This study aims to investigate the leukogenic effect of astragalus polysaccharide (APS), to compare its effect of increasing the numbers of mature granulocytes with that of granulocyte colony-stimulating facto...
Authors: Ping-Ping Zhang, Zhao-Ting Meng, Liu-Chun Wang, Lei-Ming Guo and Kai Li
The Chinese medicine herb pair Flos Lonicerae japonicae (FLJ) and Forsythiae fructus (FF), is a representative heat-clearing (qing re) and detoxifying (jie du) combination that exhibits many pharmacological activ...
Panax Notoginseng flower saponins (PNFS) are the main active component of Panax notoginseng (Burk) F. H. Chen flower bud (PNF) and possess significant anti-inflammatory efficacy. This ...
Authors: Xiao-Xu Peng, Shu-Hui Zhang, Xiao-Ling Wang, Ting-Jie Ye, Hua Li, Xiao-Feng Yan, Li Wei, Zhong-Ping Wu, Jing Hu, Chun-Pu Zou, You-Hua Wang and Xu-Dong Hu
Ougan (Citrus reticulata cv. Suavissima) flavedo extract (OFE) exhibited potential anti-tumor effects with unclear underlying mechanisms. This study aims to evaluate the potential anti-metastatic activities of OF...
Authors: Linlin Chang, Sheng Jia, Yingying Fu, Tianyi Zhou, Ji Cao, Qiaojun He, Bo Yang, Xian Li, Chongde Sun, Dan Su, Hong Zhu and Kunsong Chen
Granule products produced from medicinal herbs are gaining popularity. However, there have been few studies comparing the quality or efficacy of granules with those of herbal formulations. This study aims to c...
Authors: Xian Zhou, Valentina Razmovski-Naumovski and Kelvin Chan
Acupuncture and moxibustion are more integrated in the Chinese healthcare system than in the national healthcare systems of other countries. Development of acupuncture and moxibustion in China is making progre...
Authors: Min Yee Lim, Jian Huang, Baixiao Zhao and Lue Ha
Qing-Yi Decoction (QYD) has been used for severe acute pancreatitis (SAP) patients in China for many years. There were two kinds of QYD: Num 1. QYD (QYD1) which is used in the acute response st...
Authors: Weiwei Chen, Xiaonan Yang, Lei Huang, Ping Xue, Meihua Wan, Jia Guo, Lin Zhu, Tao Jin, Zongwen Huang, Guangyuan Chen, Wenfu Tang and Qing Xia
You-Gui pills (You-Gui-Wan; YGW) can promote T lymphocyte proliferation and differentiation, and restore Th1/Th2 balance in the treatment of asthma, but their mechanism of action is not fully known. This study ai...
Authors: Hong Ping Zhang, Juan Juan Fu, Tao Fan, Wen Bin Zhang, Zeng Li Wang, Lei Wang and Gang Wang
Sterol regulatory element binding protein-1c (SREBP-1c) is a regulator of the lipogenic pathway and is transcriptionally activated by liver X receptor α (LXRα). This study aims to investigate phytochemicals in...
Authors: Gyun-Sik Oh, Gang Gu Lee, Jin Yoon, Won Keun Oh and Seung-Whan Kim
Liver fibrosis is a wound-healing response to chronic liver injury characterized by progressive inflammation and deposition of extracellular matrix components. The pathological condition of liver fibrosis invo...
Authors: Shao-Ru Chen, Xiu-Ping Chen, Jin-Jian Lu, Ying Wang and Yi-Tao Wang
Kaempferol has been reported as beneficial for both acute and chronic inflammatory diseases. This study aims to investigate whether kaempferol affects systemic inflammation and oxidative stress in the heart, l...
Authors: Qi-Sheng Yang, Li-Ping He, Xian-Long Zhou, Yan Zhao, Jun Shen, Peng Xu and Shao-Zhou Ni
Bufothionine is an alkaloid in Cinobufacini (Huachansu). This study aims to investigate the effects of bufothionine on liver tumors and acute liver injury.
