Articles

Effects of different principles of Traditional Chinese Medicine treatment on TLR7/NF-κB signaling pathway in influenza virus infected mice

Influenza virus is a single-stranded RNA virus that causes influenza in humans and animals. About 600 million people around the world suffer from influenza every year. Upon recognizing viral RNA molecules, TLR...

Authors: Ying-Jie Fu, Yu-Qi Yan, Hong-Qiong Qin, Sha Wu, Shan-Shan Shi, Xiao Zheng, Peng-Cheng Wang, Xiao-Yin Chen, Xiao-Long Tang and Zhen-You Jiang

Diversity and composition of bacterial endophytes among plant parts of Panax notoginseng

Bacterial endophytes are widespread inhabitants inside plant tissues that play crucial roles in plant growth and biotransformation. This study aimed to offer information for the exploitation of endophytes by a...

Authors: Linlin Dong, Ruiyang Cheng, Lina Xiao, Fugang Wei, Guangfei Wei, Jiang Xu, Yong Wang, Xiaotong Guo, Zhongjian Chen and Shilin Chen

Bioaccessibility and risk assessment of heavy metals, and analysis of arsenic speciation in Cordyceps sinensis

Cordyceps sinensis (C. sinensis) is a famous and precious Traditional Chinese Medicine (TCM), while frequent reports of heavy metals, especially arsenic, exceeding standards in C. sinensis in recent years have ra...

Authors: Li Zhou, Sheng Wang, Qingxiu Hao, Liping Kang, Chuanzhi Kang, Jian Yang, Wanzhen Yang, Jingyi Jiang, Lu-Qi Huang and Lanping Guo

Triphala: current applications and new perspectives on the treatment of functional gastrointestinal disorders

Ayurvedic medicine is based on natural healing methods that use herbal medicine to cleanse the body of toxins and to attain physical and mental regeneration. Triphala (TLP) is one of the most important ayurved...

Authors: Aleksandra Tarasiuk, Paula Mosińska and Jakub Fichna

Effect of Da-Cheng-Qi decoction for treatment of acute kidney injury in rats with severe acute pancreatitis

The traditional Chinese formula Da-Cheng-Qi-decoction (DCQD) has been used to treat acute pancreatitis for decades. DCQD could ameliorate the disease severity and the complications of organ injuries, including...

Authors: Ling Yuan, Lv Zhu, Yumei Zhang, Huan Chen, Hongxin Kang, Juan Li, Xianlin Zhao, Meihua Wan, Yifan Miao and Wenfu Tang

Siegesbeckia pubescens Makino inhibits Pam₃CSK₄-induced inflammation in RAW 264.7 macrophages through suppressing TLR1/TLR2-mediated NF-κB activation

Siegesbeckia pubescens Makino (SP) is one of the important plant origins for the anti-inflammatory Chinese herbal medicine of Siegesbeckiae Herba. The current investigations indicated that the anti-inflammatory e...

Authors: Wei Sang, Zhangfeng Zhong, Kegang Linghu, Wei Xiong, Anfernee Kai Wing Tse, Wai San Cheang, Hua Yu and Yitao Wang

Combination of Salvia miltiorrhiza and ligustrazine attenuates bleomycin-induced pulmonary fibrosis in rats via modulating TNF-α and TGF-β

Idiopathic pulmonary fibrosis (IPF), a chronic, progressive, fibrosing interstitial lung disease, is associated with extremely poor prognosis, and lacks effective treatment. The frequently used immunosuppressi...

Authors: Chengliang Huang, Xu Wu, Shengpeng Wang, Wenjun Wang, Fang Guo, Yuanyuan Chen, Bi Pan, Ming Zhang and Xianming Fan

Anticancer drug discovery from Chinese medicinal herbs

Cancer is still presenting a serious threat to human health worldwide. The understanding of the complex biology of cancer and the development of oncotherapy have led to increasing treatment approaches such as ...

Authors: Mu-Yang Huang, Le-Le Zhang, Jian Ding and Jin-Jian Lu

Corni Fructus: a review of chemical constituents and pharmacological activities

Cornus officinalis Sieb. et Zucc. is part of the genus Cornus of the family Cornaceae. Ripening and dry fruits (Corni Fructus) are recognized as an essential herb medicine in the traditional Chinese medicine (TCM...

Authors: Yu Dong, Zhe-Ling Feng, Hu-Biao Chen, Fu-Sheng Wang and Jia-Hong Lu

In silico approach in reveal traditional medicine plants pharmacological material basis

In recent years, studies of traditional medicinal plants have gradually increased worldwide because the natural sources and variety of such plants allow them to complement modern pharmacological approaches. As...

Authors: Fan Yi, Li Li, Li-jia Xu, Hong Meng, Yin-mao Dong, Hai-bo Liu and Pei-gen Xiao

Effective authentication of Placenta Hominis

Human placenta is used to make the medicinal product Placenta Hominis in Asian countries. With its therapeutic benefits and limited supply, intentional or inadvertent adulteration is found in the market. In or...

Authors: Yat-Tung Lo, Mavis Hong-Yu Yik and Pang-Chui Shaw

Global ecological regionalization of 15 Illicium species: nature sources of shikimic acid

Illicium plants are relevant officinal and ornamental species that are native in Eastern Asia, and they are the main sources of shikimic acid. Shikimic acid is an important component of Tamiflu, which is recogniz...

Authors: Xiang Zhang, Xiangxiao Meng, Jie Wu, Linfang Huang and Shilin Chen

The therapeutic effect of scalp acupuncture on natal autism and regressive autism

Autism spectrum disorders (ASD) is a common disease and the incidence has been rising constantly. Acupuncture is one of the most widely used complementary and alternative medicine therapies. Despite studies ha...

Authors: Chuen Heung Yau, Cheuk Long Ip and Yuk Yin Chau

Isorhynchophylline alleviates learning and memory impairments induced by aluminum chloride in mice

To evaluate the effect of Isorhynchophylline (IRN) on the learning and memory impairments induced by aluminum chloride (AlCl₃) in mice.

Authors: Hui-Qin Li, Siu-Po Ip, Guo-Qing Zheng, Yan-Fang Xian and Zhi-Xiu Lin

Cost-consequence analysis of salvianolate injection for the treatment of coronary heart disease

Complicated with the impact of aging population and urbanization, coronary heart disease (CHD) incurs more and more disease burdens in China. Salvianolate injection is a Chinese patent drug widely used for tre...

Authors: Pengxin Dong, Hao Hu, Xiaodong Guan, Carolina Oi Lam Ung, Luwen Shi, Sheng Han and Shuwen Yu

Cellular stress response mechanisms of Rhizoma coptidis: a systematic review

Rhizoma coptidis has been used in China for thousands of years with the functions of heating dampness and purging fire detoxification. But the underlying molecular mechanisms of Rhizoma coptidis are still far ...

Authors: Jin Wang, Qian Ran, Hai-rong Zeng, Lin Wang, Chang-jiang Hu and Qin-wan Huang

Abstracts from the 2nd International Symposium on Phytochemicals in Medicine and Food (2-ISPMF)

Authors:

Clarifying the origin of Houzao

Houzao (bezoar) is a valuable imported Chinese medicine that is commonly used as a pediatric medicine to transform phlegm. There are mainly two types of Houzao, “Southeast Asian Houzao” and “Indian Houzao”. “I...

Authors: Zhongzhen Zhao, Eric Brand, Hiu Yee Kwan, Quanbin Han and Mengjia Zhou

Pharmacokinetics of Chinese medicines: strategies and perspectives

The modernization and internationalization of Chinese medicines (CMs) are hampered by increasing concerns on the safety and the efficacy. Pharmacokinetic (PK) study is indispensable to establish concentration-...

Authors: Ru Yan, Ying Yang and Yijia Chen

Extrahepatic cytochrome P450s play an insignificant role in triptolide-induced toxicity

Triptolide, an active ingredient of Chinese medicine plant Tripterygium wilfordii Hook.f., has been shown to exert anti-tumor, immunosuppressive, anti-inflammatory, and anti-fertility pharmacological effects. How...

Authors: Yuan Wei, Dujun Wang, Meng Chen, Zhen Ouyang, Shuo Wang and Jun Gu

Comparative study of the polyphenol content-related anti-inflammatory and antioxidant activities of two Urera aurantiaca specimens from different geographical areas

Urera aurantiaca is an Argentinean species that has been traditionally used to treat symptoms of inflammation. The aim of this study was to determine and compare the anti-inflammatory and antioxidant effects of t...

Authors: Carla Marrassini, Ignacio Peralta and Claudia Anesini

Wentong decoction cures allergic bronchial asthma by regulating the apoptosis imbalance of EOS

Eosinophils (EOS) is one of the most important cells involved in the pathogenesis of chronic airway inflammation in asthma, and its apoptosis is part of the mechanisms of asthma. Therefore, this study aimed to...

Authors: Yue Yan, Hai-Peng Bao, Chun-Lei Li, Qi Shi, Yan-Hua Kong, Ting Yao and You-Lin Li

Techniques for extraction and isolation of natural products: a comprehensive review

Natural medicines were the only option for the prevention and treatment of human diseases for thousands of years. Natural products are important sources for drug development. The amounts of bioactive natural p...

Authors: Qing-Wen Zhang, Li-Gen Lin and Wen-Cai Ye

HPLC–ICP-MS speciation analysis and risk assessment of arsenic in Cordyceps sinensis

Cordyceps sinensis, one of the most valued traditional herbal medicines in China, contains high amount of arsenic. Considering the adverse health effects of arsenic, this is of particular concern. The aim of this...

Authors: Tian-Tian Zuo, Yao-Lei Li, Hong-Yu Jin, Fei Gao, Qi Wang, Ya-Dan Wang and Shuang-Cheng Ma

A concise classification of bencao (materia medica)

Books that record the sources and applications of medicinal materials are commonly known as bencao (materia medica) in China. Bencao (materia medica) literature review is the very first step in the standard authe...

Authors: Zhongzhen Zhao, Ping Guo and Eric Brand

Wenyang Huazhuo Tongluo formula inhibits fibrosis via suppressing Wnt/β-catenin signaling pathway in a Bleomycin-induced systemic sclerosis mouse model

Systemic sclerosis (SSc) is an autoimmune disease characterized by fibrosis of the skin and internal organs. So far, no Western medicine treatment can completely inhibit or reverse the progress of SSc, while a...

Authors: Qian Wang, Wenhua Zang, Li Han, Lei Yang, Songshan Ye, Jingfeng Ouyang, Chaoyun Zhang, Yuefeng Bi, Cuiyue Zhang and Hua Bian

Psoriasis therapy by Chinese medicine and modern agents

Psoriasis is a chronic, painful, disfiguring and non-contagious skin disease that has globally affected at least 200 million patients. In general, mild to moderate psoriasis patients will be treated by chemica...

Authors: Shikang Meng, Zibei Lin, Yan Wang, Zhenping Wang, Ping Li and Ying Zheng

Approaches in studying the pharmacology of Chinese Medicine formulas: bottom-up, top-down—and meeting in the middle

Investigating the pharmacology is key to the modernization of Chinese Medicine (CM) formulas. However, identifying which are the active compound(s) of CM formulas, which biological entities they target, and th...

Authors: Tao Huang, Linda L. D. Zhong, Chen-Yuan Lin, Ling Zhao, Zi-Wan Ning, Dong-Dong Hu, Man Zhang, Ke Tian, Chung-Wah Cheng and Zhao-Xiang Bian

Paeoniflorin exerts neuroprotective effects by modulating the M1/M2 subset polarization of microglia/macrophages in the hippocampal CA1 region of vascular dementia rats via cannabinoid receptor 2

Cerebral hypoperfusion is a pivotal risk factor for vascular dementia (VD), for which effective therapy remains inadequate. Persistent inflammatory responses and excessive chemotaxis of microglia/macrophages i...

Authors: Xian-Qin Luo, Ao Li, Xue Yang, Xiao Xiao, Rong Hu, Tian-Wen Wang, Xiao-Yun Dou, Da-Jian Yang and Zhi Dong

Coptidis rhizoma and its main bioactive components: recent advances in chemical investigation, quality evaluation and pharmacological activity

Coptidis rhizoma (CR) is the dried rhizome of Coptis chinensis Franch., C. deltoidea C. Y. Cheng et Hsiao or C. teeta Wall. (Ranunculaceae) and is commonly used in Traditional Chinese Medicine for the treatment o...

Authors: Fan-Cheng Meng, Zheng-Feng Wu, Zhi-Qi Yin, Li-Gen Lin, Ruibing Wang and Qing-Wen Zhang

Development of models for classification of action between heat-clearing herbs and blood-activating stasis-resolving herbs based on theory of traditional Chinese medicine

Action (“gongxiao” in Chinese) of traditional Chinese medicine (TCM) is the high recapitulation for therapeutic and health-preserving effects under the guidance of TCM theory. TCM-defined herbal properties (“yaox...

Authors: Zhao Chen, Yanfeng Cao, Shuaibing He and Yanjiang Qiao

Ginsenoside G-Rh2 synergizes with SMI-4a in anti-melanoma activity through autophagic cell death

Melanoma is a leading cause of cancer death worldwide, and SMI-4a and G-Rh2 exert anti-tumor activity in multiple cancer. However, SMI-4a as well as a synergistic relationship between SMI-4a and G-Rh2 in anti-...

Authors: Da-lun Lv, Lei Chen, Wei Ding, Wei Zhang, He–li Wang, Shuai Wang and Wen-bei Liu

Complete chloroplast genome of the medicinal plant Amomum compactum: gene organization, comparative analysis, and phylogenetic relationships within Zingiberales

Amomum compactum is one of the basic species of the traditional herbal medicine amomi fructus rotundus, with great pharmacology effect. The system position of A. compactum is not clear yet, and the introduction o...

Authors: Ming-li Wu, Qing Li, Jiang Xu and Xi-wen Li

Internationalization of traditional Chinese medicine: current international market, internationalization challenges and prospective suggestions

Through reviewing the current international market for traditional Chinese medicine (TCM), this paper identified the internationalization challenges for TCM, including unclear therapeutic material basis and me...

Authors: Annie Xianghong Lin, Ging Chan, Yuanjia Hu, Defang Ouyang, Carolina Oi Lam Ung, Luwen Shi and Hao Hu

Authenticity analyses of Rhizoma Paridis using barcoding coupled with high resolution melting (Bar-HRM) analysis to control its quality for medicinal plant product

Rhizoma Paridis (Chonglou) is a commonly used and precious traditional Chinese medicine. Paris polyphylla Smith var. yunnanensis (Franch.) Hand. -Mazz. and Paris polyphylla Smith var. chinensis (Franch.) Hara are...

Authors: Bao-Zhong Duan, Ya-Ping Wang, Hai-Lan Fang, Chao Xiong, Xi-Wen Li, Ping Wang and Shi-Lin Chen

Bioactive polysaccharides from natural resources including Chinese medicinal herbs on tissue repair

Functional polysaccharides can be derived from plants (including herbs), animals and microorganisms. They have been widely used in a broad of biomedical applications, such as immunoregulatory agents or drug de...

Authors: Qiu Li, Yiming Niu, Panfei Xing and Chunming Wang

Shuganyin decoction improves the intestinal barrier function in a rat model of irritable bowel syndrome induced by water-avoidance stress

To determine the effect of Shuganyin decoction (SGD) on the intestinal barrier function in an irritable bowel syndrome (IBS) rat model induced by water-avoidance stress.

Authors: Lu Lu, Liang Yan, Jianye Yuan, Qing Ye and Jiang Lin

SWOT analysis and revelation in traditional Chinese medicine internationalization

Traditional Chinese medicine (TCM) is currently the best-preserved and most influential traditional medical system with the largest number of users worldwide. In recent years, the trend of TCM adoption has inc...

Authors: Haitao Tang, Wenlong Huang, Jimei Ma and Li Liu

Seeing the unseen of Chinese herbal medicine processing (Paozhi): advances in new perspectives

Processing (Paozhi) represents a unique Chinese pharmaceutic technique to facilitate the use of Chinese herbal medicines (CHMs) for a specific clinical need in the guidance of Traditional Chinese Medicine (TCM) t...

Authors: Xu Wu, Shengpeng Wang, Junrong Lu, Yong Jing, Mingxing Li, Jiliang Cao, Baolin Bian and Changjiang Hu

Effects of Huang Bai (Phellodendri Cortex) on bone growth and pubertal development in adolescent female rats

To evaluate the effects of Huang Bai (Phellodendron amurense) on growth and maturation in adolescent female rats.

Authors: Sun Haeng Lee, Hyun Jeong Lee, Sung Hyun Lee, Young-Sik Kim, Donghun Lee, Jiu Chun, Jin Yong Lee, Hocheol Kim and Gyu Tae Chang

iTRAQ-based proteomic analysis to identify the molecular mechanism of Zhibai Dihuang Granule in the Yin-deficiency-heat syndrome rats

Zhibai Dihuang Granule (ZDG) is a traditional Chinese medicine which has been used to treat Yin-deficiency-heat (YDH) syndrome for thousands of years in China. However, little work has been conducted to explor...

Authors: Chang-Ming Liu, Jing Chen, Su Yang, Ting-Ting Jiang, Zhong-Liang Chen, Hui-Hui Tu, Lian-Gen Mao, Yu-Ting Hu, Lin Gan, Zhong-Jie Li and Ji-Cheng Li

Different modulation of Panax notoginseng on the absorption profiling of triptolide and tripterine from Tripterygium wilfordii in rat intestine

Compatibility with Panax notoginseng (PN) reduced the plasma concentration of triptolide and delayed the T_max of Tripterygium wilfordii (TW), the sovereign medicine of Qing-Luo Tong-Bi decoction, which hinted the...

