming Zhou, Man Zhang, You-Ming Jiang, Qing-Yu Ma, Zhe Xue, Zong-Yao Zhao, Xiao-Juan Li and Jia-Xu Chen
    Citation: Chinese Medicine 2022 17:60
  33. Traditional Chinese medicine and Western medicine combination (TCM-WMC) increased the complexity of compounds ingested.

    Authors: Zhao Chen, Mengzhu Zhao, Liangzhen You, Rui Zheng, Yin Jiang, Xiaoyu Zhang, Ruijin Qiu, Yang Sun, Haie Pan, Tianmai He, Xuxu Wei, Zhineng Chen, Chen Zhao and Hongcai Shang
    Citation: Chinese Medicine 2022 17:58
  34. Myocardial fibrosis changes the structure of myocardium, leads to cardiac dysfunction and induces arrhythmia and cardiac ischemia, threatening patients’ lives. Electroacupuncture at PC6 (Neiguan) was previousl...

    Authors: Wenchuan Qi, Xiang Li, Yanrong Ren, Xueying Liu, Hongjuan Fu, Xiao Wang, Xiao Li, Jian Xiong, Qianhua Zheng, Dingjun Cai and Fanrong Liang
    Citation: Chinese Medicine 2022 17:57
  35. The unripe fruits of Rubus chingii Hu. (“Fu-peng-zi” in Chinese) is a well-known herbal tonic in traditional Chinese medicine (TCM) for tonifying liver and kidney. However, little is known regarding its therapeut...

    Authors: Jianjun Wu, Dingqi Zhang, Bo Zhu, Siqi Wang, Yongbin Xu, Congcong Zhang, Hailing Yang, Shunchun Wang, Ping Liu, Luping Qin and Wei Liu
    Citation: Chinese Medicine 2022 17:56
  36. Triple-negative breast cancer (TNBC) is a highly aggressive subtype of breast cancer that develops resistance to chemotherapy frequently. Autophagy has been reported as a pro-survival response to chemotherapeu...

    Authors: Shuang Zhang, Yu Dong, Xiuping Chen, Chris Soon Heng TAN, Min Li, Kai Miao and Jia-Hong Lu
    Citation: Chinese Medicine 2022 17:55
  37. The processing of medicinal plant materials is one of the important factors influencing the components and biological activities of TCMs. Smilax glabra Roxb. is an herbal vine widely distributed in China, and its...

    Authors: Juanjuan Qiao, Gengyu Lu, Gang Wu, Hui Liu, Wanli Wang, Tianmao Zhang, Guoyong Xie and Minjian Qin
    Citation: Chinese Medicine 2022 17:54
  38. Acupuncture at Neiguan (PC6) has long been used for treating cardiovascular diseases, but its antiarrhythmic effect and the underlying mechanisms have not yet been well investigated, especially regarding prema...

    Authors: Hao Hong, Xin Cao, Tian Deng, Xiang-Min Meng, Yu-Meng Li, Li-Juan Zhu, Jing Lv, Xuan Li, Shu-Guang Yu and Bing-Mei Zhu
    Citation: Chinese Medicine 2022 17:52
  39. Hemorrhagic transformation (HT) is a common complication of delayed tissue plasminogen activator (t-PA) treatment for ischemic stroke. Peroxynitrite plays an important role in the breakdown of blood–brain barr...

    Authors: Hansen Chen, Yunxia Luo, Bun Tsoi, Bing Gu, Suhua Qi and Jiangang Shen
    Citation: Chinese Medicine 2022 17:51
  40. Rhei Radix et Rhizoma (rhubarb), as one of the typical representatives of multi-effect traditional Chinese medicines (TCMs), has been utilized in the treatment of various diseases due to its multicomponent nat...

    Authors: Jia-Qian Chen, Yan-Yan Chen, Xia Du, Hui-Juan Tao, Zong-Jin Pu, Xu-Qin Shi, Shi-Jun Yue, Gui-Sheng Zhou, Er-Xin Shang, Yu-Ping Tang and Jin-Ao Duan
    Citation: Chinese Medicine 2022 17:50
  41. We aim to study the clinical effect of moxibustion at Laogong interval with Panax notoginseng on the short-term maturation and long-term patency of arteriovenous fistula.

    Authors: Yurou Chen, Lin Xu, Di Huang, Dongping Chen, Feng Wu, Luobing Wang, Jie Zhou, Tianying Lan, Xuehua Qin and Chaoyang Ye
    Citation: Chinese Medicine 2022 17:49
  42. Low-frequency electroacupuncture (EA) has been shown to ameliorate obesity and reproductive dysfunctions in patients with polycystic ovary syndrome (PCOS), and further explorations in PCOS-like rats showed tha...

    Authors: Hongru Gao, Xiaoyu Tong, Wei Hu, Yicong Wang, Kuinyu Lee, Xiaoqing Xu, Jiemei Shi, Zhenle Pei, Wenhan Lu, Yuning Chen, Ruonan Zhang, Zheyi Wang, Ziyu Wang, Chengzhi Han, Yu Wang and Yi Feng
    Citation: Chinese Medicine 2022 17:48
  43. Precision medicine aims to address the demand for precise therapy at the gene and pathway levels. We aimed to design software to allow precise treatment of osteoporosis (OP) with Chinese medicines (CMs) at the...

    Authors: Jinyu Li, Guiyu Feng, Haoyang He, Haolin Wang, Jia Tang, Aiqing Han, Xiaohong Mu and Weifeng Zhu
    Citation: Chinese Medicine 2022 17:47
  44. Leonuri Herba (Yimucao) is a very common Chinese herbs for treating menstrual and maternal diseases for thousands of years in China. However, the herb collected in different origins was easily found in the mar...

    Authors: Kelly Yinching Lam, Yinghao Wang, Tszking Lam, Chuenfai Ku, Wingping Yeung and Zhongzhen Zhao
    Citation: Chinese Medicine 2022 17:46
  45. The present quality control method of Chinese medicinal materials (CMM) has obvious deficiency, which cannot be compatible with the multi-target and multi-component characteristics and production process of CM...

    Authors: Qi Xiao, Xinlu Mu, Jiushi Liu, Bin Li, Haitao Liu, Bengang Zhang and Peigen Xiao
    Citation: Chinese Medicine 2022 17:45
  46. Xian-ling-lian-xia-fang (XLLXF), a Chinese medicine decoction, is widely used in the treatment of triple negative breast cancer (TNBC). However, the underlying mechanism of XLLXF in TNBC treatment has not been...

    Authors: Feifei Li, Youyang Shi, Yang Zhang, Xiaojuan Yang, Yi Wang, Kexin Jiang, Ciyi Hua, Chunyu Wu, Chenping Sun, Yuenong Qin and Sheng Liu
    Citation: Chinese Medicine 2022 17:44
  47. To investigate how the ulcerative colitis (UC) be treated with Chinese herbal medicines (CHM), using Chinese medicine (CM) pattern (zheng) identification, in the current clinical practice.

    Authors: Xuan Zhang, Lin Zhang, Jacky C. P. Chan, Xihong Wang, Chenchen Zhao, Ying Xu, Weifeng Xiong, Wai Chak Chung, Feng Liang, Xu Wang, Jiangxia Miao and Zhaoxiang Bian
    Citation: Chinese Medicine 2022 17:43