From: Isolation and identification of bioactive compounds in Andrographis paniculata (Chuanxinlian)
Chemicals | Pharmacological properties | References |
---|---|---|
methanol extract | restore plasma lipid peroxidation, ALT, AST activities in CCl4-treated rats (orally 1 g/kg BW, 14d) | [94] |
ethanol extract |   serum anti-Salmonella typhinurium IgG levels   IFN-γ in Con A-stimulated splenocytes of mice (orally, 25 or 50 mg/kg BW, 14d) | [76] |
  antibody and the delayed-type hypersensitivity response (orally 25 mg/kg, 7d) | [74] | |
  G0/G1 phase   mitochondrial CYP and expression of Bax in human leukemic HL-60 cells | [49] | |
  expression of EBV lytic proteins during the viral lytic cycle in P3HR1 cells | [82] | |
  fasting serum glucose in diabetic rats (orally 0.1, 0.2, and 0.4 g/BW, 14d)   liver and kidney TBARS levels   liver GSH concentrations (orally 400 mg/kg BW, 14d) | [113] | |
95% ethanol extract |   RANTES secretion by human bronchial epithelial cells infected with influenza A virus H1N1 | [86] |
80% ethanol extract |   hepatic GPX, GR, CAT, SOD;   lipid peroxidation (orally 50, 100 mg/kg BW, 14d) | [121] |
70% ethanol extract |   CTL production through enhanced secretion of IL-2 and IFNγ by EL-4 T cells | [43] |
 |   serum NO, VEGF and TIMP-1, angiogenesis in melanoma cell implanted mice (i.p. 10 mg/d, 5d) | [56] |
95% ethanol or EtOAc extract |   pi class of glutathione S-transferase expression in rat primary hepatocytes | [99] |
EtOAc extract |   NF-κB trans-activation assayed by NF-κB-dependent luciferase activity   ex-vivo NO and PGE2 production by LPS/IFN-γ-stimulated peritoneal macrophages   LPS-induced acute inflammation in mice (orally 0.78~3.12 mg/kg BW, 7d) | |
aqueous extract |   protect nicotine-induced toxicity in brain (i.p. 250 mg/kg BW, 7d)   nicotine induced DNA fragmentation in lymphocytes, lipid peroxidation, protein oxidation | |
  systolic blood pressure of SHR and WKY rats (i.p. 0.7, 1.4, 2.8 g/kg BW) | [101] | |
  blood glucose in STZ-induced hyperglycaemic rats (50 mg/kg BW, 10d) | [115] | |
  hepatic CAT, SOD and GST activities in lymphoma bearing mice (orally 10~30 mg/d) | [123] |