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  1. Bungarus multicinctus, from which a classical Chinese medicine is produced, is known as the most venomous land snake in the world, but the chromatin organization and transcription factor activity during venom rep...

    Authors: Xuejiao Liao, Shuai Guo, Xianmei Yin, Baosheng Liao, Mingqian Li, He Su, Qiushi Li, Jin Pei, Jihai Gao, Juan Lei, Xiwen Li, Zhihai Huang, Jiang Xu and Shilin Chen

    Citation: Chinese Medicine 2021 16:90

    Content type: Research

    Published on:

  2. Fagopyrum dibotrys (F. dibotrys) (D.Don) H.Hara is a well-known edible herbal medicine in Asian countries. It has been widely used for the treatment of lung diseases, swelling, etc., and is also an important par...

    Authors: Le-Le Zhang, Yan He, Feiya Sheng, Ying-Fan Hu, Yu Song, Wei Li, Jiarong Chen, Jinming Zhang and Liang Zou

    Citation: Chinese Medicine 2021 16:89

    Content type: Review

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  3. Amending from ancient classic, Ziyin Tongluo Formula (ZYTLF) has been prescribed to treat postmenopausal osteoporosis (PMOP) for decades with good curative effect. However, the possible mechanisms of it are st...

    Authors: Rong-Bin Chen, Ying-Dong Yang, Kai Sun, Shan Liu, Wei Guo, Jin-Xin Zhang and Yong Li

    Citation: Chinese Medicine 2021 16:88

    Content type: Research

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  4. Microwave technology is used throughout the world to generate heat using energy from the microwave range of the electromagnetic spectrum. It is characterized by uniform energy transfer, low energy consumption,...

    Authors: Qi Hu, Yanan He, Fang Wang, Jing Wu, Zhimin Ci, Lumeng Chen, Runchun Xu, Ming Yang, Junzhi Lin, Li Han and Dingkun Zhang

    Citation: Chinese Medicine 2021 16:87

    Content type: Review

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  5. With the advanced discoveries in the field of pathogenesis, a series of cerebral diseases, such as cerebral ischaemia, Alzheimer's disease, and depression, have been found to have multiple signalling targets i...

    Authors: Wenwen Zhang, Fangling Zhang, Qichao Hu, Xiaolin Xiao, Linbo Ou, Yuan Chen, Shiqing Luo, Yonghong Cheng, Yinxiao Jiang, Xiao Ma and Yanling Zhao

    Citation: Chinese Medicine 2021 16:86

    Content type: Review

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  6. Belamcanda chinensis (L.) DC. (BC) belongs to the family of Iridaceae and is widely cultivated and used in many Chinese patent medicine and Chinese medicinal formulae. However, due to the high similarities in app...

    Authors: Hongxu Zhou, Yi Zhang, Hui Liang, Huijie Song, Jiaming Zhao, Li Liu, Jun Zeng, Lei Sun, Shuangcheng Ma and Dali Meng

    Citation: Chinese Medicine 2021 16:85

    Content type: Research

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  7. Filifolium sibiricum (L.)Kitam (F. sibiricum), a compositae plant, is especially used to inhibit drug-resistant bacteria in folk medicine. Modern pharmacological studies also confirmed a variety of pharmacologica...

    Authors: Shaowa Lv, Qian Qiu, Qiuhong Wang and Haixue Kuang

    Citation: Chinese Medicine 2021 16:83

    Content type: Review

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  8. Post-ischemic inflammation is a crucial component in stroke pathology in the early phase of cerebral ischemia–reperfusion (I/R) injury. Inflammation caused by microglia, astrocytes, and necrotic cells, produce...

    Authors: Chin-Yi Cheng, Su-yin Chiang, Shung-Te Kao and Shang-Chih Huang

    Citation: Chinese Medicine 2021 16:82

    Content type: Research

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  9. Accumulating evidence indicated that necroptosis plays an essential role in the pathogenesis of inflammatory bowel disease (IBD). The O-linked β-N-acetylglucosaminylation (O-GlcNAcylation) of necroptotic signal m...

    Authors: Fan Wu, Qingqing Shao, Zhe Cheng, Xinyu Xiong, Ke Fang, Yan Zhao, Ruolan Dong, Lijun Xu, Fuer Lu and Guang Chen

    Citation: Chinese Medicine 2021 16:78

    Content type: Research

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  10. Chaihu-Shugan-San (CSS, named Shihosogansan in Korean), a Chinese traditional medicine, is frequently used to treat anxiety and depression. Psychiatric disorders including depression are associated with gut dy...

    Authors: Sang-Kap Han, Jeon-Kyung Kim, Hee-Seo Park, Yeun-Jeong Shin and Dong-Hyun Kim

    Citation: Chinese Medicine 2021 16:77

    Content type: Research

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  11. Paclitaxel-induced peripheral neuropathy (PIPN) is a challenging clinical problem during chemotherapy. Our previous work found that herbal formula Huangqi Guizhi Wuwu decoction (HGWD) could reduce oxaliplatin-...

