Simultaneous determination of three major bioactive saponins of Panax notoginseng using liquid chromatography-tandem mass spectrometry and a pharmacokinetic study

Table 3 Recovery of the three Panax notoginseng saponins from beagle dog plasma (n = 4)

Analyte	Spiked conc. (ng/mL)	Recovery (%)^{a, b}	RSD (%)^c
Notoginsenoside R₁	2.8	96.0 ± 6.72	6.99
	14	104.0 ± 7.71	7.41
	140	102.3 ± 7.82	7.82
Ginsenoside Rg₁	3.8	99.9 ± 6.89	6.90
	19	102.4 ± 6.73	6.57
	190	98.96 ± 8.06	8.14
Ginsenoside Rb₁	18	102.6 ± 9.85	9.60
	180	101.1 ± 10.26	9.14
	900	105.0 ± 8.32	7.92

Note: ^aRecovery (%) = [1 -- (spiked concentration -- measured concentration)/spiked concentration] × 100; ^bValues are the mean ± SD (n = 4); ^c Relative standard deviation

ISSN: 1749-8546