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  1. Irritable bowel syndrome (IBS) is a common gastrointestinal functional disease. Adults with IBS may experience abdominal pain, change of bowel habits, and abnormal stool form without organic disease. IBS can s...

    Authors: Ya Zheng, Jessica Ching, Chung Wah Cheng, Wai Ching Lam, Kam Leung Chan, Xuan Zhang, Pui Yan Lam, Xing Yao Wu, Linda L. D. Zhong, Pei Hua Cao, Cho Wing Lo, Pui Kuan Cheong, Zhixiu Lin, Matthew Koh, Justin Wu and Zhao Xiang Bian
    Citation: Chinese Medicine 2021 16:117
    Content type: Research Published on:

  2. Arsenic (As3+) is a carcinogen with considerable environmental and occupational relevancy. Its mechanism of action and methods of prevention remain to be investigated. Previous studies have demonstrated that ROS ...

    Authors: Yuan-Ye Dang, Hua Luo, Yong-Mei Li, Yang Zhou, Xiu Luo, Shui-Mu Lin, Shou-Ping Liu, Simon Ming-Yuen Lee, Chu-Wen Li and Xiao-Yan Dai
    Citation: Chinese Medicine 2021 16:116
    Content type: Research Published on:

  3. Non-alcoholic fatty liver disease (NAFLD) is characterized by ectopic accumulation of triglycerides in the liver. Emerging evidence has demonstrated that lipophagy regulates lipid mobilization and energy homeo...

    Authors: Jingxin Liu, Tian Zhang, Jianzhong Zhu, Shuangchen Ruan, Rongsong Li, Bing Guo and Ligen Lin
    Citation: Chinese Medicine 2021 16:115
    Content type: Research Published on:

  5. Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease dominated by synovial hyperplasia and bone destruction. The male flower of Eucommia ulmoides Oliv. (EF) has been shown to exert effects on the in...

    Authors: Yan Zhang, Jian-Ying Wang, Hao Wang, Xiao-Yun Chen, Lei Zhang and Ying Yuan
    Citation: Chinese Medicine 2021 16:113
    Content type: Research Published on:

  6. Fibrotic liver injury is a progressive scarring event, which may permanently affect liver function and progress into devastating end-stage liver diseases due to the absence of effective therapies. Si-Wu-Tang (...

    Authors: Xiaoyong Xue, Jianzhi Wu, Mingning Ding, Feng Gao, Fei Zhou, Bing Xu, Mingjun Lu, Jun Li and Xiaojiaoyang Li
    Citation: Chinese Medicine 2021 16:112
    Content type: Research Published on:

  7. Common chronic wounds include diabetic ulcers, venous ulcers, and pressure ulcers. The traditional Chinese medicine Huiyang Shengji decoction (HYSJD) has been shown to promote the healing of diabetic chronic w...

    Authors: Qingwu Liu, Jinchao Zhang, Xuyang Han, Jia Chen, Yating Zhai, Yan Lin, Huike Ma, Fang Feng, Xiujuan He and Ping Li
    Citation: Chinese Medicine 2021 16:111
    Content type: Research Published on:

  8. Uncaria tomentosa, which has similar chemical constituents with Uncaria rhynchophylla, has been reported to alleviate cognitive impairments in Alzheimer’s disease (AD) animal models. This study aimed to compare t...

    Authors: Qing-Qing Xu, Pang Chui Shaw, Zhen Hu, Wen Yang, Siu-Po Ip, Yan-Fang Xian and Zhi-Xiu Lin
    Citation: Chinese Medicine 2021 16:110
    Content type: Research Published on:

  9. Traditional Chinese Medicine (TCM) is distinguished by Syndrome differentiation, which prescribes various formulae for different Syndromes of same disease. This study aims to investigate the underlying mechanism.

    Authors: Gaosong Wu, Jing Zhao, Jing Zhao, Nixue Song, Ningning Zheng, Yuanyuan Zeng, Tingting Yao, Jingfang Zhang, Jieqiong Weng, Mengfei Yuan, Hu Zhou, Xiaoxu Shen, Houkai Li and Weidong Zhang
    Citation: Chinese Medicine 2021 16:109
    Content type: Research Published on:

  10. Coronary heart disease (CHD) is a common ischaemic heart disease whose pathological mechanism has not been fully elucidated. Single target drugs, such as antiplatelet aggregation, coronary artery dilation and ...