    Authors: Zhangming Lv, Jiayun Shen, Xuejiao Gao, Yonglan Ruan, Jinying Ling, Rongwei Sun, Jingya Dai, Haizhen Fan, Xiaolan Cheng and Peng Cao

    Citation: Chinese Medicine 2021 16:76

    Content type: Research

    Published on:

  12. Ulcerative colitis (UC) is an important inflammatory phenotype in bowel disease (IBD), which is caused by multiple potential factors, including fungal dysbiosis. Candida albicans (C. albicans) was confirmed to be...

    Authors: Zhijun Han, Xiaofen Tan, Juan Sun, Tianming Wang, Guiming Yan, Changzhong Wang and Kelong Ma

    Citation: Chinese Medicine 2021 16:75

    Content type: Research

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  13. With the advances in biomedical technologies, natural products have attracted substantial public attention in the area of drug discovery. Flavonoids are a class of active natural products with a wide range of ...

    Authors: Qichao Hu, Caiyan Qu, Xiaolin Xiao, Wenwen Zhang, Yinxiao Jiang, Zhao Wu, Dan Song, Xi Peng, Xiao Ma and YanLing Zhao

    Citation: Chinese Medicine 2021 16:74

    Content type: Review

    Published on:

  14. The biofilm state of pathogens facilitates antimicrobial resistance which makes difficult-to-treat infections. In this regard, it has been found that the compounds screened from plant extracts represent one ca...

    Authors: Lan Lu, Yuting Zhao, Guojuan Yi, Mingxing Li, Li Liao, Chen Yang, Chihin Cho, Bin Zhang, Jie Zhu, Kun Zou and Qiang Cheng

    Citation: Chinese Medicine 2021 16:72

    Content type: Research

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  15. It is well-known that Prof. Tu Youyou won the Nobel Prize in Physiology or Medicine in 2015 due to the research on artemisinin treating malaria, and this can be regarded as the milestone of modernization of Tr...

    Authors: Hua Luo, Hongguo Chen, Chang Liu, Siyuan Zhang, Chi Teng Vong, Dechao Tan, Yuntao Dai, Yitao Wang and Shilin Chen

    Citation: Chinese Medicine 2021 16:70

    Content type: Review

    Published on:

  16. 3,3′,4,5′-tetramethoxy-trans-stilbene (3,3′,4,5′-TMS) and 3,4′,5-trimethoxy-trans-stilbene (3,4′,5-TMS) are two methoxy derivatives of resveratrol. Previous researches have proved that resveratrol and its analogu...

    Authors: Chunxiu Zhou, Xutao Zhang, Cheng-Chao Ruan and Wai San Cheang

    Citation: Chinese Medicine 2021 16:69

    Content type: Research

    Published on:

  17. Nonalcoholic fatty liver disease (NAFLD) has become the world's largest chronic liver disease, while there is still no specific drug to treat NAFLD. Traditional Chinese Medicine (TCM) have been widely used in ...

    Authors: Xianmin Dai, Jiayi Feng, Yi Chen, Si Huang, Xiaofei Shi, Xia Liu and Yang Sun

    Citation: Chinese Medicine 2021 16:68

    Content type: Review

    Published on:

  18. Exaggerated immune response and cytokine storm are accounted for the severity of COVID-19, including organ dysfunction, especially progressive respiratory failure and generalized coagulopathy. Uncontrolled act...

    Authors: Yadong Fan, Ying Wang, Shuang Yu, Jun Chang, Yiqi Yan, Yiyang Wang and Yuhong Bian

    Citation: Chinese Medicine 2021 16:67

    Content type: Review

    Published on:

  19. Idiopathic pulmonary fibrosis (IPF) is a serious chronic disease of the respiratory system, but its current treatment has certain shortcomings and adverse effects. In this study, we evaluate the antifibrotic a...

    Authors: Yanfang Peng, Yingwen Zhang, Yabing Zhang, Xiuping Wang and Yukun Xia

    Citation: Chinese Medicine 2021 16:66

    Content type: Research

    Published on:

  20. Synaptic damage and glutamate excitotoxicity have been implicated in the pathogenesis of vascular dementia (VD). Clathrin, RAB5B and N-methyl-d-aspartic acid receptor 1 (NMDAR1) proteins play a vital role in endo...

    Authors: Danfeng Tian, Yangyang Guo, Dandan Zhang, Qiang Gao, Ganlu Liu, Jingfeng Lin, Ze Chang, Yuchun Wang, Rui Su and Zhenyun Han

    Citation: Chinese Medicine 2021 16:65

    Content type: Research

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  21. To assess the reporting quality of randomised controlled trials (RCTs) of massage, particularly whether necessary elements related to massage interventions were adequately reported.