Authors: Rui-Fang Xie, Zhi-Cheng Li, Pei-Pei Chen and Xin Zhou
Chrysin (5,7-dihydroxyflavone) inhibits platelet-derived growth factor-induced vascular smooth muscle cell proliferation and arterial intima hyperplasia. This study aims to investigate the effects of chrysin o...
Authors: Xian-Wei Li, Xiang-Ming Wang, Shu Li and Jie-Ren Yang
Pineapple (Ananas comosus) was demonstrated to be hepatoprotective. This study aims to investigate the reversing effects of pineapple vinegar on paracetamol-induced liver damage in murine model.
Authors: Nurul Elyani Mohamad, Swee Keong Yeap, Kian Lam Lim, Hamidah Mohd Yusof, Boon Kee Beh, Sheau Wei Tan, Wan Yong Ho, Shaiful Adzni Sharifuddin, Anisah Jamaluddin, Kamariah Long, Nik Mohd Afizan Nik Abd Rahman and Noorjahan Banu Alitheen
Rhizoma Chuanxiong (RC) is the dried rhizome of Ligusticum chuanxiong Hort., and various types of processed Rhizoma Chuanxiong (PRC) are widely used in China. However, quality assurance and quality control of the...
Authors: Jia-Yan Fang, Lin Zhu, Tao Yi, Jian-Ye Zhang, Ling Yi, Zhi-Tao Liang, Li Xia, Jia-Fu Feng, Jun Xu, Yi-Na Tang, Zhong-Zhen Zhao and Hu-Biao Chen
DNA in herbal decoctions is usually fragmented by extensive boiling and is usually regarded as unsuitable for molecular authentication. This study aims to evaluate the feasibility for molecular authentication ...
During chronic liver injury, hepatic stellate cells (HSC) are activated and proliferate, which causes excessive extracellular matrix (ECM) deposition, leading to scar formation and fibrosis. Medicinal plants a...
Authors: Florent Duval, Jorge E Moreno-Cuevas, María Teresa González-Garza, Carlos Rodríguez-Montalvo and Delia Elva Cruz-Vega
The total flavonoids from ethanol extract of the aerial part of Ziziphora clinopodioides Lam. (Lamlaceae) (Xintahua) showed protective activities against rat acute myocardial ischemia in rats. This study aims to ...
Authors: Wei-Jun Yang, Chong Liu, Zheng-Yi Gu, Xing-Yue Zhang, Bo Cheng, Yan Mao and Gui-Peng Xue
Wild Rheum tanguticum (Dahuang in Chinese) has becoming endangered in China. This study aims to examine the genetic structure and genetic diversity of R. tanguticum within species, and the genetic differentiation...
Authors: Xiaoqin Zhang, Ying Liu, Xuan Gu, Zhengzheng Guo, Li Li, Xiaona Song, Siqi Liu, Yimei Zang, Yanpeng Li, Chunsheng Liu and Shengli Wei
The land and ecology suitability for producing pollution-free Chinese medicinal materials should be evaluated based on Geographic Information System (GIS). This study aims to determine production regions for p...
Authors: Cai-xiang Xie, Huan Wang, Lin-fang Huang, Hui Li and Jing-yuan Song
The role of “Jun-Chen-Zuo-Shi” (also known as “sovereign-minister-assistant-courier”) component herbs of Chinese medicine is not fully understood. This study aims to test the “Jun-Chen-Zuo-Shi” rule with the QiSh...
Authors: Leihong Wu, Yi Wang, Zheng Li, Boli Zhang, Yiyu Cheng and Xiaohui Fan
The Chinese medicine formulation ISF-1 (also known as Bu-Yang-Huan-Wu-Tang) for post-stroke rehabilitation could increase the expression of growth-regulating protein follistatin by approximately 4-fold. This stud...
Authors: Chuanbin Yang, Xuechen Li and Jianhui Rong
This study interviewed community pharmacists in Shanghai and Guangzhou for their perception of the popular categories of over-the-counter (OTC) Chinese medicines and the factors affecting customer preferences ...
Chaihu, prepared from the dried roots of Bupleurum Chinense DC (also known as bei Chaihu in Chinese) or Bupleurum scorzoneraefolium WILD (also known as nan Chaihu in Chinese), is a herbal medicine for harmonizing...