    Authors: Tian-Yi Cheng, Jia-Xin Li, Jing-Yi Chen, Pei-Ying Chen, Lin-Rui Ma, Gui-Lin Zhang and Pei-Yu Yan
    Citation: Chinese Medicine 2021 16:108
    Content type: Review Published on:

  11. Lily Bulb and Rehmannia Decoction (LBRD), is a traditional Chinese formula that has been shown to be safe and effective against depression; however, its material basis and pharmacological mechanisms remain unk...

    Authors: Hongxiu Zhang, Xiaoyan Xue, Jin Pan, Xiaobin Song, Xing Chang, Qiancheng Mao, Yanting Lu, Haijun Zhao, Yuan Wang, Xiansu Chi, Shijun Wang and Ke Ma
    Citation: Chinese Medicine 2021 16:107
    Content type: Research Published on:

  12. The wide spread of plasmid-mediated colistin resistance by mobile colistin resistance (MCR) in Enterobacteriaceae severely limits the clinical application of colistin as a last-line drug against bacterial infe...

    Authors: Qiushuang Sheng, Runbao Du, Cunhui Ma, Yonglin Zhou, Xue Shen, Xiaoning Hou, Lei Xu, Li Li, Xuming Deng and Jianfeng Wang
    Citation: Chinese Medicine 2021 16:106
    Content type: Research Published on:

  13. Neonatal hypoxic-ischemic encephalopathy (HIE) refers to the perinatal asphyxia caused by the cerebral hypoxic-ischemic injury. The current study was aimed at investigating the therapeutic efficacy of Scutella...

    Authors: Rui-Ze Niu, Liu-Lin Xiong, Hao-Li Zhou, Lu-Lu Xue, Qing-Jie Xia, Zheng Ma, Yuan Jin, Li Chen, Ya Jiang, Ting-Hua Wang and Jia Liu
    Citation: Chinese Medicine 2021 16:105
    Content type: Research Published on:

  15. Syndrome differentiation is a commonly used methodology and practice in Traditional Chinese Medicine (TCM) guiding the diagnosis and treatment of diseases including heart failure (HF). However, previous clinic...

    Authors: Alice Yeuk Lan Leung, Hoiyong Chen, Zhenhua Jia, Xinli Li and Jiangang Shen
    Citation: Chinese Medicine 2021 16:103
    Content type: Research Published on:

  17. Atopic dermatitis (AD) is a chronic relapsing skin disease characterized by recurring episodes of itchiness with skin erythema and surface damages. Chinese medicine (CM) is widely used for the management of AD...

    Authors: Chi Him Sum, Jessica Ching, Hongwei Zhang, Steven Loo, Cho Wing Lo, Mei Kwan Lai, Pui Kuan Cheong, Chau Leung Yu and Zhi-xiu Lin
    Citation: Chinese Medicine 2021 16:101
    Content type: Research Published on:

  18. American ginseng (AG) is a valuable medicine widely consumed as a herbal remedy throughout the world. Huge price difference among AG with different growth years leads to intentional adulteration for higher pro...

    Authors: Xiaowen Hu, Hua Yan, Xiaodong Wang, Zonghu Wang, Yuanpeng Li, Lianjun Zheng, Jianbo Yang, Wenguang Jing, Xianlong Cheng, Feng Wei and Shuangcheng Ma
    Citation: Chinese Medicine 2021 16:100
    Content type: Research Published on:

  19. Lei-gong-gen formula granule (LFG) is a folk prescription derived from Zhuang nationality, the largest ethnic minority among 56 nationalities in China. It consists of three herbs, namely Eclipta prostrata (L.) L....

    Authors: Qiaofeng Li, Taijin Lan, Songhua He, Weiwei Chen, Xiaolan Li, Weiquan Zhang, Ying Liu, Qiuping Zhang, Xin Chen, Yaoyao Han, Zhiheng Su, Dan Zhu and Hongwei Guo
    Citation: Chinese Medicine 2021 16:99
    Content type: Research Published on:

  20. Dried fruits of Psoralea corylifolia L. (Psoraleae Fructus) is one of the most popular traditional Chinese medicine with treatment for nephritis, spermatorrhea, pollakiuria, asthma, and various inflammatory disea...

    Authors: Qingxia Xu, Qian lv, Lu Liu, Yingtao Zhang and Xiuwei Yang
    Citation: Chinese Medicine 2021 16:98
    Content type: Research Published on:

  21. Chinese herbal medicine (CHM) has significant effects that improve the reproductive functions of patients with polycystic ovary syndrome (PCOS). However, the intergenerational effects of CHM on offspring and t...

    Authors: Xian Zhang, Lifang You, Xiaohui Zhang, Fangfang Wang, Yi Wang, Jue Zhou, Chang Liu and Fan Qu
    Citation: Chinese Medicine 2021 16:97
    Content type: Research Published on:

  22. Rheumatoid arthritis is a progressive and systemic autoimmune disease seriously compromises human health. Fibroblast like synoviocytes are the major effectors of proliferation and inflammation in rheumatoid ar...

    Authors: Lianhua He, Huijie Luan, Juan He, Miaomiao Zhang, Qingxia Qin, Yiping Hu, Yueming Cai, Desheng Sun, Yu Shi and Qingwen Wang
    Citation: Chinese Medicine 2021 16:96
    Content type: Research Published on:

  23. Chinese materia medica processing is a distinguished and unique pharmaceutical technique in Traditional Chinese Medicine (TCM) used for reducing side effects, and increasing or even changing therapeutic effica...

    Authors: Zhe Li, Lkhaasuren Ryenchindorj, Bonan Liu, Ji Shi, Chao Zhang, Yue Hua, Pengpeng Liu, Guoshun Shan and Tianzhu Jia
    Citation: Chinese Medicine 2021 16:95
    Content type: Research Published on:

  24. Marchantia polymorpha L. is a kind of Chinese herbal medicine and has various biological activities including antioxidant and antifungal. However, it is not clear about the antitumor effect and mechanism of M. po...

    Authors: Fangfang Zhou, Adila Aipire, Lijie Xia, Xierenguli Halike, Pengfei Yuan, Mamtimin Sulayman, Weilan Wang and Jinyao Li
    Citation: Chinese Medicine 2021 16:94
    Content type: Research Published on:

  25. The Gouqi-wentang formula (GQWTF) is a herbal formula used by Academician Xiao-lin Tong for the clinical treatment of T2DM. GQWTF is beneficial to qi, nourishes Yin, clears heat, and promotes fluid production,...

    Authors: Lin Han, Hao-yu Yang, Yu-jiao Zheng, Xiu-xiu Wei, Wen-chao Dan, Li-li Zhang, Qi-you Ding, Xu Ma, Xin-miao Wang, Lin-hua Zhao and Xiao-lin Tong
    Citation: Chinese Medicine 2021 16:93
    Content type: Research Published on:

  26. The oral colon-targeting drug delivery vehicle is vital for the efficient application of curcumin (Cur) in ulcerative colitis (UC) treatment because of its lipophilicity and instability in the gastrointestinal...

    Authors: Chen Zhang, Zhejie Chen, Yanan He, Jing Xian, Ruifeng Luo, Chuan Zheng and Jinming Zhang
    Citation: Chinese Medicine 2021 16:92
    Content type: Research Published on:

  27. Epimedin C, one of the main active ingredients of Epimedium, has been reported to have potential hepatotoxicity. However, the mechanism of Epimedin C-induced liver injury has not been studied. mRNA methylation...

    Authors: Zhizhen Song, Zeyun Li, Xueqian Wen, Ruijuan Liu and Xin Tian
    Citation: Chinese Medicine 2021 16:91
    Content type: Research Published on:

  28. Bungarus multicinctus, from which a classical Chinese medicine is produced, is known as the most venomous land snake in the world, but the chromatin organization and transcription factor activity during venom rep...