    Authors: Xuan Zhang, Lin Zhang, Weifeng Xiong, Xihong Wang, Xiaohan Zhou, Chen Zhao, Guihua Tian, Hongcai Shang, Taixiang Wu, Jiangxia Miao and Zhaoxiang Bian

    Citation: Chinese Medicine 2021 16:64

    Content type: Research

    Published on:

  22. The worldwide prevalence of nonalcoholic fatty liver disease (NAFLD) is increasing, and this metabolic disorder has been recognized as a severe threat to human health. A variety of chemical drugs have been app...

    Authors: Xiao-Fang Yang, Ming Lu, Lijiao You, Huan Gen, Lin Yuan, Tianning Tian, Chun-Yu Li, Kailiang Xu, Jie Hou and Ming Lei

    Citation: Chinese Medicine 2021 16:62

    Content type: Review

    Published on:

  23. Panax notoginseng saponins (PNS) as the main effective substances from P. notoginseng with low bioavailability could be bio-converted by human gut microbiota. In our previous study, PNS metabolic variations media...

    Authors: Li Wang, Man-Yun Chen, Li Shao, Wei Zhang, Xiang-Ping Li and Wei-Hua Huang

    Citation: Chinese Medicine 2021 16:60

    Content type: Research

    Published on:

  24. The traditional Chinese medicine Huangqi decoction (HQD) consists of Radix Astragali and Radix Glycyrrhizae in a ratio of 6: 1, which has been used for the treatment of liver fibrosis. In this study, we tried to ...

    Authors: Biting Wang, Zengrui Wu, Weihua Li, Guixia Liu and Yun Tang

    Citation: Chinese Medicine 2021 16:59

    Content type: Research

    Published on:

  25. Corydalis saxicola Bunting, affiliated with the Papaveraceae Juss., has been proven to work well in anti-inflammation, hemostasis, and analgesia. This study was designed to observe the effect and potential mechan...

    Authors: Chu Xue, Si-Xue Liu, Jie Hu, Jin Huang, Hong-Min Liu, Zhi-Xia Qiu and Fang Huang

    Citation: Chinese Medicine 2021 16:58

    Content type: Research

    Published on:

  26. The desire to extend the wisdom of traditional health systems has motivated the trade of many phytomedicine on a global scale for centuries, especially some dietary herbs, making a great overlap exits between ...

    Authors: Xiuzhu Li, Weijie Chen, Jesus Simal-Gandara, Milen I. Georgiev, Hongyi Li, Hao Hu, Xu Wu, Thomas Efferth and Shengpeng Wang

    Citation: Chinese Medicine 2021 16:57

    Content type: Review

    Published on:

    The Correction to this article has been published in Chinese Medicine 2021 16:79

  27. Acupuncture is used in the treatment of a variety of inflammatory conditions and diseases. However, the mechanisms of its anti-inflammatory action are complex and have not been systematically investigated. Mac...

    Authors: Jiaqi Wang, Shanshan Lu, Fuming Yang, Yi Guo, Zelin Chen, Nannan Yu, Lin Yao, Jin Huang, Wen Fan, Zhifang Xu and Yinan Gong

    Citation: Chinese Medicine 2021 16:56

    Content type: Review

    Published on:

  28. The pathological process of myocardial ischemia (MI) is very complicated. Acupuncture at PC6 has been proved to be effective against MI injury, but the mechanism remains unclear. This study investigated the me...

    Authors: Jing Yuan, Jun-Meng Wang, Zhi-Wei Li, Cheng-Shun Zhang, Bin Cheng, Su-Hao Yang, Bai-Tong Liu, Li-Juan Zhu, Ding-Jun Cai and Shu-Guang Yu

    Citation: Chinese Medicine 2021 16:55

    Content type: Research

    Published on:

  29. Hypertension (HTN) patients who have phlegm-dampness syndrome (PDS) tend to be obese and have worse outcomes. However, the association of body weight (BW) changes and mechanisms underlying the pathophysiology ...

    Authors: Chi Zhang, Li Li, Shiping Cheng, Debajyoti Chowdhury, Yong Tan, Xinru Liu, Ning Zhao, Xiaojuan He, Miao Jiang, Cheng Lu and Aiping Lyu

    Citation: Chinese Medicine 2021 16:54

    Content type: Research

    Published on:

  30. Although molecular analysis offers a wide range of options for species identification, a universal methodology for classifying and distinguishing closely related species remains elusive. This study validated t...

    Authors: Lan Wu, Mingli Wu, Ning Cui, Li Xiang, Ying Li, Xiwen Li and Shilin Chen

    Citation: Chinese Medicine 2021 16:52

    Content type: Research

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  31. The raw and processed roots of Polygonum multiflorum Thunb (PM) are commonly used in clinical practice to treat diverse diseases; however, reports of hepatotoxicity induced by Polygoni Multiflori Radix (PMR) and ...