Authors: Betty Yuen-Kwan Law, Jing-Fang Mo and Vincent Kam-Wai Wong
Panax ginseng (Ren shen) has been used to treat chronic obstructive pulmonary disease (COPD). This article aims to present a study protocol and pilot trial comparing P. ginseng with placebo for treating moderate ...
Authors: Lei Wu, Anthony Lin Zhang, Yuan Ming Di, Johannah Linda Shergis, Yuanbin Chen, Xinfeng Guo, Zehuai Wen, Francis Thien, Christopher Worsnop, Lin Lin and Charlie Changli Xue
Some protein pharmaceuticals from Chinese medicine have been developed to treat cardiovascular diseases, genetic diseases, and cancer. Bioactive proteins with various pharmacological properties have been succe...
Authors: Kam Lok Wong, Ricky Ngok Shun Wong, Liang Zhang, Wing Keung Liu, Tzi Bun NG, Pang Chui Shaw, Philip Chi Lip Kwok, Yau Ming Lai, Zhang Jin Zhang, Yanbo Zhang, Yao Tong, Ho-Pan Cheung, Jia Lu and Stephen Cho Wing Sze
Frankincense (Boswellia carterii, known as Ru Xiang in Chinese) and sandalwood (Santalum album, known as Tan Xiang in Chinese) are cancer preventive and therapeutic agents in Chinese medicine. Their biologically ...
Authors: Mikhail G Dozmorov, Qing Yang, Weijuan Wu, Jonathan Wren, Mahmoud M Suhail, Cole L Woolley, D Gary Young, Kar-Ming Fung and Hsueh-Kung Lin
Extracts and compounds of natural products have potential as alternatives to current Western medicines. However, these products may not be patentable under the statutory requirements because of their naturally...
Authors: Alice Yuen-Ting Wong and Albert Wai-Kit Chan
It has been demonstrated that platycodin D (PD) exhibits anti-cancer activities. This study aims to investigate the anti-proliferative effects of the combination of PD and doxorubicin (DOX) on human breast can...
Authors: Zheng-Hai Tang, Ting Li, Hong-Wei Gao, Wen Sun, Xiu-Ping Chen, Yi-Tao Wang and Jin-Jian Lu
Cordyceps cicadae is a medicinal fungus that is often used for treating cancer. However, the anticancer mechanisms of C. cicadae are largely unknown. This study aims to investigate the anticancer mechanisms of C....
Authors: Hualin Wang, Jing Zhang, Wai-Hung Sit, Chung-Yung Jetty Lee and Jennifer Man-Fan Wan
Isodeoxyelephantopin (IDOE) isolated from Elephantopus scaber L. (Didancao) is used in Chinese medicine for the treatment of some types of cancer. The anti-cancer mechanism of IDOE remains unclear. This study aim...
Some Chinese herbs are anti-thrombolysis, and anti-inflammatory, improves brain RNA content, promotes brain protein synthesis, enhances dopamine function, regulates brain hormones, and improves microcirculatio...
Cratoxylum formosum (Jack) Dyer ssp. pruniflorum (Kurz) Gogel. (Hóng yá mù) (CF) has been used for treatment of fever, cough, and peptic ulcer. Previously, a 50% ethanol-water extract from twigs of CF was shown h...
Authors: Apiyada Nonpunya, Natthida Weerapreeyakul and Sahapat Barusrux
Nasopharyngeal carcinoma (NPC) has a high incidence rate in Southern China. Although there are conventional therapies, the side effects and toxicities are not always tolerable for patients. Recently, the tumor...
Authors: Carmen Ka-Man Law, Hoi-Hin Kwok, Po-Ying Poon, Chi-Chiu Lau, Zhi-Hong Jiang, William Chi-Shing Tai, Wendy Wen-Luan Hsiao, Nai-Ki Mak, Patrick Ying-Kit Yue and Ricky Ngok-Shun Wong
Tongue diagnosis in traditional Chinese medicine (TCM) assesses the health by investigation of tongue coating. The science and technology of tongue coating analysis have become a significant issue for moderniz...
Tree bark of Eucommia ulmoides Oliv., (commonly well-known as “Du-zhong” in China), has been used to treat hypertension, hypercholesterolemia, hyperglycemia, hepatic fibrosis and renal injury. This study aims to ...
Visual inspection for tongue analysis is a diagnostic method in traditional Chinese medicine (TCM). Owing to the variations in tongue features, such as color, texture, coating, and shape, it is difficult to pr...
Authors: Miao-Jing Shi, Guo-Zheng Li, Fu-Feng Li and Chao Xu
It was reported that 64% of tic disorder patients used complementary and alternative medicine. This review aims to evaluate the efficacy of herbal medicines in treating tic disorders.
Authors: Yun Hee Kim, Chang-Gue Son, Bon-Cho Ku, Hye Won Lee, Hyun Sook Lim and Myeong Soo Lee
Bupleurum marginatum Wall. ex DC (Apiaceae) is a perennial herb widely used in traditional Chinese and Kampo medicine for the treatment of various infectious diseases. The biological activities of B. marginatum h...
Authors: Mohamed L Ashour, Mahmoud Z El-Readi, Razan Hamoud, Safaa Y Eid, Sherweit H El Ahmady, Endalkachew Nibret, Florian Herrmann, Mahmoud Youns, Ahmed Tahrani, Dorothea Kaufmann and Michael Wink
Hyperglycemia induces activation of the c-Jun N-terminal kinase (JNK) pathway, which suppresses insulin gene expression and reduces DNA binding of pancreatic and duodenal homeobox factor (PDX)-1. This study ai...
Authors: MohammedTalaat Abdel Aziz, Mohammed Farid El-Asmar, Ameen Mahmoud Rezq, MohammedAbdel Aziz Wassef, Hanan Fouad, Nagwa Kamal Roshdy, Hanan Hosni Ahmed, Laila Ahmed Rashed, Dina Sabry, Fatma Mohammed Taha and Amira Hassouna
This study aims to establish a diagnostic scoring scheme for Shanghuo (Heatiness) and to evaluate whether Shanghuo is associated with biochemical parameters of salivary lysozyme (LYZ), salivary secreted immunoglo...
Authors: Sijun Liu, Zhaosheng Huang, Qingguang Wu, Zhangjie Huang, Lirong Wu, Wenli Yan, David Lungpao Chang, Zheng Yang and Zongwei Wang
There are approximately five Zhengs reported in psoriatic patients. Systematic data collection and proper analysis for the classification of psoriasis have been lacking. This study aims to cluster the Zhengs in p...
Authors: Xuesong Yang, Virasakdi Chongsuvivatwong, Sanguan Lerkiatbundit, Jianzhou Ye, Xiaoyong Ouyang, Enpin Yang and Hutcha Sriplung
The differentiation resp. death of human monocytic THP-1 cells induced by polysaccharide extracts of the medicinal mushrooms Phellinus linteus, Agaricus bisporus and Agaricus brasiliensis have been studied. This ...
Authors: Leo JLD van Griensven and Harrie A Verhoeven
Analysis of the relationship between the nervous system anatomy and the therapeutic characteristics of all acupuncture points in the channel network may provide new insights on the physiological mechanisms und...
Adenosine triphosphate-cassette binding protein (ABC) type G is considered as a part of reverse cholesterol transport (RCT) process in modification and metabolism of plasma and tissue cholesterol. This study a...
Authors: Abbass Ghanbari-Niaki and Saleh Rahmati-Ahmadabad
Bacterial conversion of ginsenosides is crucial for the health-promoting effects of ginsenosides. Previous studies on the biotransformation of ginsenoside Rb1 (Rb1) by gut bacteria have focused on the ginsenos...
Authors: Hong Shen, Weng-Im Leung, Jian-Qing Ruan, Song-Lin Li, JackyPui-Cheong Lei, Yi-Tao Wang and Ru Yan
Antrodia cinnamomea (AC) is an endemic mushroom species of Taiwan, and has been demonstrated to possess diverse biological and pharmacological activities, such as anti-hypertension, anti-hyperlipidemia, anti-infl...