    Authors: Xuejiao Liao, Shuai Guo, Xianmei Yin, Baosheng Liao, Mingqian Li, He Su, Qiushi Li, Jin Pei, Jihai Gao, Juan Lei, Xiwen Li, Zhihai Huang, Jiang Xu and Shilin Chen
    Citation: Chinese Medicine 2021 16:90
    Content type: Research Published on:

  29. Fagopyrum dibotrys (F. dibotrys) (D.Don) H.Hara is a well-known edible herbal medicine in Asian countries. It has been widely used for the treatment of lung diseases, swelling, etc., and is also an important par...

    Authors: Le-Le Zhang, Yan He, Feiya Sheng, Ying-Fan Hu, Yu Song, Wei Li, Jiarong Chen, Jinming Zhang and Liang Zou
    Citation: Chinese Medicine 2021 16:89
    Content type: Review Published on:

  30. Amending from ancient classic, Ziyin Tongluo Formula (ZYTLF) has been prescribed to treat postmenopausal osteoporosis (PMOP) for decades with good curative effect. However, the possible mechanisms of it are st...

    Authors: Rong-Bin Chen, Ying-Dong Yang, Kai Sun, Shan Liu, Wei Guo, Jin-Xin Zhang and Yong Li
    Citation: Chinese Medicine 2021 16:88
    Content type: Research Published on:

  31. Microwave technology is used throughout the world to generate heat using energy from the microwave range of the electromagnetic spectrum. It is characterized by uniform energy transfer, low energy consumption,...

    Authors: Qi Hu, Yanan He, Fang Wang, Jing Wu, Zhimin Ci, Lumeng Chen, Runchun Xu, Ming Yang, Junzhi Lin, Li Han and Dingkun Zhang
    Citation: Chinese Medicine 2021 16:87
    Content type: Review Published on:

  32. With the advanced discoveries in the field of pathogenesis, a series of cerebral diseases, such as cerebral ischaemia, Alzheimer's disease, and depression, have been found to have multiple signalling targets i...

    Authors: Wenwen Zhang, Fangling Zhang, Qichao Hu, Xiaolin Xiao, Linbo Ou, Yuan Chen, Shiqing Luo, Yonghong Cheng, Yinxiao Jiang, Xiao Ma and Yanling Zhao
    Citation: Chinese Medicine 2021 16:86
    Content type: Review Published on:

  33. Belamcanda chinensis (L.) DC. (BC) belongs to the family of Iridaceae and is widely cultivated and used in many Chinese patent medicine and Chinese medicinal formulae. However, due to the high similarities in app...

    Authors: Hongxu Zhou, Yi Zhang, Hui Liang, Huijie Song, Jiaming Zhao, Li Liu, Jun Zeng, Lei Sun, Shuangcheng Ma and Dali Meng
    Citation: Chinese Medicine 2021 16:85
    Content type: Research Published on:

  35. Filifolium sibiricum (L.)Kitam (F. sibiricum), a compositae plant, is especially used to inhibit drug-resistant bacteria in folk medicine. Modern pharmacological studies also confirmed a variety of pharmacologica...

    Authors: Shaowa Lv, Qian Qiu, Qiuhong Wang and Haixue Kuang
    Citation: Chinese Medicine 2021 16:83
    Content type: Review Published on:

  36. Post-ischemic inflammation is a crucial component in stroke pathology in the early phase of cerebral ischemia–reperfusion (I/R) injury. Inflammation caused by microglia, astrocytes, and necrotic cells, produce...

    Authors: Chin-Yi Cheng, Su-yin Chiang, Shung-Te Kao and Shang-Chih Huang
    Citation: Chinese Medicine 2021 16:82
    Content type: Research Published on:

  40. Accumulating evidence indicated that necroptosis plays an essential role in the pathogenesis of inflammatory bowel disease (IBD). The O-linked β-N-acetylglucosaminylation (O-GlcNAcylation) of necroptotic signal m...

    Authors: Fan Wu, Qingqing Shao, Zhe Cheng, Xinyu Xiong, Ke Fang, Yan Zhao, Ruolan Dong, Lijun Xu, Fuer Lu and Guang Chen
    Citation: Chinese Medicine 2021 16:78
    Content type: Research Published on:

  41. Chaihu-Shugan-San (CSS, named Shihosogansan in Korean), a Chinese traditional medicine, is frequently used to treat anxiety and depression. Psychiatric disorders including depression are associated with gut dy...

    Authors: Sang-Kap Han, Jeon-Kyung Kim, Hee-Seo Park, Yeun-Jeong Shin and Dong-Hyun Kim
    Citation: Chinese Medicine 2021 16:77
    Content type: Research Published on:

  42. Paclitaxel-induced peripheral neuropathy (PIPN) is a challenging clinical problem during chemotherapy. Our previous work found that herbal formula Huangqi Guizhi Wuwu decoction (HGWD) could reduce oxaliplatin-...

    Authors: Zhangming Lv, Jiayun Shen, Xuejiao Gao, Yonglan Ruan, Jinying Ling, Rongwei Sun, Jingya Dai, Haizhen Fan, Xiaolan Cheng and Peng Cao
    Citation: Chinese Medicine 2021 16:76
    Content type: Research Published on:

  43. Ulcerative colitis (UC) is an important inflammatory phenotype in bowel disease (IBD), which is caused by multiple potential factors, including fungal dysbiosis. Candida albicans (C. albicans) was confirmed to be...

    Authors: Zhijun Han, Xiaofen Tan, Juan Sun, Tianming Wang, Guiming Yan, Changzhong Wang and Kelong Ma
    Citation: Chinese Medicine 2021 16:75
    Content type: Research Published on:

  44. With the advances in biomedical technologies, natural products have attracted substantial public attention in the area of drug discovery. Flavonoids are a class of active natural products with a wide range of ...

    Authors: Qichao Hu, Caiyan Qu, Xiaolin Xiao, Wenwen Zhang, Yinxiao Jiang, Zhao Wu, Dan Song, Xi Peng, Xiao Ma and YanLing Zhao
    Citation: Chinese Medicine 2021 16:74
    Content type: Review Published on:

  46. The biofilm state of pathogens facilitates antimicrobial resistance which makes difficult-to-treat infections. In this regard, it has been found that the compounds screened from plant extracts represent one ca...

    Authors: Lan Lu, Yuting Zhao, Guojuan Yi, Mingxing Li, Li Liao, Chen Yang, Chihin Cho, Bin Zhang, Jie Zhu, Kun Zou and Qiang Cheng
    Citation: Chinese Medicine 2021 16:72
    Content type: Research Published on:

  48. It is well-known that Prof. Tu Youyou won the Nobel Prize in Physiology or Medicine in 2015 due to the research on artemisinin treating malaria, and this can be regarded as the milestone of modernization of Tr...

    Authors: Hua Luo, Hongguo Chen, Chang Liu, Siyuan Zhang, Chi Teng Vong, Dechao Tan, Yuntao Dai, Yitao Wang and Shilin Chen
    Citation: Chinese Medicine 2021 16:70
    Content type: Review Published on:

  49. 3,3′,4,5′-tetramethoxy-trans-stilbene (3,3′,4,5′-TMS) and 3,4′,5-trimethoxy-trans-stilbene (3,4′,5-TMS) are two methoxy derivatives of resveratrol. Previous researches have proved that resveratrol and its analogu...

    Authors: Chunxiu Zhou, Xutao Zhang, Cheng-Chao Ruan and Wai San Cheang
    Citation: Chinese Medicine 2021 16:69
    Content type: Research Published on:

  50. Nonalcoholic fatty liver disease (NAFLD) has become the world's largest chronic liver disease, while there is still no specific drug to treat NAFLD. Traditional Chinese Medicine (TCM) have been widely used in ...

    Authors: Xianmin Dai, Jiayi Feng, Yi Chen, Si Huang, Xiaofei Shi, Xia Liu and Yang Sun
    Citation: Chinese Medicine 2021 16:68
    Content type: Review Published on:
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