Authors: Yiqun Li, Huiting Cao, Mengzhu Liu, Benyong Zhang, Xinlong Zhang, Donglei Shi, Liwei Guo, Jinao Duan, Xueping Zhou, Huaxu Zhu and Qichun Zhang

Advances in bio-active constituents, pharmacology and clinical applications of rhubarb

Rhubarb is one of the most ancient, commonly used and important herbs in Chinese medicine. The modern researches of rhubarb clarified the efficacies, ingredients and mechanisms in a more scientific and rigorou...

Authors: Yu-Jie Cao, Zong-Jin Pu, Yu-Ping Tang, Juan Shen, Yan-Yan Chen, An Kang, Gui-Sheng Zhou and Jin-Ao Duan

Metabolic regulations of a decoction of Hedyotis diffusa in acute liver injury of mouse models

Dysfunctional metabolisms are contributed to LPS/GALN-induced hepatitis. However, whether Hedyotis diffusa (HD) employs metabolic strategies against hepatitis is unknown.

Authors: Min Dai, Fenglin Wang, Zengcheng Zou, Gemin Xiao, Hongjie Chen and Hongzhi Yang

Discrimination of Radix Polygoni Multiflori from different geographical areas by UPLC-QTOF/MS combined with chemometrics

Nowadays, Radix Polygoni Multiflori (RPM, Heshouwu in Chinese) from different geographical origins were used in clinic. In order to characterize the chemical profiles of different geographical origins of RPM s...

Authors: Jin-Fa Tang, Wei-Xia Li, Fan Zhang, Yu-Hui Li, Ying-Jie Cao, Ya Zhao, Xue-Lin Li and Zhi-Jie Ma

Active fraction (HS7) from Taiwanofungus camphoratus inhibits AKT-mTOR, ERK and STAT3 pathways and induces CDK inhibitors in CL1-0 human lung cancer cells

The non-small cell lung cancer (NSCLC) is the leading cause of cancer death worldwide. In NSCLC, the oncogenic AKT-mTOR, ERK and STAT3 pathways are commonly dysregulated and have emerged as attractive targets ...

Authors: I-Chun Lai, Gi-Ming Lai, Jyh-Ming Chow, Hsin-Lun Lee, Chuan-Feng Yeh, Chi-Han Li, Jiann-Long Yan, Shuang-En Chuang, Jacqueline Whang-Peng, Kuan-Jen Bai and Chih-Jung Yao

Hepatoprotective properties of Penthorum chinense Pursh against carbon tetrachloride-induced acute liver injury in mice

Penthorum chinense Pursh (Penthoraceae, PCP), a well-known Miao ethnomedicine, has been traditionally used to treat several liver-related diseases, such as jaundice and viral hepatitis...

Authors: Meng Wang, Xiao-Jiao Zhang, Ruibing Feng, Yun Jiang, Da-Yong Zhang, Chengwei He, Peng Li and Jian-Bo Wan

Chemical characterization of wound ointment (WO) and its effects on fracture repair: a rabbit model

Wound ointment (WO), a kind of Chinese medicine, can significantly promote fracture healing. The study aimed at analyzing the chemical composition and the effects of WO on fracture of rabbits and tried to expl...

Authors: Zhixue Ou, Qi Cheng, Yueping Chen, Tao Chen, Xiangbin Rong, Feipan Long, Xiaoyun Zhang, Qinghua Liang and Zhe Feng

Effects of pretreatment with methanol extract of Peucedani Radix on transient ischemic brain injury in mice

Stroke is the second most common cause of death and may result in various disabilities; thus, identification of neuroprotective therapeutic agents is important. Peucedani Radix (PR), the root of Angelica decursiv...

Authors: So-Youn Jung, Kyoung-Min Kim, Suin Cho, Sehyun Lim, Chiyeon Lim and Young Kyun Kim

Effect of methanol extract of Salviae miltiorrhizae Radix in high-fat diet-induced hyperlipidemic mice

The dried root of Salvia miltiorrhiza, Salviae miltiorrhizae Radix (SR), is one of the most popular medicinal herbs in Asian countries such as China and Korea. In Asian traditional medicine, SR is considered to h...

Authors: Chiyeon Lim, Sehyun Lim, Byoungho Lee, Buyeo Kim and Suin Cho