    Authors: Jian-Bo Yang, Yun-Fei Song, Yue Liu, Hui-Yu Gao, Qi Wang, Ying Wang, Xian-Long Cheng, Tian-Tian Zuo, Xiao-Wen Hu, Feng Wei, Hong-Tao Jin, Shu-Ting Wang and Shuang-Cheng Ma

    Citation: Chinese Medicine 2021 16:51

    Content type: Research

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  32. It is essential to identify the chemical components for the quality control methods establishment of Chinese Classical Formula (CCF). However, CCF are complex mixture of several herbal medicines with huge numb...

    Authors: Xiaoxia Xue, Qishu Jiao, Runa Jin, Xueyuan Wang, Pengyue Li, Shougang Shi, Zhengjun Huang, Yuntao Dai and Shilin Chen

    Citation: Chinese Medicine 2021 16:50

    Content type: Research

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  33. Honeysuckle is a time‐honored herb with anticancer activity in traditional Chinese medicine. Recently, accumulating reports are suggesting that the microRNAs in this medicinal plant not only play a physiologic...

    Authors: Chunyan Liu, Mengzhen Xu, Luocheng Yan, Yulian Wang, Zhen Zhou, Shaocong Wang, Yajie Sun, Junfeng Zhang and Lei Dong

    Citation: Chinese Medicine 2021 16:49

    Content type: Research

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  34. Tanshinone I (TI) is a primary component of Salvia miltiorrhiza Bunge (Danshen), which confers a favorable role in a variety of pharmacological activities including cardiovascular protection. However, the exact m...

    Authors: Youqiong Zhuo, Renyikun Yuan, Xinxin Chen, Jia He, Yangling Chen, Chenwei Zhang, Kaili Sun, Shilin Yang, Zhenjie Liu and Hongwei Gao

    Citation: Chinese Medicine 2021 16:48

    Content type: Research

    Published on:

  35. Alzheimer’s disease (AD) is a progressive neurodegenerative disease characterized by memory deficits and cognitive decline. Current drugs can only relieve symptoms, but cannot really cure AD. Cerebralcare Gran...

    Authors: Ou Qiao, Xinyu Zhang, Yi Zhang, Haixia Ji, Zhi Li, Xiaoying Han, Wenzhe Wang, Xia Li, Juan Wang, Changxiao Liu and Wenyuan Gao

    Citation: Chinese Medicine 2021 16:47

    Content type: Research

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  36. Musk, the dried secretion from the musk sac gland which is located between the navel and genitals of mature male musk deer, is utilized as oriental medicine in east Asia. It has been utilized to treat conditio...

    Authors: Kai Liu, Long Xie, Mao Deng, Xumin Zhang, Jia Luo and Xiaofang Li

    Citation: Chinese Medicine 2021 16:46

    Content type: Review

    Published on:

  37. Panax notoginseng (Burk.) F. H. Chen (P. notoginseng) is a traditional Chinese medicine that has been used therapeutically for cardiovascular diseases, inflammatory diseases and traumatic injuries as well as for ...

    Authors: Li Zhang, Qin Hu, Haonan Jin, Yongzhao Yang, Yan Yang, Renhua Yang, Zhiqiang Shen and Peng Chen

    Citation: Chinese Medicine 2021 16:45

    Content type: Research

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  38. The coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), first broke out in Wuhan, China, in 2019. SARS-CoV-2 develops many types of mutations (such as B...

    Authors: Xuedong An, Liyun Duan, Yue Hong Zhang, De Jin, Shenghui Zhao, Rong Rong Zhou, Yingying Duan, Fengmei Lian and Xiaolin Tong

    Citation: Chinese Medicine 2021 16:44

    Content type: Review

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  39. Inflammatory bowel diseases (IBD) are chronic relapsing intestinal inflammations with increasing global incidence, and new drug development remains in urgent demand for IBD management. To identify effective tr...

    Authors: Yunru Yu, Jing Chen, Xiaohui Zhang, Yingchao Wang, Shufang Wang, Lu Zhao and Yi Wang

    Citation: Chinese Medicine 2021 16:42

    Content type: Research

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  40. Polyphyllin VII (PP7), a steroidal saponin from P. polyphylla has been found to exert strong anticancer activity. Little is known about the anti-angiogenesis and anti-metastasis properties of PP7. In this study, ...

    Authors: Chao Zhang, Qingrui Li, Guozheng Qin, Yi Zhang, Chaoying Li, Liwen Han, Rongchun Wang, Shudan Wang, Haixia Chen, Kechun Liu and Chengwei He

    Citation: Chinese Medicine 2021 16:41

    Content type: Research

    Published on: